Coen Bongers, Thijs Eijsvogels, Maria Hopman and colleagues published an article in Physiological Reports on the effects of acute versus prolonged exercise and dehydration on kidney function and kidney damage in healthy young adults.
Exercise and dehydration may be associated with a compromised kidney function and potential signs of kidney injury. However, the kidney responses to exercise of different durations and hypohydration levels are not yet known. Therefore, we aimed to compare the effects of acute versus prolonged exercise and dehydration on estimated glomerular filtration rate (eGFR) and kidney injury biomarkers in healthy male adults. A total of 35 subjects (23 ± 3 years) were included and invited for two study visits. Visit 1 consisted of a maximal cycling test. On Visit 2, subjects performed a submaximal exercise test at 80% of maximal heart rate until 3% hypohydration. Blood and urine samples were taken at baseline, after 30 min of exercise (acute effects; low level of hypohydration) and after 150 min of exercise or when 3% hypohydration was achieved (prolonged effects, high level of hypohydration). Urinary outcome parameters were corrected for urinary cystatin C, creatinine, and osmolality. Subjects dehydrated on average 0.6 ± 0.3% and 2.9 ± 0.7% after acute and prolonged exercise, respectively (P < 0.001). The eGFRcystatin C did not differ between baseline and acute exercise (118 ± 11 vs. 116 ± 12 mL/min/1.73 m2 , P = 0.12), whereas eGFRcystatin Cwas significantly lower after prolonged exercise (103 ± 16 mL/min/1.73 m2 , P < 0.001). We found no difference in osmolality corrected uKIM1 concentrations after acute and prolonged exercise (P > 0.05), and elevated osmolality corrected uNGAL concentrations after acute and prolonged exercise (all P-values < 0.05). In conclusion, acute exercise did barely impact on eGFRcystatin C and kidney injury biomarkers, whereas prolonged exercise is associated with a decline in eGFRcystatin C and increased biomarkers for kidney injury.
Impact of acute versus prolonged exercise and dehydration on kidney function and injury.
Bongers CCWG, Alsady M, Nijenhuis T, Tulp ADM, Eijsvogels TMH, Deen PMT, Hopman MTE.
Coen Bongers and Thijs Eijsvogels are both members of theme Vascular damage. Maria Hopman is member of theme Mitochondrial diseases.
Related news items
Mark van den Boogaard received the Dr. Peter Moleman penning18 October 2018
Last week Mark van den Boogaard received the Dr. Peter Moleman penning for best article in the field of psycho-pharmacy published in the last 2 years.read more
Symposium Medical care for people with intellectual disabilities18 October 2018
On Tuesday 4 December Esther Bakker will defend her thesis ‘A Pro-active health assessment instrument for people with intellectual disabilities – towards reducing health inequities’. Prior to her defense, a symposium will be held.read more
Research with twins sheds light on predisposition to overweight11 October 2018
The genetic predisposition to overweight has a greater effect in a living environment that promotes obesity. This was the conclusion of a study conducted at University College London (UCL). Ellen van Jaarsveld was one of the researchers.read more
Major grant for development of e-health program for cardiac rehabilitation11 October 2018
Maria Hopman is creating an e-health program for cardiac rehabilitation together with a consortium of Danish and Swiss companies. The consortium has been awarded a Eurostars grant of € 1.9 million.read more
Martine Hollander, Saskia de Wildt and Rianne van Boekel have been nominated for the VIVA400 Knappe Koppen11 October 2018
Martine Hollander, Saskia de Wildt and Rianne van Boekel have been nominated for the annual VIVA400 list. They have the chance to be awarded in the category Knappe Koppen. Please vote before 6 November.read more