13 October 2022

Jos P.H. Smits and Ellen van den Bogaard (Dept of Dermatology, Theme Inflammatory Diseases) received a prestigious grant from the LEO Foundation, the philanthropic society of LEO Pharma that gives out competitive research grants for curiosity-driven and fundamental research on skin biology and diseases. With this grant (525.000 euro) Jos will return to Ellen’s group after his postdoctoral fellowship with Prof. Bernhard Homey (University of Dusseldorf).

The project

The project called Digging deep for filaggrin’s function in regulating epidermal barrier formation aims to improve the understanding of the emerging role of the skin protein filaggrin (FLG) in regulating and controlling epidermal cell fate and keratinocyte differentiation. Jos discovered that mutations in particular FLG domains affect other genes that are important for terminal differentiation of epidermal keratinocytes. Terminal differentiation of keratinocytes is important for the formation of the skin barrier.

In the newly awarded project, Jos wants to expand his initial findings into elaborate studies using 3D skin organoids, also called “human skin equivalents” combined with in-depth molecular and functional analyses (in collaboration with a European Network of skin scientist, and the groups of Dr. Huiqing (Jo) Zhou (Dept. Developmental Molecular Biology) and Prof. Musa Mhlanga (Dept. Cell Biology) from the Radboud University. The hope is to identify potential new targets for therapeutic interventions in AD by modifying the expression of filaggrin and thereby regulating the barrier function of the skin.

More info

Web article: https://leo-foundation.org/en/2022/10/12/dkk-30-million-to-8-researchers-setting-new-focuses-on-the-skin-and-skin-diseases/

LinkedIn: https://www.linkedin.com/posts/leo-foundation_dkk-30-million-to-8-researchers-setting-new-activity-6985930777079218177-1aAy?utm_source=share&utm_medium=member_desktop

Twitter: https://twitter.com/LEOFondet/status/1580169596669112321

  • Want to know more about these subjects? Click on the buttons below for more news.

    awards and grants

Related news items

Last RIMLS award festival Call for nominations

4 October 2022

RIMLS will award for the last time several prices to stimulate and honor our (young) researchers. You are invited to propose candidates for these awards. Deadline for submission is at the latest 10 November 2022.

read more

Grants for heart and kidney research Two awards to Radboudumc in Open Competition ENW-XS

21 July 2022

Two researchers from the Radboudumc receive a grant from the NWO within the Open Competition of the Exact and Natural Sciences. They are Thijs Eijsvogels, who studies the heart, and Pieter Leermakers, who studies the kidneys. 

read more

Grants for research on magnesium deficiency and malaria Vidis for Felix Hol and Jeroen de Baaij

1 July 2022 Radboudumc researchers Jeroen de Baaij and Felix Hol both receive an NWO Vidi grant for their research, respectively on magnesium deficiency in type 2 diabetes and on malaria.  read more

Dutch Society of Clinical Chemistry Science & Innovation Award for the team of Hans Jacobs

14 June 2022 The team of Hans Jacobs pioneers on the development of personalized diagnostics to measure minimal residual disease in patients with multiple myeloma. read more

Looking back on RIMLS New Year celebration and awards

12 January 2022 RIMLS organized a special online New Year Celebration, together looking back at the year 2021. René Bindels reviewed 2021 together with Clasien Oomen and Dagmar Eleveld-Trancikova, looked forward towards 2022 and presented the RIMLS awards and several other prizes. read more