News items related to the Radboud Institute for Molecular Life Sciences.
A personal touch of Marlies Cornelissen31 October 2019
In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Marlies Cornelissen.
Collective cancer invasion forms an integrin-dependent radioresistant niche29 October 2019
Anna Häger and Peter Friedl, theme Cancer development and immune defense, identified a new niche of cancer cell survival and developed an integrin inhibition therapy to overcome resistance. They have published their results in JEM.
Algorithm to predict which cancer patients benefit from immunotherapy29 October 2019
Rik Lindeboom and Michiel Vermeulen, theme Cancer development and immune defense, have developed an algorithm that can predict which cancer patients are more likely to benefit from immunotherapy. This new technology’s potential is described in Nature Genetics.
X² Ambition Award for Sandra Heskamp28 October 2019
This award is intended for 'coming women’: young, ambitious women at a stage of their careers where they make important career choices. This prize is especially for women who show exemplary behaviour within the organization where they work, but also outside their organization.
A personal touch of Mariya Chernyavska24 October 2019
In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Mariya Chernyavska.
Two projects granted for Experimental Rheumatology22 October 2019
Osteoarthritis is the most prevalent and debilitating joint disease worldwide but no cure has been developed yet. Recent findings show that low grade inflammation within the OA joint contributes to the pathophysiology and clinical symptoms. Both Peter van Lent and Fons van de Loo received a grant.
Radboud Bioinformatics Xmas event 16 December21 October 2019
The CMBI is organizing the event of the year for all bioinformaticians throughout Radboud University and Radboudumc to give you the opportunity to bring forward the biggest challenges in your research to expert bioinformaticians and pave the way for real solutions.
KWF Roadshow 11 November 201910 October 2019
In which way(s) can KWF provide optimal support to oncological research and care? How can we maximize impact on our investments? These questions are pivotal in Ambition 2030: the vision that KWF developed in close cooperation with stakeholders in the oncological field.
Dorine Swinkels collaborates with winners of the Nobel Prize in Physiology or Medicine9 October 2019
The Nobel Prize in Physiology or Medicine 2019 was awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza for their discoveries of how cells sense and adapt to oxygen availability.
Scaling up nanotherapy7 October 2019
Scaling up and translating nanotherapy from pre-clinical work in small animal models to a clinical application is not trivial. Raphael Duivenvoorden, theme Renal disorders, and colleagues, published their results on translating a new nanoimmunotherapy in the journal Science Translational Medicine.
RIMLS 25 years jubilee festival The Future is Yesterday3 October 2019
Together with more than 250 colleagues and alumni we celebrated 25 years of research into the molecular mechanisms of disease. During this exciting and informal event, we not only took a trip down memory lane, but also looked ahead to the next 25 years and beyond…...
New mitochondrial DNA maintenance disease uncovered1 October 2019
The group of Hans Spelbrink, theme Mitochondrial diseases, and colleagues, has identified and characterized mutations in the mtDNA maintenance gene SSBP1 in families with optic atrophy and foveopathy. This paper is now online in The Journal of Clinical Investigation.
A personal touch of Juan Pablo Rigalli26 September 2019
In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Juan Pablo Rigalli.
Charity event for children with a diaphragmatic defect26 September 2019
For the third year in a row, Rotary Ridderkerk - de Waal organised a golf tournament, dinner and auction to raise research funds for children with congenital diaphragmatic hernia. At the end of the day, a cheque worth € 51,000 was handed over to Sanne Botden and Willeke Daamen.
The effect of an invasive approach on final infarct size and clinical outcome up to 1 year24 September 2019
Niels van Royen published in JACC: Cardiovascular Interventions, that patients with transient STEMI have limited infarction and well-preserved myocardial function in general, and delayed or immediate revascularization has no effect on functional outcome and clinical events up to 1 year.
Radboud-led collaboration generates innovative candidate drug against malaria19 September 2019
A molecule once designed to cure the skin disease psoriasis appears to be particularly effective against malaria. The antimalarial properties were revealed thanks to one researcher’s inspired hunch when the psoriasis drug discovery programme came to a dead end.
Radboud university medical center opens first healthcare AI labs19 September 2019
These are the first two ‘labs’ in the east of the Netherlands that are part of the national Innovation Center for Artificial Intelligence and the first health labs. With these two initiatives, Radboudumc and its partners are investing heavily in the application of AI to health care.
Artificial intelligence for renal tissue assessment16 September 2019
Meyke Hermsen and Jeroen van der Laak, present an alternative approach, featuring a convolutional neural network for multi-class segmentation of periodic acid–Schiff-stained kidney tissue sections. Their work was published in the Journal of the American Society of Nephrology.
H2020 grant for a new EATRIS flagship project on personalised medicine6 September 2019
EATRIS obtained funding for a new flagship project for sustainability and personalised medicine: EATRIS-Plus. Alain van Gool, Peter-Bram ‘t Hoen and Ariaan Siezen are co-PI’s and receive approximately 550 k€ from this 5M€ Horizon2020 infrastructure development grant.
A personal touch of Lenneke Cornelissen5 September 2019
In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Lenneke Cornelissen.
New technique boosts preclinical antibody research30 August 2019
Martijn Verdoes, theme Nanomedicine, and Bas van der Schoot, theme Cancer development and immune defense, developed a technique to engineer and produce antibodies quickly, easily and cheaply. The researchers published their results in the open access journal Science Advances.
Help us evaluate the improved design of the lab U-workspace in practice29 August 2019
We have built two examples of the redesigned lab U-workspaces in the Research Tower (M850) on the 6th and 7th floor. These so-called ‘mockups’ are experimental setups that enable all potential users to evaluate the re-design of the workspaces in practice.
Publication in Blood on CD37 mutations in lymphoma26 August 2019
Suraya Elfrink, in Annemiek van Spriel's research group Immune cell signaling, theme Cancer development and immune defense, published a manuscript in Blood reporting that tetraspanin CD37 is frequently mutated in patients with diffuse large B cell lymphoma occurring at immune-privileged sites.
University Teaching Prize for Joost Hoenderop26 August 2019
The prize is a reward for excellent teaching and consists of a certificate and a sum of €3000, two-thirds of which is to be spent on educational activities. The prize was awarded on Monday 2 September when the 2019-2020 Academic Year was opened.
Publication in PNAS on dissecting EEC syndrome using single-cell RNA-seq22 August 2019
PhD candidates Eduardo Soares and Quan Xu in Jo Huiqing Zhou’s group in Molecular Developmental Biology, theme Reconstruction and regenerative medicine, have published a paper in PNAS on the disease mechanism of EEC syndrome using single-cell RNA-seq technology and patient-derived iPSCs.
NWO grant for a tissue-generating patch to close diaphragmatic defects21 August 2019
Willeke Daamen and Toin van Kuppevelt, theme Reconstructive and regenerative medicine, were recently awarded a 690 k€ grant by NWO, domain Applied & Engineering Sciences, for the development of advanced patches for closure of diaphragmatic defects in children with congenital diaphragmatic hernia.
Front cover Human Mutation21 August 2019
The MetaDome web server build to interpret genetic variants based on genetic tolerance and homologous protein domains is featured on the Cover of Human Mutation. MetaDome was developed by Laurens van de Wiel, Coos Baakman, Daan Gilissen, Joris Veltman, Gert Vriend and Christian Gilissen,
NWO grant to develop new biomaterials for improved regeneration of bone defects20 August 2019
Sander Leeuwenburgh, theme Reconstructive and regenerative medicine, and Roland Brock, theme Nanomedicine, were recently awarded with a grant of 581 k€ by NWO, domain Applied & Engineering Sciences, to develop new biomaterials for improved regeneration of bone defects.