Dirk Lefeber has been appointed professor of Glycosylation Disorders, with effect from 1 July 2018. Lefeber leads the research group Glycosylation Disorders in Neurology.Glycosylation is a process by which proteins are modified with different sugars. Variations in this process occur with almost every disease. Although the biological language of our DNA and proteins is already well understood, this is certainly not the case for protein glycosylation.
To gain more insight into this, Dirk Lefeber investigates patients with hereditary metabolic disorders at Radboudumc. Amongst his most important findings is the discovery of several new molecular routes for the incorporation of sugars into the muscle. Understanding such abnormalities has already led to improved diagnostics and new therapies in patient care.
VidiDirk Lefeber (Elst, 1974) studied chemistry at Utrecht University and received his MSc, with honours, in 1997. In 2001, he obtained his PhD on synthetic carbohydrate vaccines against pneumococcal bacteria. He worked as a postdoctoral researcher in infectiology at the University Medical Center Utrecht and subsequently took a staff position in the department of Neurology and the Translational Metabolic Laboratory in Nijmegen. After undertaking a four-year training programme as a laboratory specialist clinical genetics, Lefeber built a research group in the field of Glycosylation Disorders.
He is also leader of the Radboudumc Expertise Center for Disorders of Glycosylation. Lefeber has received various national and international prizes, including a Vidi grant from the NWO.
ProteinsAs professor of Glycosylation Disorders in Neurology, he will focus on the mechanisms of protein glycosylation in (hereditary) neurological diseases. The Lefeber group is developing new technologies to study the glycosylation of proteins, and will use these widely to improve medical science. Through his research, he wants to gain new insights into the process of protein glycosylation in disease, and translate these into improved person-oriented care.
Related news items
Step-up approach vs open necrosectomy for necrotizing pancreatitis18 April 2019
Another publication of the successful Dutch collaborative group on pancreatitis research with substantial contribution from Radboudumc researchers, Harry van Goor and Kees van Laarhoven.read more
Prophylactic antibiotics reduce hospitalisations and cost in head and neck cancer patients18 April 2019
In European journal of cancer Janneke Ham and colleagues showed that prophylactic antibiotics in locally advanced head and neck cancer patients treated with chemoradiotherapy did not reduce the incidence of (aspiration) pneumonias, but did reduce hospitalisations and tended to be cost-effective.read more
Nontuberculous mycobacteria and fungal co-infections Bonnie and Clyde?18 April 2019
In The European respiratory journal Jakko van Ingen and Sanne Zweijpfenning showed that 40% of patients diagnosed with nontuberculous mycobacterial pulmonary disease also meet diagnostic criteria for chronic pulmonary aspergillosis.read more
ESCMID award for groundbreaking studies on NTM disease18 April 2019
Jakko van Ingen received the ESCMID Young Investigator Award for his groundbreaking work on nontuberculous mycobacterial disease.read more
EU funded project BIOMAP led by Ellen van den Bogaard12 April 2019
Ellen van den Bogaard, theme Inflammatory diseases, leads the research on the experimental validation and functional analysis of identified biomarkers by using advanced organotypic skin models and receives a grant of €258,000.read more