go to main content
21 February 2019

In the Journal of Antimicrobial Chemotherapy Stein Schalkwijk, Rob ter Heine, Angela Colbers and David Burger investigated how pregnant women should be treated with the anti-HIV drug darunavir.

Darunavir is pharmacotherapeutic cornerstone in treatment of HIV. During pregnancy subtherapeutic exposure may occur, leaving a whole new generation at risk for infection with HIV and transmission of drug resistance. Therefore, it was investigated what dosing regimen was most likely to result in therapeutic exposure. It was found that a twice-daily dose of 600 mg, in combination with ritonavir (100 mg) was the best dose during pregnancy.

Publication
Evaluating darunavir/ritonavir dosing regimens for HIV-positive pregnant women using semi-mechanistic pharmacokinetic modelling.
Schalkwijk S, Ter Heine R, Colbers A, Capparelli E, Best BM, Cressey TR, Greupink R, Russel FGM, Moltó J, Mirochnick M, Karlsson MO, Burger DM.

Stein Schalkwijk, Rob ter Heine, Angela Colbers and David Burger are all members of theme Infectious diseases and global health.

Related news items

New test for Lyme disease is not reliable

15 June 2022 To determine whether someone has Lyme disease, doctors in the Netherlands often use antibody tests. For some time now, so-called cellular tests have been available on the market. However, the VICTORY study published in The Lancet Infectious Diseases has found that these tests are not reliable. read more

With concerted effort, tuberculosis could be eradicated in 30 years time March 24th was World Tuberculosis Day

24 March 2022 Since 2020, the number of deaths from tuberculosis increased for the first time in a decade, caused by the COVID pandemic: fewer people had access to the right care on time. Some catching up is needed. read more

NIH grant for follow-up research on tuberculous meningitis

10 February 2022 Met subsidie van het Amerikaanse NIH gaat With a grant from the U.S. NIH, Reinout van Crevel will continue to unravel the disease process of tuberculous meningitis. read more

Scientists unite to shrink the carbon footprint in research "Flying thousands of miles for a 30 minute interview is very hard to justify during a climate crisis"

6 January 2022 read more

The European Hector Research Award in HIV 2021 awarded to Angela Colbers and David Burger

2 November 2021 On Friday 29 October 2021, during the 18th European AIDS Conference in London, the Hector Research Award for the best scientific article related to clinical or epidemiological HIV research was presented to Angela Colbers and David Burger, both working in the Pharmacy of the RadboudUMC. read more

How healthy is James Bond? - A flu to a kill No time to die: the pathogens surrounding secret agent 007

21 October 2021 James Bond made a total of 25 films between 1962 and 2021. In all those films, secret agent 007 washed his hands only twice, even though he often stayed in not so hygienic places with considerable health risks. Radboudumc researchers examined all the health risks in the 47 countries Bond visited. read more