Rick Wansink associated professorMy research interest is focussed on understanding the molecular pathogenesis of myotonic dystrophy type 1, one of the most abundant trinucleotide repeat diseases with a severe inheritable neuromuscular manifestation. Detailed insight in molecular mechanisms will serve as a basis for the design of molecular therapeutic strategies.
Aspects of myotonic dystrophy that are studied in my group include repeat instability of the (CTG)n repeat, structure and function of DMPK protein splice isoforms, cellular behaviour of normal-sized and expanded DMPK transcripts and dynamics of (CUG)n RNP aggregates in the cell nucleus. Antisense oligonucleotides are a promising tool to neutralize toxic (CUG)n-expanded RNA to improve disease manifestation in patients with DM1. To be able to optimize efficacy and safety of antisense oligonucleotides, normal-sized and expanded DMPK transcripts are being studied after oligo treatment in DM1 cells and in animal models. In addition, we are investigating ways to improve cellular uptake and efficacy of antisense oligonucleotides in vitro and in vivo.
Rick Wansink is associated professor at the department of Cell Biology and has a background in cell biology, biochemistry and organic chemistry.
- Coordinator, lecturer and mentor in Bachelor's and Master's programmes Medicine/Biomedical Sciences (Radboudumc) and Molecular Life Sciences/Medical Biology (RU)
- Member of the Board of Examiners of Master's programme Molecular Mechanisms of Disease (Radboudumc)
- External Examiner HAN University of Applied Sciences