Rick Helmich, researcher at the Donders Center for Medical Neurosciences, receives a grant of $ 693,000 from the Michael J Fox Foundation. With this he can investigate the brain mechanisms that are responsible for the progression of Parkinson's disease. In theresearch He uses the data collected in the Personalized Parkinson Project.The grant of 693,000 dollarwill be used to investigate the cerebral mechanisms underlying disease progression in Parkinson's disease. Rick Helmich and his team will test the hypothesis that disease progression is mainly caused by a collapse of compensatory mechanisms.
To this end, they will make use of the data from the Personalized Parkinson Project (led by Bas Bloem), which is a longitudinal study in 650 Parkinson patients who will receive brain scans at baseline and after a followup of 2 years.). For the project, they will use half of this population (n=325), who will perform a motor task in the fMRI scanner at both time points. The task is optimized to detect dysfunctional activity in the basal ganglia, and compensatory activity in cortical regions (parietal cortex). They will relate changes in activity on both regions to clinical disease progression.
If they show that disease progression is mainly caused by changes in compensatory activity (rather than dysfunctional activity in the basal ganglia), then this may shift the treatment focus from cells that are gone (dopamine depletion) to cells that survive (compensation).
Related news items
High school science education program Immunology and Programming23 April 2019
International PhD candidates Joshua Gillard, Dorien Feyaerts and Yessica Rodriguez of the Laboratory of Medical Immunology (LMI), recently developed and implemented an exciting 4-day science challenge to teach vaccinology, immunology, and programming at the Lorenz Lyceum high school in Arnhem.read more
Step-up approach vs open necrosectomy for necrotizing pancreatitis18 April 2019
Another publication of the successful Dutch collaborative group on pancreatitis research with substantial contribution from Radboudumc researchers, Harry van Goor and Kees van Laarhoven.read more
Prophylactic antibiotics reduce hospitalisations and cost in head and neck cancer patients18 April 2019
In European journal of cancer Janneke Ham and colleagues showed that prophylactic antibiotics in locally advanced head and neck cancer patients treated with chemoradiotherapy did not reduce the incidence of (aspiration) pneumonias, but did reduce hospitalisations and tended to be cost-effective.read more
Nontuberculous mycobacteria and fungal co-infections Bonnie and Clyde?18 April 2019
In The European respiratory journal Jakko van Ingen and Sanne Zweijpfenning showed that 40% of patients diagnosed with nontuberculous mycobacterial pulmonary disease also meet diagnostic criteria for chronic pulmonary aspergillosis.read more
ESCMID award for groundbreaking studies on NTM disease18 April 2019
Jakko van Ingen received the ESCMID Young Investigator Award for his groundbreaking work on nontuberculous mycobacterial disease.read more