7 March 2019

In an article appearing in the journal of the National Cancer Institute, Ioannis Sechopoulos and colleagues showed that current artificial intelligence systems can detect breast cancer in mammograms as well as a breast radiologists.


Artificial intelligence (AI) systems performing at radiologist-like levels in the evaluation of digital mammography (DM) would improve breast cancer screening accuracy and efficiency. We aimed to compare the stand-alone performance of an AI system to that of radiologists in detecting breast cancer in DM.

Nine multi-reader multi-case study datasets previously used for different research purposes in seven countries were collected. Each dataset consisted of DM exams acquired with systems from four different vendors, multiple radiologists’ assessments per exam, and ground truth verified by histopathological analysis or follow-up, yielding a total of 2,652 exams (653 malignant) and interpretations by 101 radiologists (28,296 independent interpretations). An AI system analyzed these exams yielding a level of suspicion of cancer present between 1 and 10. The detection performance between the radiologists and the AI system was compared using a non-inferiority null hypothesis at a margin of 0.05.

The performance of the AI system was statistically non-inferior to that of the average of the 101 radiologists. The AI system had a 0.840 (95% CI = 0.820-0.860) [ARR1] area under the ROC curve (AUC) while the average of the radiologists was 0.814 (95% CI = 0.787-0.841) (difference 95% CI = (-0.003-0.055))[ISS2] . The AI system had an AUC higher than 61.4% of the radiologists.

The evaluated AI system achieved a cancer detection accuracy comparable to an average breast radiologist in this retrospective setting. While promising, the performance and impact of such a system in a screening setting needs further investigation.


Stand-Alone Artificial Intelligence for Breast Cancer Detection in Mammography: Comparison With 101 Radiologists.
Rodriguez-Ruiz A, Lång K, Gubern-Merida A, Broeders M, Gennaro G, Clauser P, Helbich TH, Chevalier M, Tan T, Mertelmeier T, Wallis MG, Andersson I, Zackrisson S, Mann RM, Sechopoulos I.

Ioannis Sechopoulos is member of theme Women's cancers.

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