News Exercise and the kidneys

26 June 2018

Coen Bongers, Thijs Eijsvogels, Maria Hopman and colleagues published an article in Physiological Reports on the effects of acute versus prolonged exercise and dehydration on kidney function and kidney damage in healthy young adults.


abstract

Exercise and dehydration may be associated with a compromised kidney function and potential signs of kidney injury. However, the kidney responses to exercise of different durations and hypohydration levels are not yet known. Therefore, we aimed to compare the effects of acute versus prolonged exercise and dehydration on estimated glomerular filtration rate (eGFR) and kidney injury biomarkers in healthy male adults. A total of 35 subjects (23 ± 3 years) were included and invited for two study visits. Visit 1 consisted of a maximal cycling test. On Visit 2, subjects performed a submaximal exercise test at 80% of maximal heart rate until 3% hypohydration. Blood and urine samples were taken at baseline, after 30 min of exercise (acute effects; low level of hypohydration) and after 150 min of exercise or when 3% hypohydration was achieved (prolonged effects, high level of hypohydration). Urinary outcome parameters were corrected for urinary cystatin C, creatinine, and osmolality. Subjects dehydrated on average 0.6 ± 0.3% and 2.9 ± 0.7% after acute and prolonged exercise, respectively (P < 0.001). The eGFRcystatin C did not differ between baseline and acute exercise (118 ± 11 vs. 116 ± 12 mL/min/1.73 m2 , P = 0.12), whereas eGFRcystatin Cwas significantly lower after prolonged exercise (103 ± 16 mL/min/1.73 m2 , P < 0.001). We found no difference in osmolality corrected uKIM1 concentrations after acute and prolonged exercise (P > 0.05), and elevated osmolality corrected uNGAL concentrations after acute and prolonged exercise (all P-values < 0.05). In conclusion, acute exercise did barely impact on eGFRcystatin C and kidney injury biomarkers, whereas prolonged exercise is associated with a decline in eGFRcystatin C and increased biomarkers for kidney injury.

publication

Impact of acute versus prolonged exercise and dehydration on kidney function and injury.
Bongers CCWG, Alsady M, Nijenhuis T, Tulp ADM, Eijsvogels TMH, Deen PMT, Hopman MTE.

Coen Bongers and Thijs Eijsvogels are both members of theme Vascular damage. Maria Hopman is member of theme Mitochondrial diseases.

Related news items


Call for nominations RIHS Awards 2017 & 2018

14 December 2018

RIHS researchers are invited to propose candidates for the RIHS PhD Award, the Societal Impact Award, the Science Award and the Supervisor of the year Award. Deadline for nominations is 14 January 2019.

read more

Bart Kiemeney among most cited researchers

13 December 2018

Bart Kiemeney made it to this year’s list of highly cited researchers. Researchers in this list are selected for their exceptional research performance and are regarded to have had a major impact on fellow scientists.

read more

Metal surgical implants can activate drugs

13 December 2018

Marja Bulte-ter Meer and Leo Schultze Kool discovered that the iron in metal surgical implants can activate drugs such as antibiotics, thus enabling targeted therapy.

read more

Annual CaRe days 8 & 9 May 2019

13 December 2018

The CaRe days provides an inspiring program for all RIHS researchers. Save the date!

read more

Radboud Talks scientific pitch competition 2019

11 December 2018

Would you like to share your research with the world? Register yourself for the pitch competition Radboud talks and tell your story in just three minutes for a live audience and jury. Application deadline: 31 January 2019.

read more

A personal touch of Elianne Bulthuis

6 December 2018

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t! This week: Elianne Bulthuis

read more
  • Go to