A new study published in Nature Communications elucidates how the cancer vaccine adjuvant saponin potentiates antigen cross-presentation in dendritic cells through induction of lipid bodies.
Cancer vaccinesMartijn den Brok (photo up) and colleagues in the lab of Gosse Adema. theme Cancer development and immune defense, together with colleagues from amongst others MSD (former Intervet) strive to develop and advance cancer vaccines. Vaccine improvement for the treatment of established cancer has proven challenging. Saponin-based adjuvants are gaining ground as component in animal and human (cancer) vaccines, since they induce protective cellular immunity. Their adjuvant potency has been related to enhanced antigen cross-presentation by dendritic cells (DCs) that is crucial for cellular immunity. How these adjuvants act to induce antigen cross-presentation by DCs has remained obscure.
A team of researchers led by Gosse Adema from the Dept. of Tumor Immunology now shows that saponin adjuvant exposure enhances antigen cross-presentation through the induction of intracellular Lipid Bodies in a specific monocytic DC subset. Lipid body organelles consist of a phospholipid monolayer containing numerous unknown proteins that surrounds a core of neutral lipids, such as sterol esters or triacylglycerols. Using genetic and pharmacological interference in models for vaccination and in situ tumor-ablation, the authors demonstrate that lipid body induction is causally related to the saponin-dependent increase in cross-presentation and T-cell activation.
These novel findings aid the application of saponin-based adjuvants as cancer vaccine component, and will stimulate development of new adjuvants enforcing T-cell-mediated immunity.
PublicationSaponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation.
Related news items
1.6 million euros for Radboud university medical center in new study into shorter tuberculosis treatment5 June 2019
The study is meant to reveal whether a shorter treatment using a new combination of four different antibiotics could be as effective as the regular, longer treatment for tuberculosis (TB).read more
Frank Bosch, internist-intensivist at Rijnstate, appointed as Professor of Acute Internal Medicine10 May 2019
Rijnstate’s internist-intensivist Frank Bosch has been appointed as Professor of Acute Internal Medicine at Radboud University/Radboud University medical center/Rijnstate.read more
Ignacio Malagon, first professor of Pediatric Anaesthesiology in the Netherlands21 January 2019
Ignacio Malagon has been appointed professor of Pediatric Anaesthesiology at Radboud University / Radboud university medical center with effect from 1 January 2019. He is the first professor in this field in the Netherlands.read more
Quickly detecting actual heart attacks prevents unnecessary hospital visits Research by Radboud university medical center improves efficacy and reduces cost of cardiac care4 January 2019
Many patients who suffer from chest pain are not actually having a heart attack, making an emergency hospital visit unnecessary. Is there a way to quickly and accurately determine at home whether emergency hospital treatment is necessary?read more