In The European respiratory journal Jakko van Ingen and Sanne Zweijpfenning showed that 40% of patients diagnosed with nontuberculous mycobacterial pulmonary disease also meet diagnostic criteria for chronic pulmonary aspergillosis.In their cohort of patients with nontuberculous mycobacterial pulmonary disease, 60% of patients had positive Aspergillus IgG serology and 40% had both positive serology as well as positive cultures for Aspergillus fumigatus, an important fungal pathogen. Importantly, patients who proved Aspergillus IgG-positive had significantly poorer outcomes of treatment for their mycobacterial disease. In vitro, culture supernatants of Mycobacterium avium, the most frequent nontuberculous mycobacterium causing disease in the Netherlands, enhanced the growth of Aspergillus fumigatus. These two might truly behave like Bonnie and Clyde.
Nontuberculous mycobacterial pulmonary disease and Aspergillus co-infection: Bonnie and Clyde?
Geurts K, Zweijpfenning SMH, Pennings LJ, Schildkraut JA, Boeree MJ, Magis-Escurra C, van der Lee H, Verweij PE, Hoefsloot W, van Ingen J.
Jakko van Ingen and Sanne Zweijpfenning are members theme Infectious diseases and global health.
Related news items
Rob ter Horst in Dutch television broadcast Brandpunt Plus21 May 2019
In a Dutch television broadcast, called Brandpunt Plus, Rob ter Horst, PhD candidate, theme Infectious diseases and global health, explains how he records data about himself and what he hopes to find out about himself.read more
How do we keep new technology affordable to improve the lives of people?16 May 2019
Improving healthcare by means of new technological developments? We need to change the entire approach for evaluating the true impact , says Maroeska Rovers. By bringing together all stakeholders from the beginning, millions of euros can be saved.read more
Dutch Kidney Foundation Innovation grant for Tom Nijenhuis14 May 2019
Tom Nijenhuis, theme Renal disorders, received this grant for his research project “Salt supplementation in Gitelman syndrome: A simple intervention using an innovative N-of-1 trial approach”.read more
Algorithm calculates the presence and aggressiveness of prostate tumors14 May 2019
A computer program that analyzes MRI images can reliably map the presence and even the aggressiveness of a prostate tumor. This is what Radboudumc researchers and international colleagues have published in the scientific journal Investigative Radiology.read more