News items Three Clinical Fellows grants from ZonMw for Radboudumc

13 December 2022

Three researchers from the Radboudumc receive a Clinical Fellowship grant from ZonMw. Dirk Geurts, Arjan van Laarhoven and Chella van der Post will receive an amount of up to 200,000 euros for their research on ketamine and depression, non-tuberculous mycobacteria and predicting gastric cancer. 

Arjan van Laarhoven - research on non-tuberculous mycobacteria 

Tuberculosis has plagued humans since prehistoric times. Despite decreased poverty and antibiotics, 1.5 million people die each year from Mycobacterium tuberculosis. The close relatives of "nontuberculous mycobacteria" also cause infections, especially in regions with little tuberculosis such as the Netherlands. Patients with mycobacterial infections sometimes suffer from uninhibited growth of mycobacteria, or on the contrary, hyperactive immune system, high fevers and tissue damage. However, we do not know how to effectively stimulate or inhibit the immune system of these patients. That's why Van Laarhoven wants to identify patients predisposed to too much or too little inflammation by testing the function of their white blood cells. He will reuse data from large international patient studies to establish a simple "bio-signature. Patients with a propensity for too much inflammation can then be considered for usual care or additional anti-inflammatories in a study. 

Dirk Geurts - research on ketamine and depression 

A new treatment, S-ketamine nasal spray, has recently become available to cope with difficult-to-treat depression. This drug can still make one out of two patients get better. Unfortunately, the treatment is very expensive and its accessibility in the Netherlands is limited. In this project, Geurts and colleagues will learn to better predict who will or will not get better from S-ketamine. He will use recent neurocognitive knowledge about S-ketamine, depression and behavioral measurements to collect data relevant specifically to these patients and this drug. He then uses machine learning procedures to achieve robust and relevant improvement in prediction, providing patients with a relevant estimate of their probability of success at the individual level. With this, in addition to information about other treatments, they can decide with their physician and environment whether or not to initiate S-ketamine treatment. 

Chella van der Post - research on predicting stomach cancer 

Patients with a congenital defect in the CDH1 gene have an increased risk of diffuse type gastric cancer (DGC). These patients are advised at young adulthood to undergo prophylactic gastric resection which is often accompanied by long-term symptoms. Microscopic foci of DGC are almost always found in these gastric resections. However, new figures show that about 60-70% of patients would not develop advanced stage gastric cancer. This research proposal aims to predict which patients are eligible for endoscopic surveillance and who should undergo gastric resection. In this research, Van der Post studies gastric tissue from different DGC stages. She also uses gastric organoids; cultured mini-organs with the structure and organization of the stomach. In these organoids, she can mimic the different steps of gastric cancer progression to unravel exactly what happens during gastric cancer development. 

About Clinical Fellowship 

With a grant of up to 200,000 euros each from the Clinical Fellows program, 15 young clinicians with doctorates will establish their own first line of scientific research. They will also create a bridge between clinic and scientific research with their research project.

A Clinical Fellowship is a personal incentive grant for a doctoral and specialized clinician who wants to continue to combine clinical work with scientific research. It allows the clinician to begin establishing his or her own initial line of research. The program is for clinicians who are still more or less at the beginning of their scientific career. 

  • Want to know more about these subjects? Click on the buttons below for more news.

    awards and grants

More information

Pauline Dekhuijzen

wetenschaps- en persvoorlichter

Related news items

Joint research in regional hospitals New research projects from promotion fund

22 November 2022

Four research projects have been honored in the promotion fund of the Radboudumc and four regional hospitals. The research projects, which are a collaboration between CWZ, Jeroen Bosch Hospital, Rijnstate, Sint Maartenskliniek and the Radboudumc will receive a contribution of 240,000 euros.

read more

Grants for heart and kidney research Two awards to Radboudumc in Open Competition ENW-XS

21 July 2022

Two researchers from the Radboudumc receive a grant from the NWO within the Open Competition of the Exact and Natural Sciences. They are Thijs Eijsvogels, who studies the heart, and Pieter Leermakers, who studies the kidneys. 

read more

Young Radboudumc researchers receive grant to engage in bio-medical and health research that is off the beaten path

16 September 2021 The ZonMw Off Road program is once again giving young scientists the opportunity to conduct innovative research in medical and/or health care. This research is off the beaten track and aims to bring about new insights and unexpected breakthroughs for healthcare and healthcare innovation. read more

KNAW Ter Meulen grants for Radboudumc researchers

10 August 2021 Four young researchers of the Radboudumc in the field of pediatrics and related fields can go abroad for a scientific research project/work visit in the coming year with a KNAW Ter Meulen grant. read more