27 November 2018

In European Journal of Preventive Cardiology Regina Konst and colleagues demonstrated that symptomatic women without obstructive coronary artery disease have a different pattern of risk factors and lower levels of psychosocial well-being compared with those with stable obstructive coronary artery disease.

Background:
characterising patients with symptoms/signs of ischemic heart disease in the absence of obstructed coronary arteries (INOCA) remains challenging. Little is known about differences in risk factors and psychosocial well-being of these patients compared to those with stable angina due to obstructive coronary artery disease (CAD). Therefore, we evaluated patient characteristics in women with INOCA and women with CAD.
 
Methods:
64 symptomatic women aged 40-65 years with INOCA and 64 age-matched symptomatic women with CAD completed questionnaires about traditional cardiovascular risk factors, non-traditional risk variables and psychosocial factors such as fatigue, cardiac anxiety, quality of life and anxiety/depression.
 
Results: no significant differences were found regarding most traditional cardiovascular risk factors. Of the non-traditional risk variables, women with INOCA more often had a history of rheumatic disorders (39% vs. 21%; p < 0,01) and premenopausal migraine (52% vs. 31%; p = 0,02) compared to women with CAD. Women with INOCA reported higher levels of fatigue (89,7 ± 25,3 vs. 76,4 ± 26,9, p < 0,01) and cardiac anxiety (1,5 ± 0,5 vs. 1,3 ± 0,5, p < 0,05) and lower levels of physical quality of life (34,3 ± 10,3 vs. 41,4 ± 10,2, p < 0,01) compared to women with CAD, all related to a higher symptom burden. Levels of anxiety and depression were overall low in both groups without significant differences.
 
Conclusion:
women with INOCA have a different pattern of risk factors and experience more psychosocial distress – related to a higher symptom burden – compared to women with stable obstructive CAD.

Different cardiovascular risk factors and psychosocial burden in symptomatic women with and without obstructive coronary artery disease.
Konst RE, Elias-Smale SE, Lier A, Bode C, Maas AH.

Regina Konst is member of theme Vascular damage. 

 

Related news items


Prinses Beatrix Spierfonds grant to investigate patient stratification in myotonic dystrophy

24 January 2020

Rick Wansink and Roland Brock, both theme Nanomedicine, received a € 280,000 grant from the Prinses Beatrix Spierfonds.

read more

RIMLS PhD retreat registration is open

23 January 2020

Yearly, RIMLS PhD candidates gather for the two-day PhD Retreat. Apart from the science, this event is highly valued for the opportunity to meet and get to know fellow PhD candidates during the social activities. Early bird registration and abstract submission deadline: 4 March 2020.

read more

Cognitive behavioral therapy reduces severe fatigue in patients with advanced cancer during treatment

23 January 2020

In Annals of Oncology, RIHS researchers Hanneke Poort, Marlies Peters, Winette van der Graaf, Ria Nijhuis van der Sanden and colleagues showed significant effects of cognitive behavioral therapy on fatigue in patients with advanced cancer during treatment with palliative intent.

read more

6 million euros to uncover link between metabolic and brain disorders

21 January 2020

An important European-funded initiative, coordinated by Radboudumc researchers Barbara Franke, Jan Buitelaar, and Janita Bralten, has been launched to explore how common molecular mechanisms may link metabolic disorders with brain disorders.

read more

NWO Open Competition Domain Science - XS grant for Ronald van Rij and Jenny van der Wijst

21 January 2020

NWO Domain Science has awarded Ronald van Rij, theme Infectious diseases and global health and Jennny van der Wijst, theme Renal disorders an XS grant. The XS category emphatically strives to encourage curiosity-driven and bold research involving a relatively quick analysis of a promising idea.

read more

First BeNeFit funding granted for psoriasis

17 January 2020

RIHS researchers Elke de Jong and Juul van den Reek of Dermatology Radboudumc and Dermatology Ghent received a grant of 1.6 million euros for investigating dose reduction of the newest biologics for psoriasis.

read more