Dirk Lefeber has been appointed professor of Glycosylation Disorders, with effect from 1 July 2018. Lefeber leads the research group Glycosylation Disorders in Neurology.Glycosylation is a process by which proteins are modified with different sugars. Variations in this process occur with almost every disease. Although the biological language of our DNA and proteins is already well understood, this is certainly not the case for protein glycosylation.
To gain more insight into this, Dirk Lefeber investigates patients with hereditary metabolic disorders at Radboudumc. Amongst his most important findings is the discovery of several new molecular routes for the incorporation of sugars into the muscle. Understanding such abnormalities has already led to improved diagnostics and new therapies in patient care.
VidiDirk Lefeber (Elst, 1974) studied chemistry at Utrecht University and received his MSc, with honours, in 1997. In 2001, he obtained his PhD on synthetic carbohydrate vaccines against pneumococcal bacteria. He worked as a postdoctoral researcher in infectiology at the University Medical Center Utrecht and subsequently took a staff position in the department of Neurology and the Translational Metabolic Laboratory in Nijmegen. After undertaking a four-year training programme as a laboratory specialist clinical genetics, Lefeber built a research group in the field of Glycosylation Disorders.
He is also leader of the Radboudumc Expertise Center for Disorders of Glycosylation. Lefeber has received various national and international prizes, including a Vidi grant from the NWO.
ProteinsAs professor of Glycosylation Disorders in Neurology, he will focus on the mechanisms of protein glycosylation in (hereditary) neurological diseases. The Lefeber group is developing new technologies to study the glycosylation of proteins, and will use these widely to improve medical science. Through his research, he wants to gain new insights into the process of protein glycosylation in disease, and translate these into improved person-oriented care.
Related news items
Laurens Verscheijden awarded doctorate degree 'cum laude'19 January 2022
Laurens Verscheijden of the Department of Pharmacology and Toxicology, defended his PhD thesis, entitled "Mechanistic models for the prediction of brain drug exposure and response in the paediatric population: A virtual child reaching maturation.read more
Aerobe exercise has a positive effect on brain function in Parkinson's disease patients18 January 2022
Radboudumc researchers have shown that the brain function of patients with Parkinson's disease improved with regular exercise, which seems to strengthen the connections between different brain areas, while inhibiting brain shrinkage.read more
Last call for nominations for the RIHS Awards 2021 Deadline for submission is 25 January 202218 January 2022
RIHS researchers are invited to propose candidates for the RIHS PhD Award, the Societal Impact Award, the Science Award, the Supervisor of the Year Award, and the RIHS Patient Involvement Award.read more
Cause of male infertility already present in DNA before birth17 January 2022
New mutations in DNA, which are not inherited from the father or mother but arise spontaneously before or during fertilization, can cause infertility in men.read more
Rogier Kievit and Geert Litjens both receive ERC Starting Grant of 1.5 million euros Board of Directors congratulates researchers on top grant13 January 2022
Researchers Rogier Kievit and Geert Litjens were today festively welcomed by the Board of Directors, because of the ERC Starting Grants they both received. With these European top grants, they can each design an ambitious research project and put together their own research group.read more
Improved AI will boost cancer research and cancer care Geert Litjens receives ERC Starting Grant13 January 2022
Geert Litjens from Radboud university medical center has received a European Research Council (ERC) Starting Grant.read more