go to main content
27 March 2019

Meningitis is the most deadly manifestation of tuberculosis. Following a series of smaller trials that showed a benefit of high-dose rifampicin for tuberculous meningitis, Reinout van Crevel (Dept of Internal Medicine) and Rob Aarnoutse, Lindsey te Brake and Elin Svensson (Dept of Pharmacy/Pharmacology), theme Infectious diseases and global health, have received funding (4 million British Pounds) from the MRC Wellcome Trust global health trials scheme for a phase 3 randomized clinical trial evaluating high-dose rifampicin in 500 tuberculous meningitis patients in Indonesia, Uganda and South Africa.

Besides intensified antibiotic treatment, targeting damaging inflammation might also improve survival of tuberculous meningitis patients. Following the discovery of a critical role for cerebral tryptophan metabolism (Van Laarhoven et al, Lancet Inf Dis 2018), Van Crevel and colleagues Arjan van Laarhoven, Vinod Kumar and Mihai Netea from the department of Internal Medicine, theme Infectious diseases and global health, have also received 5-year funding (4 million Euro) from the National Institute of Health (NIH, Washington) to apply a ‘multi-omics’ approach in >2000 tuberculous meningitis patients from Vietnam and Indonesia, aiming to find more effective host-directed therapy with collaborators from Boston, Vietnam and Indonesia. 
 

Related news items

KWF Roadshow 11 November 2019

10 October 2019

In which way(s) can KWF provide optimal support to oncological research and care? How can we maximize impact on our investments? These questions are pivotal in Ambition 2030: the vision that KWF developed in close cooperation with stakeholders in the oncological field.

read more

A personal touch of Frank Wagener

10 October 2019

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Frank Wagener.

read more

More than 3000 visitors at Open Day RIHS

10 October 2019

On Sunday 6 October RIHS organized an Open Day in the Weekend of Science (“Weekend van de Wetenschap”) with special guest and television presenter Klaas van Kruistum. More than 3000 visitors became a health scientist for one day and discovered how special healthcare research is.

read more

Dorine Swinkels collaborates with winners of the Nobel Prize in Physiology or Medicine

9 October 2019

The Nobel Prize in Physiology or Medicine 2019 was awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza for their discoveries of how cells sense and adapt to oxygen availability.

read more

Scaling up nanotherapy

7 October 2019

Scaling up and translating nanotherapy from pre-clinical work in small animal models to a clinical application is not trivial. Raphael Duivenvoorden, theme Renal disorders, and colleagues, published their results on translating a new nanoimmunotherapy in the journal Science Translational Medicine.

read more

A personal touch of Lise Ripken

3 October 2019

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Lise Ripken.

read more