Meningitis is the most deadly manifestation of tuberculosis. Following a series of smaller trials that showed a benefit of high-dose rifampicin for tuberculous meningitis, Reinout van Crevel (Dept of Internal Medicine) and Rob Aarnoutse, Lindsey te Brake and Elin Svensson (Dept of Pharmacy/Pharmacology), theme Infectious diseases and global health, have received funding (4 million British Pounds) from the MRC Wellcome Trust global health trials scheme for a phase 3 randomized clinical trial evaluating high-dose rifampicin in 500 tuberculous meningitis patients in Indonesia, Uganda and South Africa.
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