Vascular damage About theme

New insights into the pathogenesis of atherosclerosis, particularly the role of inflammation, are providing potential new targets for therapy. In addition, preclinical research into the pathophysiology of ischemiareperfusion injury has also provided important new insights.

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Vascular damage About theme

Despite major advances in acute management of ischemic events and treatment of atherosclerosis, cardiovascular disease is still the most important cause of morbidity and mortality worldwide. It is a major challenge to reverse the chronic process and to prevent acute events resulting from plaque rupture and atherothrombosis. New insights into the pathogenesis of atherosclerosis, particularly the role of inflammation, are providing potential new targets for therapy. In addition, organ damage resulting from ischemic events needs to be minimized. Preclinical research into the pathophysiology of ischemiareperfusion injury has also provided important new insights.
 
Translation of these preclinical concepts into clinical realities is a major challenge for this theme, which has a strong track record in human in vivo translational research. In this effort, the impact of inflammation on atherosclerosis and plaque rupture will be an important focus in the years to come. Improving the implementation of evidence-based cardiovascular guidelines so as to prevent and treat cardiovascular disease is another major challenge.

Objectives

  • We aim to unravel how traditional and novel cardiovascular risk factors induce a pro-atherogenic phenotype of these cells by performing in vitro and ex vivo studies on cells of the innate immune system.
  • We plan to develop and improve noninvasive vascular imaging techniques to detect vulnerable plaques and vascular inflammation.
  • We aim to develop and implement techniques to study inflammation and its impact on atherosclerosis in humans in vivo.
  • Using animal models, we aim to develop and validate biomarkers to study the impact of inflammation on progression of atherosclerosis in humans in vivo.
  • We aim to investigate the role of inflammation in the pathogenesis of the metabolic syndrome.
  • We plan to study the mechanisms by which inactivity results in cardiovascular injury and evaluate interventions to prevent or reverse this.
  • We want to improve diagnosis and treatment of the adrenal causes of hypertension and to explore mechanisms of vascular injury specifically related to these disorders.
  • We aim to explore the role of gender differences in atherogenesis.
  • We will study promising strategies to prevent ischemia-reperfusion injury, such as pharmacological and ischemic conditioning.
  • We will study how current cardiovascular guidelines can be implemented most effectively.

Theme leader

Gerard Rongen PhD
full professor

+31 (0)24 361 36 90

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Societal impact

More information will follow soon.

News and agenda

Organisation


Researchers Vascular damage

See the researchers related to this theme.

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Answers in Dutch

Information on our research can also be found in Dutch on the Nationale Wetenschapsagenda website. The information here answers questions asked by Dutch citizens.

Nationale Wetenschapsagenda

Research group leaders

Affiliated institutes and centers

Radboud Institute for Health Sciences

Ideally, every procedure in clinical practice and public health should take place based on proof, instead of intuition or 'experience'. Our aim is to improve clinical practice and public health.

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Radboud Institute for Molecular Life Sciences

Our main aim is to achieve a greater understanding of the molecular mechanisms of disease. By integrating fundamental and clinical research, we obtain multifaceted knowledge of (patho)physiological processes.

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