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LoginBiomarkers found in COVID-19 patients support bradykinin hypothesis
29 May 2020A study into inflammatory substances in the blood of COVID-19 patients supports the hypothesis that kinins could play a role in the respiratory problems experienced by critically ill COVID-19 patients in IC. This discovery, published at MedRxiv, could lead to the development of new treatments.
Introducing OnePlanet Research Center webinar 5 June, 16:00 hrs.
29 May 2020OnePlanet Research Center develops digital technologies to create a society in which everyone can live a healthy life and has access to healthy and sustainable food. Radboudumc and Radboud University are amongst the founding partners. Find out what OnePlanet can do for you in this online session.
First clinical trial with genetically modified malaria vaccine completed
22 May 2020In an innovative study, Radboudumc and LUMC jointly tested a candidate vaccine based on a genetically weakened malaria parasite. The results of this clinical trial, published in Science Translational Medicine, show that the vaccine is safe and elicits a defense response against a malaria infection.
A tunable and injectable local drug delivery system for personalized periodontal application
11 May 2020In Journal of Controlled Release, Fang Yang and colleagues, have designed and formulated a local delivery system by loading the PLGA-drug microspheres into PIC hydrogel. This system exhibited appropriate injectability, long-term structural stability, and no obvious in vivo inflammatory response.
Fewer cancer diagnoses during the COVID-19 epidemic in the Netherlands
7 May 2020In a commentary in Lancet Oncology Iris Nagtegaal, theme Tumors of the digestive tract, published, together with Thijs Merkx, as head of the IKNL, the latest data that illustrate the impact of the pandemic on the detection of new cancer patients.
Johan van der Vlag appointed as professor of Immunology of Kidney Diseases and Transplantation
23 April 2020Johan van der Vlag is an expert in unravelling the molecular and immunological mechanisms underlying kidney disease and transplantation. His research stems from clinical questions and focuses on the development of new diagnostic/prognostic and therapeutic strategies.
Save the date for Radboud New Frontiers 2020 Prevention: the need for a leap forward
23 April 2020Although it is uncertain in what format the symposium can be organized, we continue with the preparation of the yearly Radboud New Frontiers symposium on 12 November 2020. This year’s topic is prevention. Save the date already!
Gene controls the formation of photosensitive disks in retinal cells
21 April 2020Researchers have unraveled a molecular mechanism that regulates the build-up of the photosensitive segments in the cones and rods in the retina. A protein PCARE, controls this process. These new insights, published in PNAS USA, could make a significant contribution to new therapies for eye diseases.
Study on effect of BCG vaccine on coronavirus infection in the elderly
21 April 2020Radboud university medical center and UMC Utrecht are working on a joint research project to discover whether the tuberculosis (BCG) vaccine reduces the risk of infection with the coronavirus in people aged 60 or older, or the severity of the symptoms in the event of infection.
Webinar for researchers Wednesday 22 April, 20:00 hrs
17 April 2020The corona crisis has an impact on research every day. This webinar is specifically aimed at researchers. Do you have specific topics or questions that you would like to see reflected in the webinar? Let us know via research@radboudumc.nl.
Radboudumc researchers publish new insights into COVID-19 Consequences for treatment are now being examined internationally
10 April 2020Researchers at the Radboud university medical center seem to have found an essential mechanism in the disease process of Covid-19, which has so far been overlooked. If the insight is correct, it probably has important consequences for the treatment of the disease.
Catecholamines induce trained immunity in monocytes in vitro and in vivo
10 April 2020Niels Riksen and colleagues contributed data in Circulation Research, to the understanding of pathways driving inflammatory changes in conditions characterized by high catecholamine levels, and proposed that trained immunity underlies the increased cardiovascular event rate in PHEO patients.
Stuttering DNA orchestrates the start of the mosquito’s life
9 April 2020A certain type of junk DNA that is found in mosquitoes and which repeats itself dozens of times, known as ‘satellite DNA’, has now been shown to play an essential role in the early development of mosquito embryos. Ronald van Rij and colleagues published their findings in Nature.
The ICI Amsterdam-Leiden-Nijmegen cancer vaccine consortium
7 April 2020The Chemical Immunology group from Martijn Verdoes, theme Nanomedicine, joined forces with two Organic Chemistry groups and a Chemical Biology group from Leiden University, and Immunology groups at the AmsterdamUMC and the LUMC to form a consortium to develop new cancer vaccines.
HFSP Grant for Johannes Textor
30 March 2020Johannes Textor, theme Cancer development and immune defense, has been awarded a program grant of 1 million US dollars by The Human Frontier Science Program (HFSP) to investigate how T cells navigate extremely dense environments using experiments, modeling and methods from pedestrian dynamics.
Study into better protection for healthcare workers against coronavirus infection
19 March 2020Radboudumc and UMC Utrecht will investigate whether health care workers are better protected against the coronavirus after a vaccination against tuberculosis (BCG vaccine). This vaccine does not directly protect against the coronavirus, but provides a boost to the immune system.
Differences in the placental disposition of TNF inhibitors uncovered
19 March 2020In Clinical Pharmacology and Therapeutics, researchers from the Depts. of Pharmacology and Toxicology, Obstetrics and Gynecology, and Health Evidence, in collaboration with Sanquin Diagnostic Services, investigated the placental handling of the TNF inhibitors infliximab and etanercept.
Register for pilot peer coaching for RIMLS PhD candidates
17 March 2020Obtaining your PhD can be a difficult task. In a peer coaching group (“intervisie groep”) you can discuss your (non-technical) problems or dilemmas in a structured way with peers. You can now register for the RIMLS pilot with PhD peer coaching groups. Extended deadline 15 May 2020.
Interleukin-37 plays a rol in the pathogenesis and treatment of gout
11 March 2020RIMLS researchers Leo Joosten, Viola Klück and Rosanne van Deuren, in collaboration with the Dept. of Human Genetics, discovered that rare genetic variants in interleukin-37 link the anti-inflammatory cytokine to the pathogenesis and treatment of gout.
NWO Open Competition ENW - KLEIN grant for Jenny van der Wijst
9 March 2020KLEIN grants offer researchers the possibility to realize curiosity-driven, fundamental research and elaborate creative and risky ideas. For this project, Jenny is seeking an enthusiastic postdoc to join her team working on ion channels.
FET-OPEN grant for Toin van Kuppevelt and Willeke Daamen
6 March 2020A grant of 592 kEuro has been awarded to Toin van Kuppevelt and Willeke Daamen, theme Reconstructive and regenerative medicine, for a Horizon 2020 FET-OPEN project entitled “Heparin and heparan sulphate: from sequence determination to therapeutic strategies for Parkinson’s disease”.
Plugging the gap ZonMw/Health Holland grant
3 March 2020RIMLS en RIHS researchers Willeke Daamen, Frank Vandenbussche, Joris van Drongelen, Toin van Kuppevelt and Janneke Grutters have been granted 1.3 million euro for the development and evaluation of a new technology to prevent premature rupture of fetal membranes (iPPROM).
Guiding the surgeon real-time tumor visualization during surgery
26 February 2020Incomplete excision of tumor tissue negatively affects the prognosis of the patient. RIHS researcher Mark Rijpkema and colleagues are working on the development of new dual-labeled tracers and currently are implementing this into the clinic.
NWO open call GROOT grant for Michiel Vermeulen
24 February 2020Michiel Vermeulen, theme Cancer development and immune defense, received a 300,000 EUR grant within the NWO-GROOT consortium. He will use mass spectrometry-based proteomics and interaction proteomics applications to study proteome and gene expression dynamics during early C. Elegans development.
Researchers investigate how stem cells affect the immune system
18 February 2020RIMLS researchers Irma Joosten and Renate van der Molen, participating in an European study into the treatment of brain damage in premature babies. Is it possible to limit or even partly repair the damage with stem cells? They focus primarily on the effect of those stem cells on the immune system.
Five ZonMw ‘Off Road’ grants for Radboudumc researchers
17 February 2020Benoit Besson, Annemarie Boleij, Jonne Doorduin, Jorik Nonnekes and Sara Roig Merino have each received an ZonMw ‘Off Road’ grant of €100,000. The grants are intended for biomedical health researchers who dare to go off the beaten track in their search for new insights and unexpected breakthroughs.
