MetaDome was recently recognized as one of the most accessed articles of 2018-2019 in Human Mutation.
Researchers of the Radboudumc have developed MetaDome to survey regions in proteins that tolerate genetic variation. This helps to address the pathogenicity of genetic variants of unknown clinical significance. Using evolutionary relationships between protein domain homologues, MetaDome aggregates variation onto “meta-domains”. These meta-domains make the genetic variation map richer than individual protein domains. MetaDome additionally visualizes variation into a tolerance landscape, indicating regions within protein-coding genes that are more, or less, tolerant to variation.
The MetaDome was a project developed by Laurens van de Wiel, Christian Gilissen, and Gert Vriend and was first available online in spring 2018. Since then, it has been used by nearly 2,500 colleagues from various institutes across 64 countries and can be accessed here.
Related news items
Evaluation of an AI system for detection of COVID-19 on Chest X-Ray images22 May 2020
In the journal Radiology RIHS researcher Keelin Murphy described how an artificial intelligence system (CAD4COVID-XRay) can identify characteristics of COVID-19 on chest x-rays with performance comparable to six independent radiologists.read more
First clinical trial with genetically modified malaria vaccine completed22 May 2020
In an innovative study, Radboudumc and LUMC jointly tested a candidate vaccine based on a genetically weakened malaria parasite. The results of this clinical trial, published in Science Translational Medicine, show that the vaccine is safe and elicits a defense response against a malaria infection.read more
New step in the development of a vaccine against malaria22 May 2020
A new vaccine based on rodent malaria parasites achieved a 95% reduction in infection of the liver in humans. An international consortium publishes the results in Science Translational Medicine.read more
Retirement of RIMLS Laboratory Assistant Nelly Mulders-Langen19 May 2020
After more than 45 years, Nelly said goodbye to "her" Radboudumc. We are going to miss her dedication and collegiality, but we wish her al the best for the future in good health.read more