Research Themes Vascular damage

Vascular damage About theme

The mission of the theme Vascular damage is to prevent and treat cardiovascular disease by deciphering causes and consequences of vascular wall pathology.

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Vascular damage About theme

The mission of the theme Vascular damage is to prevent and treat cardiovascular disease by deciphering causes and consequences of vascular wall pathology.

The theme is centered around three lines of research:

  • Pathogenesis of atherosclerosis and its consequences
  • Pathogenesis of genetic, metabolic and endocrine causes of vascular damage
  • Personalized diagnostics and treatments of atherosclerosis and its consequences

  Objectives

  • We aim to unravel how traditional and novel cardiovascular risk factors induce a pro-atherogenic phenotype of these cells by performing in vitro and ex vivo studies on cells of the innate immune system.
  • We plan to develop and improve noninvasive vascular imaging techniques to detect vulnerable plaques and vascular inflammation.
  • We aim to develop and implement techniques to study inflammation and its impact on atherosclerosis in humans in vivo.
  • Using animal models, we aim to develop and validate biomarkers to study the impact of inflammation on progression of atherosclerosis in humans in vivo.
  • We aim to investigate the role of inflammation in the pathogenesis of the metabolic syndrome.
  • We plan to study the mechanisms by which inactivity results in cardiovascular injury and evaluate interventions to prevent or reverse this.
  • We want to improve diagnosis and treatment of the adrenal causes of hypertension and to explore mechanisms of vascular injury specifically related to these disorders.
  • We aim to explore the role of gender differences in atherogenesis.
  • We will study promising strategies to prevent ischemia-reperfusion injury, such as pharmacological and ischemic conditioning.
  • We will study how current cardiovascular guidelines can be implemented most effectively.

Theme leader

Gerard Rongen MD PhD
full professor

+31 (0)24 361 36 90

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Lines of research


Pathogenesis of atherosclerosis and its consequences

We aim to unravel the role of the immune system in the development of atherosclerosis in the context of traditional cardiovascular risk factors.

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Pathogenesis of atherosclerosis and its consequences

We aim to unravel the role of the immune system in the development of atherosclerosis in the context of traditional cardiovascular risk factors (hypertension, dyslipidemia, diabetes, obesity) as well as in the context of novel risk factors, such as physical inactivity, auto-immune diseases, hyperuricemia, gout, and infections.
 

Pathogenesis of genetic, metabolic and endocrine causes of vascular damage

We aim to unravel the pathophysiology and to improve the diagnosis and treatment of adrenal causes of hypertension, especially aldosteronism, pheochromocytoma/paraganglioma, congenital adrenal hyperplasia and hypercortisolism.

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Pathogenesis of genetic, metabolic and endocrine causes of vascular damage

We aim to unravel the pathophysiology and to improve the diagnosis and treatment of adrenal causes of hypertension, especially aldosteronism, pheochromocytoma/paraganglioma, congenital adrenal hyperplasia and hypercortisolism, in order to prevent cardiovascular complications related to these disorders. Furthermore, we investigate metabolic and genetic causes of atherosclerosis, arterial aneurysms and dissections.
 

Personalized diagnostics and treatments of atherosclerosis and its consequences

We aim to optimize personalized cardiovascular risk management based on individualized risk estimation.

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Personalized diagnostics and treatments of atherosclerosis and its consequences

We aim to optimize personalized cardiovascular risk management based on individualized risk estimation (by diagnostic innovations) and to identify new interventions to slow the progression of vascular damage and its consequences.
 

News and agenda

Organisation

Research group leaders

Affiliated institutes and centers

Radboud Institute for Health Sciences

Ideally, every procedure in clinical practice and public health should take place based on proof, instead of intuition or 'experience'. Our aim is to improve clinical practice and public health. read more

Radboud Institute for Molecular Life Sciences

Our main aim is to achieve a greater understanding of the molecular mechanisms of disease. By integrating fundamental and clinical research, we obtain multifaceted knowledge of (patho)physiological processes. read more

Radboudumc Technology Center Imaging

The Imaging Technology Center provides cutting-edge technology and service for imaging-related preclinical and clinical research questions. This covers the spectrum from molecule to man to population.

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Radboudumc Technology Center Human Performance Lab

The Human Performance Lab is able to combine the most important techniques – available at the Radboudumc and of high quality – to perform in-vivo measurements of human performance in the broadest sense of the term.

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Radboudumc Technology Center Health data

The aim of this technology center is to provide support in access to primary care data, with all related practical and scientific issues, including data storage and privacy issues.

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Radboudumc Technology Center Animal Research Facility

This technology center offers advice and support from planning up to and including the conduct of animal research on behalf of biomedical research and education.

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