News items related to the Radboud Institute for Molecular Life Sciences.
Lowering cholesterol is not enough to reduce hyperactivity of the immune system14 June 2019
In Cell Metabolism, Siroon Bekkering, theme Vascular damage, and colleagues, provides a novel potential explanation for the residual cardiovascular risk, related to persistent activation of the immune system in patients with hypercholesterolemia who are treated with statins.
A personal touch of Johan van der Vlag13 June 2019
In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Johan van der Vlag.
Peter van der Kraan new theme leader Inflammatory diseases13 June 2019
It is our pleasure to introduce Peter van der Kraan from the Dept. of Rheumatology, as the new leader of our theme Inflammatory diseases. As such he will be the successor of Irma Joosten who has done an outstanding job in the last years as theme leader, for which we thank her wholeheartedly.
Studying the function of liver cancer genes in mini-organs24 May 2019
Michiel Vermeulen, theme Cancer development and immune defense, and colleagues, have developed a human model in which they use organoids, or mini organs, to study the function of specific genes that are mutated in liver cancer. Their results were published in the scientific journal Cell Stem Cell.
Three VIDI grants for RIMLS researchers24 May 2019
Matthijs Jore, Daniele Tauriello and Johannes Textor are each to receive up to 800,000 euros to develop an innovative research theme and to build up their own research group. NWO is awarding the Vidi grant as part of the Innovational Research Incentives Scheme.
Graduate school news Adjusted PhD guidelines23 May 2019
It should be emphasized that the quality, and not the number of chapters, determines the assessment by the manuscript committee. To avoid the wrong emphasis on quantity, it is not recommended to have more than three publishable chapters in the thesis.
Universal tumor BRCA1/2 testing of ovarian cancer13 May 2019
Marjolijn Ligtenberg, Janet Vos and Nicoline Hoogerbrugge, assessed the feasibility of a workflow for universal tumor DNA BRCA1/2 testing of all newly diagnosed OC patients as prescreen for PARPi treatment and cancer predisposition testing. They have published their findings in the JNCI.
A cozy relationship; the enhancer landscape of embryonic stem cells13 May 2019
In Nature Cell Biology, Yaser Atlasi, Wout Megchelenbrink and colleagues from the group of Henk Stunnenberg, theme Cancer development and immune defense, published a combination of experimental and bioinformatic approaches to study enhancer regulation in different states of embryonic stem cells.
Special microscope films how gateway in kidney cells opens and closes6 May 2019
One of the gateways in the kidney cell virtually exclusively allows calcium through. But how does that calcium channel work exactly? What does the molecular machine look like that makes sure that the channel opens and closes?
Toughened calcium phosphate bone cements using PVA Fibers2 May 2019
Nathan Kucko and Sónia de Lacerda Schickert, and colleagues, published in ACS Biomaterials Science and Engineering that the incorporation of poly fibers in calcium phosphate bone cements substantially improves their strength and toughness while maintaining their ostecompatibility.
Understanding the inner architecture of a nanomedicine29 April 2019
The group of Roland Brock, theme Nanomedicie, and colleagues, used superresolution microscopy to quantitatively image the structure and composition of peptide – messenger RNA nanoparticles and related this to biological activity. They have published their findings in Nano Letters.
The impact of Transradial Intervention (TRI) on digital hand perfusion29 April 2019
Niels van Royen, theme Vascular damage, and colleagues, investigated the effect of TRI on digital perfusion by laser doppler perfusion imaging. They concluded in Circulation: Cardiovascular Interventions, that TRI is safe.
Lanreotide reduces liver and kidney growth in patients with polycystic liver disease29 April 2019
Joost Drenth, theme Renal disorders, made use of data from an open-label, randomized trial to determine the effects of lanreotide on height-adjusted liver volume and combined height-adjusted liver and kidney volume in patients with ADPKD. They have published their findings in Gastroenterology.
High school science education program Immunology and Programming23 April 2019
International PhD candidates Joshua Gillard, Dorien Feyaerts and Yessica Rodriguez of the Laboratory of Medical Immunology (LMI), recently developed and implemented an exciting 4-day science challenge to teach vaccinology, immunology, and programming at the Lorenz Lyceum high school in Arnhem.
Interacting non-specific immunological effects of BCG and Tdapf vaccinations5 April 2019
In a randomized trial Mihai Netea and colleagues aim to investigate the non-specific immunological effects of BCG and DTP-containing vaccines on the immune response to unrelated pathogens. They have published their findings in Clinical Infectious Diseases.
Size matters: Miniaturised interaction proteomics with ultra-low input requirements4 April 2019
Cristina Furlan and René Dirks from the groups of Michiel Vermeulen and Hendrik Marks, theme Cancer development and immune defense, teamed up to develop a low-input interaction proteomics platform, called on-chip AP-MS. They published these findings in Nature Communications.
A personal touch of Glenn van Wigcheren4 April 2019
In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t! This week: Glenn van Wigcheren.
Coronary angiography after cardiac arrest without ST-segment elevation2 April 2019
Niels van Royen, theme Vascular damage, found out and published in NEJM, that among patients who had been successfully resuscitated after out-of-hospital cardiac arrest and had no signs of STEMI, a strategy of immediate angiography was not found to be better than a strategy of delayed angiography.