9 June 2020

The first multicenter study by researchers Roel Verhoeven and Erik van der Heijden, in which the added predictive value of elastography by means of endobronchial ultrasound of mediastinal lymph nodes (EBUS) in patients with lung cancer was systematically investigated. 

The E-Predict Multicenter Study, designed and coordinated by the Radboudumc’s departments of Interventional Pulmonology and Medical Ultrasound Imaging Center (MUSIC) is the first study utilizing a validated and standardized assessment protocol to show the added predictive value of EBUS-Strain Elastography in a multicenter prospective study, conducted in five European hospitals. This study confirms our earlier single-center study that showed an association between lymph node stiffness and presence of lymph node malignancy when measured using relative strain elastography imaging with strain histogram evaluation during EBUS staging procedures. In this multicenter study, we show that strain elastography is an independent predictive variable.
Furthermore, we show that EBUS-SE can be used in conjunction with EBUS lymph node short axis size and FDG-PET imaging to help better select which nodes must be further evaluated. Using two clinical scenarios, we show how EBUS-SE can help stratify the risk of malignancy. The addition of EBUS-SE in clinical practice could increase EBUS-TBNA staging accuracy. It might help intraprocedural decision making in cases of multiple nodes within a region or unrepresentative rapid onsite cytological examination or in the decision making on further work-up after EBUS-TBNA in cases of unrepresentative cytology findings.

Predictive Value of Endobronchial Ultrasound Strain Elastography in Mediastinal Lymph Node Staging: The E-Predict Multicenter Study Results
Verhoeven R.L.J. · Trisolini R. · Leoncini F. · Candoli P. · Bezzi M. · Messi A. · Krasnik M. · de Korte C.L. · Annema J.T. · van der Heijden E.H.F.M.

In this multicenter study a system developed and validated by Roel Verhoeven and Erik van der Heijden has been used previously. Published (2019)
Optimal Endobronchial Ultrasound Strain Elastography Assessment Strategy: An Explorative Study

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