News Rick Helmich receives 693000 dollar

12 June 2018

Rick Helmich, researcher at the Donders Center for Medical Neurosciences, receives a grant of $ 693,000 from the Michael J Fox Foundation. With this he can investigate the brain mechanisms that are responsible for the progression of Parkinson's disease. In theresearch He uses the data collected in the Personalized Parkinson Project.

The grant of 693,000 dollarwill be used to investigate the cerebral mechanisms underlying disease progression in Parkinson's disease. Rick Helmich and his team will test the hypothesis that disease progression is mainly caused by a collapse of compensatory mechanisms.

To this end, they will make use of the data from the Personalized Parkinson Project (led by Bas Bloem), which is a longitudinal study in 650 Parkinson patients who will receive brain scans at baseline and after a followup of 2 years.). For the project, they will use half of this population (n=325), who will perform a motor task in the fMRI scanner at both time points. The task is optimized to detect dysfunctional activity in the basal ganglia, and compensatory activity in cortical regions (parietal cortex). They will relate changes in activity on both regions to clinical disease progression.

If they show that disease progression is mainly caused by changes in compensatory activity (rather than dysfunctional activity in the basal ganglia), then this may shift the treatment focus from cells that are gone (dopamine depletion) to cells that survive (compensation).

Related news items


A throwback to the course In the lead

18 October 2018

The RIMLS Graduate School course 'In the Lead' provides new PhD candidates with insights, tips and tricks to be at the forefront of their research and training objectives.

read more

Mark van den Boogaard received the Dr. Peter Moleman penning

18 October 2018

Last week Mark van den Boogaard received the Dr. Peter Moleman penning for best article in the field of psycho-pharmacy published in the last 2 years.

read more

UN High-Level Meeting on NCDs Oral Health Event

18 October 2018

In the context of the United Nations General Assembly 3rd High-level Meeting on NCDs, oral health was addressed during a special side event on 28 September 2018.

read more

Symposium Medical care for people with intellectual disabilities

18 October 2018

On Tuesday 4 December Esther Bakker will defend her thesis ‘A Pro-active health assessment instrument for people with intellectual disabilities – towards reducing health inequities’. Prior to her defense, a symposium will be held.

read more

Very few similarities between the brains of schizophrenia patients Research at group level says little about the individual patient

16 October 2018

Patients with a diagnosis of schizophrenia are a heterogenous group with large differences between individuals. Researchers at the Radboudumc showed that only a negligible number of identical features in the brain occur in more than two percent of patients.

read more

New collaboration with Ruhr-University Bochum to unravel how stress affects memory quality

11 October 2018

A new collaborative project with the Ruhr-University Bochum will investigate how stress hormones alter the course and quality of formation of long-term memories.

read more
  • Go to