In The European respiratory journal Jakko van Ingen and Sanne Zweijpfenning showed that 40% of patients diagnosed with nontuberculous mycobacterial pulmonary disease also meet diagnostic criteria for chronic pulmonary aspergillosis.In their cohort of patients with nontuberculous mycobacterial pulmonary disease, 60% of patients had positive Aspergillus IgG serology and 40% had both positive serology as well as positive cultures for Aspergillus fumigatus, an important fungal pathogen. Importantly, patients who proved Aspergillus IgG-positive had significantly poorer outcomes of treatment for their mycobacterial disease. In vitro, culture supernatants of Mycobacterium avium, the most frequent nontuberculous mycobacterium causing disease in the Netherlands, enhanced the growth of Aspergillus fumigatus. These two might truly behave like Bonnie and Clyde.
Nontuberculous mycobacterial pulmonary disease and Aspergillus co-infection: Bonnie and Clyde?
Geurts K, Zweijpfenning SMH, Pennings LJ, Schildkraut JA, Boeree MJ, Magis-Escurra C, van der Lee H, Verweij PE, Hoefsloot W, van Ingen J.
Jakko van Ingen and Sanne Zweijpfenning are members theme Infectious diseases and global health.
Related news items
Guiding the surgeon real-time tumor visualization during surgery26 February 2020
Incomplete excision of tumor tissue, negatively affects the prognosis of the patient. Mark Rijpkema and colleagues are working on the development of new dual-labeled tracers and currently are implementing this into the clinic.read more
Jurgen Fütterer appointed Professor of Image-Guided Oncological Interventions26 February 2020
Fütterer is an interventional radiologist and is also Professor at the Robotics and Mechatronics Group at the University of Twente. The new professor is an expert in the field of cancer imaging techniques, image-guided interventions and robotics.read more
Arnt Schellekens appointed Professor of Addicition and Psychiatry26 February 2020
Arnt Schellekens has been appointed professor of Addiction and Psychiatry at Radboud University / Radboud university medical center with effect from 1 January 2020.read more
NWO GROOT grant for Michiel Vermeulen24 February 2020
Michiel Vermeulen, theme Cancer development and immune defense, received a 300,000 EUR grant within the NWO-GROOT consortium. He will use mass spectrometry-based proteomics and interaction proteomics applications to study proteome and gene expression dynamics during early C. Elegans development.read more