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New way of diagnostics detects 'undetectable' genetic defects

15 April 2021

Research provides guidance for global application

Vici grant for Michiel Vermeulen Reading the epitranscriptome

15 April 2021

Michiel Vermeulen, theme Cancer development and immune defense, has been awarded a Vici grant from the Netherlands Organisation for Scientific Research (NWO), one of the largest personal scientific awards in the Netherlands.

2.5 million Euros for cancer research into ovarian cancer and immunotherapy

15 April 2021

The Radboudumc receives 2.5 million Euros from the Dutch Cancer Society (KWF) for three studies to ensure oncological progress during COVID-19 period.

Anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity

14 April 2021

Cell reports publication by Charles Dinarello and Mihai Netea and colleagues, theme Infectious diseases and global health, shows that the anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity.

Miljoenen voor kennis- en investeringsconsortium op het gebied van AI

14 April 2021

Een kennis- en investeringsconsortium met het Radboudumc heeft acht miljoen euro subsidie gekregen om innovatie op het gebied van Artificial Intelligence (AI) versneld naar de markt te brengen.

Genetische pleister ‘remt’ blindheid in patiënten met Usher syndroom Leidse ProQR bouwt onderzoek Radboudumc verder uit

14 April 2021

Het Leidse biotechbedrijf ProQR Therapeutics presenteerde deze week positieve resultaten van een klinische fase I/II studie met het molecuul QR-421a, een molecuul dat in de vroegste fase is ontwikkeld door onderzoekers van het Radboudumc

Freezer Challenge by Teun Bousema

13 April 2021

13 research groups, 1280 boxes discarded, 26% less energy consumption, and two winners. Watch our short video with the results of the Radboud Freezer Challenge. It is safe, and you can do it anytime. Warm up your freezers to cool down the planet!

Cross communication between nephron segments by extracellular vesicles

13 April 2021

In the FASEB Journal, Joost Hoenderop and other researchers, theme Renal disorders, demonstrated that purinergic signaling and αENaC mRNA expression is controlled by extracellular vesicles flowing along the nephron segments.

Autoantibody profiles in systemic sclerosis a comparison of diagnostic tests

8 April 2021

The research of Ruben Smeets and colleagues in Autoimmunity showed high concordance of prevalent SSc-specific autoantibodies between different diagnostic assays. Further standardisation for low prevalent SSc-specific and SSc-associated autoantibodies is needed.

Current overview of intriguing RNA therapies

8 April 2021

In an article in EMBO Molecular Medicine, researchers from Radboudumc, together with European colleagues, provide an up-to-date overview of the (im)possibilities of these intriguing RNA therapies.

RIMLS PhD retreat. Save the date(s)! 8 & 9 July or 14 & 15 Oct 2021

1 April 2021

How much are we all longing for an old-fashioned RIMLS PhD retreat full of science, workshops and fun! In normal years, the RIMLS 2-day PhD retreat is held in April. This year, however, it is not yet definitive. Final decision will follow in May.

Bifunctional protein PCBD2 operates as a co‐factor for hepatocyte nuclear factor 1β and modulates gene transcription.

30 March 2021

Lotte Tholen, theme Renal disorders, and colleagues published in the FASEB Journal that PCBD1 and PCBD2 exert different effects on HNF1β‐mediated transcription.

Bifunctional protein PCBD2 operates as a co‐factor for hepatocyte nuclear factor 1β and modulates gene transcription.

30 March 2021

Lotte Tholen, theme Renal disorders, and colleagues published in the FASEB Journal that PCBD1 and PCBD2 exert different effects on HNF1β‐mediated transcription.

One drop of blood brings progression of multiple myeloma into better view

26 March 2021

Sensitive test opens door to personalized therapy

Rare and complex urology: Clinical overview of ERN eUROGEN

25 March 2021

Wout Feitz and colleagues, theme Reconstructive & Regenerative Medicine, Department of Urology, Division of Pediatric Urology (Radboudumc Amalia Children’s Hospital) publish an article in European Urology which well indicates the impact of ERN developments.

Immunomodulatory aged neutrophils are augmented in blood and skin of psoriasis patients

24 March 2021

A new study by Radboudumc researchers show that Psoriatic patients have a unique neutrophil profile in circulation, and two distinct neutrophils subsets are present in psoriatic skin. The results are published in the Journal of Allergy and Clinical Immunology on the 19th of March. 

Marie Curie Fellowship for Elena Macías Sánchez

24 March 2021

Elena Macías Sánchez has been awarded with a MSCA-IF to develop her project in the department of Biochemistry, RIMLS.

Intensive writing week - online from Radboud in'to Languages

18 March 2021

This course is for early-career researchers, such as PhD candidates and postdocs, who are writing an article or thesis.

Michiel Schreuder appointed Professor of Pediatric Nephrology

18 March 2021

Michiel Schreuder appointed full professor of Pediatric Nephrology as of 16 January 2021.

Phase I/II COVID-19 vaccine trial in humans

17 March 2021

Benjamin Mordmüller starts this clinical research at Radboudumc with a European Commission-funded ABNCoV2 vaccine research project.

Joining forces with patient communities to drive FAIR data

17 March 2021

Nawel van Lin created a new animation, which was presented during the event on Duchenne data sharing to spread awareness of the benefits of FAIR.

Iron Expertise Center will be transferred from Radboudumc to Sanquin

17 March 2021

The strong connection with Radboudumc will be maintained by current head of the expertise center Dorine Swinkels, who will be employed by both Sanquin and Radboudumc.

Discovery of new protein with an important role in atherosclerosis

11 March 2021

Atherosclerosis is the underlying condition that causes heart attacks and strokes. Researchers at Radboudumc in the Netherlands have discovered a protein that appears to play an important role in atherosclerosis. The protein is called Prosaposin.

New Frontiers symposium on Translational Glycoscience 18 & 19 November 2021

11 March 2021

Save the date for our annual New Frontiers Symposium on current advances in glycobiology. Deadline for registration is 1 September 2021.

Benjamin Mordmüller

10 March 2021

Ever since he realized about three decades ago that science was his fate, fighting neglected tropical diseases has become his fierce battle. When he’s not actively saving the world, he’s a devoted musician. Let’s get to know this new member of our research family better.

Academic Alliance Fund (AAF) grant for Cansu Yanginlar and Johan van der Vlag

10 March 2021

They received 100 kEuro for their project “NETworking: Deciphering the pathologic properties of the neutrophil in COVID-19, ANCA-associated vasculitis (AAV), and systemic lupus erythematosus (SLE).

Researchers grow most lifelike bone organoid to date Greatly increasing our understanding of bone formation and bone diseases

9 March 2021

Researchers from Radboudumc and Eindhoven University of Technology have interwoven various bone cells into an 'organoid' that can independently make new, hard bone tissue. It’s the most complete 3D model of bone formation to date. Peaked your interest? Read more!

Arterial wall inflammation and increased hematopoietic activity in patients with primary aldosteronism

4 March 2021

Niels Riksen and colleagues identified increased inflammatory activity in patients with primary aldosteronism.

ADP/ATP carrier inhibitor characteristics identified

3 March 2021

Tom Schirris and colleagues, published an article entitled “Characterization of drug-induced human mitochondrial ADP/ATP carrier inhibition” in Theranostics.

Online, socially distanced, or pre-pandemic style... “In the Lead” is always inspiring and helpful. By Özlem Bulut

25 February 2021

Every new RIMLS PhD candidate shares one common experience: an amazing 2-day retreat where you make friends, discover yourself, and get inspired. At least, that was the case pre-pandemic. No more communal retreats in an old convent, but the course still continues helping new PhDs online.

Less inflammation with a traditional Tanzanian diet than with a Western diet

18 February 2021

Study shows differences between western and traditional diet.

Trained immunity: a tool for reducing susceptibility to and the severity of SARS-CoV-2 infection

17 February 2021

In a review in Cell Mihai Netea, Frank van de Veerdonk, Reinout van Crevel and Jorge Dominguez Andres propose that induction of trained immunity by whole-microorganism vaccines may represent an important tool for reducing susceptibility to and severity of SARS-CoV-2.

Dutch Kidney Foundation Innovation Grant for Tom Nijenhuis and Jeroen de Baaij

17 February 2021

This innovation grant was awarded for their project “A sweet deal: repurposing SGLT2i for renal hypomagnesemia”.

Dysfunction of the ciliary ARMC9/TOGARAM1 protein module causes Joubert syndrome

16 February 2021

Brooke L. Latour, theme renal disorders, published an interesting article on the cause of the Joubert syndrome in the Journal of Clinical Investigation.

Marie Curie Fellowship for Juan Pablo Rigalli

11 February 2021

RIMLS postdoc Juan Pablo Rigalli, theme Renal disorders, is awarded with a Marie Curie Fellowship from the European Commission to study the application of extracellular vesicles in precision pharmacotherapy.

Research Integrity Round College Tour

11 February 2021

During the online College Tour on 9 March 2021, Dorine Swinkels, Maroeska Rovers and Marcel Olde Rikkert will be there to answer all of your burning questions. The session will be hosted by Dr. Jos Kole.

Organize an ENABLE satellite event and be part of the organizing team as ENABLEr

11 February 2021

Become part of the ENABLE network by submitting a proposal for an ENABLE satellite event. Deadline before 01 March 2021

Combinatorial transcription factor activities on open chromatin induce embryonic heterogeneity in vertebrates

9 February 2021

Gert-Jan Veenstra and Simon van Heeringen published in the Embo Journal. Their results show that transcription factors cooperate in a combinatorial fashion in generally open chromatin to orchestrate zygotic gene expression.

Horizon 2020 ERICA project approved by the EU

4 February 2021

In total there are 24 thematic ERNs. The Radboudumc participates in 14 networks. We are proud to say that two of these networks are coordinated from Radboudumc: ERN GENTURIS by Nicoline Hoogerbrugge and ERN eUROGEN by Wout Feitz.

Predicting protein condensate formation using machine learning

4 February 2021

Guido van Mierlo, Jurriaan Jansen, Simon van Heeringen and Michiel Vermeulen and colleagues recently published in Cell Reports that predicting protein condensate formation can be done using machine learning.

Vacancy in RIMLS PhD Council

3 February 2021

Enthusiastic PhD candidates wanted to expand the RIMLS PhD Council, which consists of an active group of young researchers and different tasks are carried out in subgroups. Would you like to organize social or scientific activities for PhD candidates together with colleagues? Make your voice count!

ZonMw grants to study optimal use of COVID-19 vaccines in patients with impaired immune systems

3 February 2021

How do people with reduced immunity, especially kidney patients, react to a COVID-19 vaccination? And how can patients with peripheral arterial disease be helped by DNA testing? Our researchers received grants from ZonMw to make these studies possible.

Establishing the biggest database of pathology images to accelerate the development of artificial intelligence in medicine.

2 February 2021

A new consortium of the EU Innovative Medicines Initiative (IMI) aims to establish the biggest database of pathology images to accelerate the development of artificial intelligence in medicine.

Invitation ENABLE 2021 online event Registration is open

27 January 2021

This 4th ENABLE Life Sciences Symposium, entitled "Exploring life dynamics: in and out of equilibrium," will be fully online on May 12 - 14, 2021.

New malaria mosquito is emerging in African cities

27 January 2021

A new urban mosquito is widespread in the Horn of Africa and is highly susceptible to local malaria parasites: a publication in Emerging Infectious Diseases.

Increase radio- and immunotherapy efficacy by targeting hypoxia

21 January 2021

In a paper recently accepted by Clinical Cancer Research, Daan Boreel, together with Paul Span, Sandra Heskamp, Gosse Adema and Jan Bussink, reviews the therapeutic potential of decreasing the lack of oxygen (hypoxia) often found in solid tumors.

New research through grants for Radboudumc researchers

14 January 2021

Several researchers at the Radboudumc have received grants to start new studies, including on rare diseases, liver disease and cancer metastases. These are grants from the Dutch Research Council, European Joint Programme on Rare Diseases and the Gastric Liver Disease Foundation.

RIMLS online award ceremony proudly presenting the winners

13 January 2021

In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony. 

Dutch Digestive Foundation grant for Joost Drenth

13 January 2021

Joost Drenth, theme Renal disorders, received a Dutch Digestive Foundation grant in cooperation with his colleagues from Amsterdam UMC and Leiden UMC.

Koen van den Dries received ENW-XS grant from the NWO

7 January 2021

Koen van den Dries has received an ENW-XS grant from the NWO for his project titled: Small differences, large impact: how actin variants differentially control cancer cell migration.

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