A single protein complex balances the very first lineage decision of cells in human: towards foetus or placenta21 June 2022
The international group of researchers spearheaded by Dick Zijlmans and Hendrik Marks together with colleagues from KU Leuven, examined which proteins are associated with the chromatin and how this affects gene transcription.
‘Happiness is in the small things’ a throwback to the valedictory lecture of René Bindels21 June 2022
In a full Aula he outlined his scientific journey of the past 40 years that led to the groundbreaking discovery of the transient receptor potential ion channel TRPV5 that plays an essential role in maintaining the calcium balance in our body.
The consortium 'OAInject' has been awarded a grant within NWO's 'Perspectief' program for research into the treatment of osteoarthritis7 June 2022
The 'OAinject' consortium, in which Peter van der Kraan is involved as one of the Work Package leaders, received the NWO 'Perspectief' grant to develop new diagnostic tools that determine exactly what form of osteoarthritis someone has to enable tailor-made treatments.
Field research on malaria vaccine offers unexpected surprise23 May 2022
Field research on the effectiveness of a malaria vaccine, came up with unexpected results for an international group of researchers including Benjamin Mordmüller of Radboudumc. The vaccine evokes a broader response against malaria proteins than there are in the vaccine.
The future of laboratory animal research More attention to living conditions of laboratory animals16 May 2022
On May 9, a meeting took place at the Radboudumc as a result of the launch of the Dutch Transparency Agreement on Animal Testing. The Radboudumc is one of the twenty signatories and has thus committed itself to openly and transparently communicate its vision and policy with regard to animal testing.
Renee Salz wins prize for best presentation10 May 2022
Renee Salz won the award for best oral presentation during the Rolduc genetics retreat, organized by the Dutch and Belgian Societies of Human Genetics in Brugge. Her presentation was titled "Variant effect prediction based on long read transcriptomes".
Combining targeted radionuclide therapy and immune checkpoint inhibition for cancer treatment4 May 2022
Simone Kleinendorst, Sandra Heskamp and colleagues, theme Rare cancers, published in Clinical Cancer Research about their research on combined radionuclide therapy and immunotherapy for cancer treatment.
European grants for groundbreaking Radboudumc research Professors Roshan Cools and Peter Friedl receive ERC Advanced Grant26 April 2022
The European Research Council (ERC) is awarding grants to Roshan Cools and Peter Friedl, both professors at Radboudumc. While Cools will investigate how brains control behaviour in (stressful) situations, Friedl will work on developing a new cancer therapy.
Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation published in Cellular and Molecular Life Sciences20 April 2022
Lisa Huis in ‘t Veld, Nataschja Ho and colleagues from the team of Gosse Adema published in Cellular and Molecular Life Sciences that Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation.
Camille Le Gall reports an efficient approach for delivery of poorly soluble tumor antigens to human cDC1s20 April 2022
Camille Le Gall published about an efficient targeting of NY-ESO-1 tumor antigen to human cDC1s by lymphotactin results in cross-presentation and antigen-specific T cell expansion in the Journal of Immunotherapy of Cancer.
A "QR code" to read metabolism inside prostate cells: labeled extra-cellular citrate12 April 2022
In a recent publication in the Proceedings of the National Academy of Sciences USA, Frits van Heijster and his colleagues describe investigations to uncover which carbon sources and metabolic pathways are used by epithelial cells of the prostate to sustain high luminal citrate levels.
Neolithic made us taller and more intelligent, but more prone to heart disease How modern European populations have evolved over the past 50,000 years6 April 2022
After the Neolithic, European populations showed an increase in height and intelligence, reduced skin pigmentation and increased risk of cardiovascular disease due to genetic changes that lowered concentrations of 'good' HDL cholesterol.
Joyce Aarts and colleagues published in Scientific Reports about the role of TGF-β1 in (experimental) arthritis30 March 2022
Joyce Aarts, theme Inflammatory diseases, and her colleagues published in Scientific Reports, that local inhibition of TGF-β1 signaling improves Th17/Treg balance but not joint pathology during experimental arthritis.
ERC Starting Grant awarded to Jeroen de Baaij17 March 2022
Jeroen de Baaij, kidney researcher the Radboudumc, receives an ERC Starting Grant worth 1.5 million euros. He will use this grant to improve the diagnosis and treatment of severe magnesium deficiencies, which can lead to epileptic seizures and muscle cramps.
Wanted: PhDs or postdocs to organize ENABLE symposium in Cologne in November 202315 March 2022
Did you ever consider organising a scientific symposium? Do you want to improve your CV, collaborate with international PhD candidates, or get in touch with biomedical companies? We are now looking for the two representatives of Radboudumc.
ERC Proof of Concept Grant for Martijn Verdoes8 March 2022
Martijn Verdoes, group leader Chemical Immunology at the department of Tumor Immunology, has been awarded an ERC Proof of Concept (PoC) Grant. The ERC PoC Grants are designed to support ERC grantees with the commercial or societal application of the results of their funded research.
Immunogenetic studies in diverse populations are essential Clear immunological differences between populations in Europe and Africa15 February 2022
Genetic factors that partly determine host defenses sometimes differ significantly between people and populations. This is shown in a publication in the American Journal of Human Genetics by researchers from the Netherlands, Tanzania and India.
Arnhem Nijmegen: top region in Health, High-Tech and Energy10 February 2022
Projects in the Arnhem Nijmegen region can expect millions of extra euros in the coming years. This will be used for, amongst other things, the circular economy and pioneering applications in the fields of Health, High-tech and Energy.
What does the shingles vaccine teach us about other vaccines? Investigating the role of trained immunity27 January 2022
The vaccine for shingles, a condition that causes itching, pain, and blisters, is 90% effective, even in elderly. This is remarkable, since most vaccines offer less protection in elderly. Radboudumc is investigating why this vaccine works so well and how it might help us to develop better vaccines.
Laurens Verscheijden awarded doctorate degree 'cum laude'19 January 2022
Laurens Verscheijden of the Department of Pharmacology and Toxicology, defended his PhD thesis, entitled "Mechanistic models for the prediction of brain drug exposure and response in the paediatric population: A virtual child reaching maturation.
Looking back on RIMLS New Year celebration and awards12 January 2022
RIMLS organized a special online New Year Celebration, together looking back at the year 2021. René Bindels reviewed 2021 together with Clasien Oomen and Dagmar Eleveld-Trancikova, looked forward towards 2022 and presented the RIMLS awards and several other prizes.
Hans Jacobs receives KWF Proof-of-Concept grant to develop personalized cancer diagnostics11 January 2022
The Dutch Cancer Society (KWF) launched a new funding program to support successful KWF researchers to translate their results into clinical practice. Hans Jacobs and his team developed a personalized blood-test to measure minimal residual disease (MRD) in patients with multiple myeloma.
Novel high-resolution targeted sequencing of the cervicovaginal microbiome published in the Journal of BMC Biology28 December 2021
This project of William Melchers, Karolina Andralojc and Mariano Molina describe a novel sequencing method to profile the cervicovaginal microbiome at the species level and with the potential to elucidate the role of the microbiome in hrHPV-induced carcinogenesis.
What can we learn from rural Tanzanian food?23 December 2021
What we eat affects our bodies. A diet high in plant based products and low in fat offers health benefits and prevents lifestyle diseases, such as cardiovascular disease. This is what Quirijn de Mast shows based on his research in Africa.
Radboudumc receives 2.6 million Euro from KWF for cancer research22 December 2021
The Dutch Cancer Society (KWF) is awarding funds with a total of more than 2.6 million euros to five new research projects. The awards are part of the latest round of funding from KWF, in which almost 27 million euros is being allocated to Dutch cancer research. The projects will start in mid-2022.
NWO OTP grant to investigate fibrotic diseases with organ-on-a-chip technology22 December 2021
Wouter Verdurmen & Peter van der Kraan have been awarded with a grant by the Netherlands Organisation for Scientific Research (NWO-OTP) to develop and employ innovative organ-on-a-chip models to investigate fibrotic diseases, with a particular focus on systemic sclerosis.