Transfer of new anti-hepatitis C drugs across the human placenta9 September 2020
In a recent publication in American Journal of Obstetrics and Gynecology, researchers from the Departments of Pharmacology and Toxicology, Pharmacy, Obstetrics and Gynecology, Gastroenterology and Hepatology, investigated the placental passage of two such drugs for the first time.
Does the COVID-19 cytokine storm exist? Research may have an impact on the chances of success of a specific treatment4 September 2020
Following the measurement of several important cytokines in patients with COVID-19 and various other severe diseases, researchers at Radboud university medical center now show that COVID-19 is not characterized by a cytokine storm.
Effects of pathogenic fungus screened internationally new fungus Candida auris first observed in 20091 September 2020
Mariolina Bruno, Simone Kersten and Mihai Netea, and colleagues have discovered that the human immune system recognizes the fungus well. Their study has been able to pin-point the fungus' Achilles heel for new, effective drugs. This has recently been published in Nature Microbiology.
Tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture26 August 2020
Carl Figdor and colleagues showed in Nature Communications that the tumour microenvironment (TME) forms a major obstacle in effective cancer treatment and for clinical success of immunotherapy.
Interference transitions in case of invasion of breast cancer determined by cell-cell adhesion and 3D matrix confinement25 August 2020
Peter Friedl and colleagues, theme Cancer development and immune defence, published in Nature Cell Biology (NCB) the mechanisms of jamming and unjamming transitions of mammary carcinoma invasion along tossue microtracks.
Universal Tumor DNA BRCA1/2 Testing of Ovarian Cancer Prescreening PARPi Treatment and Genetic Predisposition20 August 2020
Nicoline Hoogerbrugge, Iris Nagtegaal and Marjolijn Lightenberg published that Universal Tumor BRCA1/2 testing in all newly diagnosed ovarian cancer patients is feasible and effective.
Severe oxygen deficiency corona patient seems treatable ZonMw funds follow-up research into drug effectiveness18 August 2020
Frank van de Veerdonk, Mihai Netea and Roger Brüggemann wrote in JAMA Network Open, that Corona patients with severe oxygen deficiency react positively to treatment with icatibant.
Collective invasion induced by autocrine purinergic loop through connexin-43 hemichannels13 August 2020
Peter Friedl, Paul Span and Antoine Khalil show in Journal of Cell Biology that breastcancer cells release purines into the extracellular space via connexin-43 hemichannels to control collective invasion.
TP53 allelic state is critical for diagnostic and prognostic precision in blood cancer12 August 2020
An international study, in which Joop Jansen participated, shows that a double mutaton in TP53 gene deteriotes the prognosis of a rare form of blood cancer. If there is only one mutation or no mutation, then the prognosis is better.
Hypatia fellowship Call is open30 July 2020
The Hypatia fellowship round with the deadline 31 May has been canceled. Therefore, the next available deadline will be 27 September 2020. Radboudumc researchers are invited to scout young potentials to fill the strategic gaps within the research themes imbedded in RIHS and RIMLS.
Mihai Netea and colleagues published two papers back-to-back in The Journal of Clinical Investigation.29 July 2020
These back-to-back articles investigated the effect of BCG vaccination on trained immunity. The first article shows that BCG vaccination inhibits systemic inflammation, depending on gender. The second article demonstrates that the circadian rhythm influences the induction of trained immunity.
Register for pilot peer coaching for RIMLS PhD candidates14 July 2020
Obtaining your PhD can be a difficult task. In a peer coaching group (“intervisie groep”) you can discuss your (non-technical) problems or dilemmas in a structured way with peers. You can now register for the RIMLS pilot with PhD peer coaching groups. Extended deadline 15 August 2020.
Research Integrity Round 16 September 2020 Sex and gender and research integrity: a tale of how and who9 July 2020
Topic of this webinar is sex and gender in (bio)medical research. Speakers are dean Prof. Jan Smit, Prof. Sabine Oertelt–Prigione and Prof. Hanneke Takkenberg (ErasmusMC). All junior and senior researchers are invited to join the discussion. Please register via the website.
Rebecca Halbach receives idea generator grant to fight mosquito transmitted viruses8 July 2020
Rebecca Halbach and Pascal Miesen have investigated in a collaborative project whether the treatment of mosquitoes with antiviral drugs can prevent the transmission of mosquito-transmitted viral diseases.
Invasive fungal infections in influenza and COVID-198 July 2020
The Aspergillus fungus is found in the lungs of many COVID patients. A parallel occurs with influenza patients, who often develop a serious fungal infection. Although such a serious fungal infection seems to occur less frequently in COVID-patients, alertness remains necessary,
The Postdoctoral Networking Tour in artificial intelligence2 July 2020
You are a postdoctoral researcher in the field of artificial intelligence? The Postdoc-NeT-AI offers you the opportunity to participate in one week of on-site visits to leading German universities, research institutes and companies. Apply now to this year's tour until 16 August 2020.
Online conference offers advantages for scientists2 July 2020
Flying around the world for every congress is outdated. Scientists can now choose for a more environmentally conscious option. Published in 'De Volkskrant', Radboudumc researchers Teun Bousema, Estel Collado and Julie Verhoef argue that the online congress can offer serious advantages.
Experts on metabolic diseases still an unknown major problem...1 July 2020
Six Dutch UMCs and a patient association contribute to treating and solving this major, often unknown, problem. Timely detection of metabolic diseases is vital. Therefore, Radboudumc is also part of the consortium “United for Metabolic Diseases”.
Trained immunity: a tool for reducing susceptibility to and the severity of SARS-CoV-2 infection29 June 2020
In a review in Cell Mihai Netea, Frank van de Veerdonk, Reinout van Crevel and Jorge Dominguez Andres propose that induction of trained immunity by whole-microorganism vaccines may represent an important tool for reducing susceptibility to and severity of SARS-CoV-2.
Master Prizes 2018-2019 awarded for best internship reports24 June 2020
Which students have made the best reports of their scientific internship? On 18 June the Radboudumc Master Prizes were awarded, an annual tradition to reward 'remarkably good scientific work by students'. This year's presentation was virtual, given the corona conditions.
Metabolomics Society Early Career Travel Award for Purva Kulkarni18 June 2020
Purva Kulkarni has been awarded the Metabolomics Society Early Career Travel Award to present her work titled - Towards precision diagnostics: Untargeted metabolomics for the diagnosis of inborn errors of metabolism in individual patients.
Molecular scissors play a role in kidney and lung leakage in COVID-19 patients18 June 2020
‘Molecular scissors', play a role in leakage of fluid from blood vessels to lungs and kidneys in COVID-19 patients. The scissors cut the protective sugar layer in the blood vessels. The more serious the disease, the more active the scissors, wrote Johan van der Vlag and colleagues in MedRxiv.
Antihypotensive agent disrupts the immune system in sepsis11 June 2020
Patients who go into shock caused by sepsis are treated with norepinephrine. Researchers from Radboudumc published results in today’s American Journal of Respiratory and Critical Care Medicine revealing that its use is not without drawbacks.
New insight into the effect of hydroxychloroquine undermines its use in corona11 June 2020
Researchers at Radboud university medical center have discovered an as yet unknown effect of hydroxychloroquine. Raphael Duivenvoorden was interviewed in the program Op1 at NPO1 to elaborate on the findings. It seems unlikely that chloroquine has beneficial effect in corona infections.
3 million euro for Marie Curie ITN SkinTERM5 June 2020
The European Union has provisionally awarded a grant of more than 3 million euro to the SkinTERM project “Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration”. SkinTERM is coordinated with Willeke Daamen as coordinator and Toin van Kuppevelt as vice coordinator.