Radboudumc research most lungs recover well after COVID-1926 November 2020
In severe COVID-19 patients the lung tissue recovers well in most cases. This is shown in research by the Radboudumc, published in Clinical Infectious Diseases. Striking conclusion: patients who were referred by the general practitioner recover worse than ICU patients.
Cell spreading is hard work Bioenergetics of stem cell mechanoresponses in Biomaterials12 November 2020
The study of Bioenergetics of stem cell mechanoresponses, published in Biomaterials is carried out in a collaboration between Werner Koopman, theme Metabolic Diseases, and colleagues from the Radboud University and California Institute of Technology.
967K Euro grant to develop organoids enabling new research methods for skin disorders11 November 2020
Ellen van den Bogaard will lead a consortium, financed by Health Holland, to establish a platform in which materials and technologies are developed to stimulate research with so-called skin organoids, small pieces of cultured skin.
Reprogramming of bone marrow myeloid precursor cells in patients with severe coronary artery disease10 November 2020
Exploratory ''first-in-man'' study adds a new dimension to the role of our innate immune system in the development of cardiovascular disease. This study from Niels Riksen and colleagues is published in Elife.
Veni grants for six Radboudumc researchers5 November 2020
The Netherlands Organization for Scientific Research (NWO) has awarded a Veni grant to six young researchers at Radboudumc, Pascal Miesen, Isabella Wagner, Janita Bralten, Jorge Dominguez Andres, Elin Svensson and Else Eising. This funding will enable them to further develop their research.
Ronald de Groot receives royal decoration as Knight in the Order of Oranje-Nassau.4 November 2020
Ronald de Groot receives royal decoration as Knight in the Order of Oranje-Nassau because of his exceptional contribution to pediatrics, in particular pediatric infectious diseases. He has used his influence, position and experience to help the most vulnerable in our society.
Two studies show potential of trained immunity for the treatment of cancer Radboudumc makes Cell twice in one issue29 October 2020
Mihai Netea: "These studies show that stimulating trained immunity can have an important anti-cancer effect. In combination with current immunotherapy with 'checkpoint inhibitors', boosting trained immunity has the potential to significantly improve cancer treatment"
Largest study ever on research integrity Aimed at all researchers in the Netherlands15 October 2020
Radboudumc participates in the National Survey on Research Integrity (NSRI), which is being distributed to nearly 40,000 researchers in the Netherlands starting today. Hereby a gentle reminder to complete the survey!
Making bones is less difficult than was previously thought Ten-year controversy settled with publication in Nature Communications15 October 2020
The way in which bone formation occurs need to be redefined. This was revealed in a publication in Nature Communications by Nico Sommerdijk, theme Reconstructive and Regenerative Medicine, and his colleagues.
TURBO grants for four medical-technical research projects8 October 2020
On Wednesday, October 7th, four TURBO grants were awarded to new technical-medical research proposals. The grants are part of the TURBO program, a collaboration between the University of Twente (TechMed Centre) and the Radboudumc.
Marie Skłodowska-Curie ITN SkinTERM coordinated by Willeke Daamen and Toin van Kuppevelt6 October 2020
The European Union has granted more than 3 million euro to the SkinTERM project “Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration”. SkinTERM is coordinated by Willeke Daamen en Toin van Kuppevelt.
Uterine B cells involved in healthy pregnancy more insight in the development of pregnancy complications30 September 2020
Immune cells in the uterine wall are important for a successful pregnancy. In a publication in Cell Reports, Marilen Benner and colleagues show that B-cells play an important role in this.
Transfer of new anti-hepatitis C drugs across the human placenta9 September 2020
In a recent publication in American Journal of Obstetrics and Gynecology, researchers from the Departments of Pharmacology and Toxicology, Pharmacy, Obstetrics and Gynecology, Gastroenterology and Hepatology, investigated the placental passage of two such drugs for the first time.
Does the COVID-19 cytokine storm exist? Research may have an impact on the chances of success of a specific treatment4 September 2020
Following the measurement of several important cytokines in patients with COVID-19 and various other severe diseases, researchers at Radboud university medical center now show that COVID-19 is not characterized by a cytokine storm.
Effects of pathogenic fungus screened internationally new fungus Candida auris first observed in 20091 September 2020
Mariolina Bruno, Simone Kersten and Mihai Netea, and colleagues have discovered that the human immune system recognizes the fungus well. Their study has been able to pin-point the fungus' Achilles heel for new, effective drugs. This has recently been published in Nature Microbiology.
Tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture26 August 2020
Carl Figdor and colleagues showed in Nature Communications that the tumour microenvironment (TME) forms a major obstacle in effective cancer treatment and for clinical success of immunotherapy.
Interference transitions in case of invasion of breast cancer determined by cell-cell adhesion and 3D matrix confinement25 August 2020
Peter Friedl and colleagues, theme Cancer development and immune defence, published in Nature Cell Biology (NCB) the mechanisms of jamming and unjamming transitions of mammary carcinoma invasion along tossue microtracks.
Universal Tumor DNA BRCA1/2 Testing of Ovarian Cancer Prescreening PARPi Treatment and Genetic Predisposition20 August 2020
Nicoline Hoogerbrugge, Iris Nagtegaal and Marjolijn Lightenberg published that Universal Tumor BRCA1/2 testing in all newly diagnosed ovarian cancer patients is feasible and effective.
Severe oxygen deficiency corona patient seems treatable ZonMw funds follow-up research into drug effectiveness18 August 2020
Frank van de Veerdonk, Mihai Netea and Roger Brüggemann wrote in JAMA Network Open, that Corona patients with severe oxygen deficiency react positively to treatment with icatibant.