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LoginImprinted genes during early embryonic development
18 February 2019René Dirks, with other members from the lab of Hendrik Marks, theme Cancer development and immune defense, show in a paper in Epigenetics & Chromatin that genomic imprinting (genes expressed from the paternal or maternal allele only) is often lost in cultured embryonic stem cells.
The first Radboud Nanomedicine community networking event
14 February 2019On 7 February 2019 the first Radboud Nanomedicine community networking event took place. The goal of the event was to bring together all those working in the field of nanomedicine at the Radboud University and Radboudumc, irrespective of the theme in which the research is performed.
Research Integrity Round: The ConScience App 15 February 2019
14 February 2019To introduce the new Netherlands Code of Conduct for Research Integrity we invited ‘Het Acteursgenootschap’ to perform ‘The ConScience App’, a theatre piece designed to move the debate on scientific knowledge. All Radboudumc researchers are invited to attend this event.
Gene involved in colorectal cancer also causes breast cancer
14 February 2019Judith Grolleman, Nicoline Hoogerbrugge and Richarda de Voer, theme Tumors of the digestive tract, published in Cancer Cell that mutations in the NTHL1 gene, previously associated with colorectal cancer, also cause breast cancer and other types of cancer.
Endometrial natural killer cells remember previous pregnancy
11 February 2019Dorien Feyaerts, theme Inflammatory diseases, showed that pregnancy induces a memory phenotype on endometrial natural killer cells. However, previous CMV infection is a prerequisite for this memory induction. They published their findings in Cellular and Molecular Immunology.
ZonMw TOP grant to uncover the dormancy of malaria parasites
7 February 2019Richard Bartfai, theme Infectious diseases and global health, and Clemens Kocken (BPRC) received 675,000 euros from ZonMw to uncover the molecular mechanisms underlying dormancy of malaria parasites, a major obstacle to efficient treatment of P. vivax malaria.
Nature Methods paper on GPCR structure determination
5 February 2019The most recent addition to the GPCR database is a web tool to make the design of crystal constructs easier. CMBI Master's student Janne Bibbe was part of this project, and is now co-author of the paper "An online resource for GPCR structure determination and analysis" in Nature Methods.
A new therapeutic option for the treatment of castration-resistant prostate cancer
5 February 2019Jack Schalken and Vicky Luna Velez and colleagues, theme Urological cancers, published in Oncogene about suppression of prostate tumor cell survival by antisense oligonucleotide-mediated inhibition of AR-V7 mRNA synthesis.
Mitochondrial DNA replication factors in mtRNA metabolism
5 February 2019Hans Spelbrink, theme Mitochondrial diseases, published in Nucleic Acids Research, that two factors in mitochondrial DNA replication, namely the mtDNA helicase Twinkle and the mtDNA single-stranded DNA-binding protein mtSSB, play an important role in mitochondrial RNA metabolism.
Research Integrity Round: The ConScience App
31 January 2019To introduce the new Netherlands Code of Conduct for Research Integrity we invited ‘Het Acteursgenootschap’ to perform ‘The ConScience App’, a theatre piece designed to move the debate on scientific knowledge. All Radboudumc researchers are invited to attend this event.
Dekker grant for Siroon Bekkering
28 January 2019Siroon Bekkering, theme Vascular damage, obtained a Dekker grant of the Dutch Heart Foundation. This competitive grant allows Siroon to perform her project 'Trained innate immunity at the level of bone marrow progenitors as driver of atherosclerosis development'. And follow her vlog.
The master regulatory role of the transcription factor p63 in skin disease
24 January 2019PhD candidate Jieqiong Qu from Jo Huiqing Zhou’s group in Molecular Developmental Biology, theme Reconstructive and regenerative medicine, has published a paper in Cell Reports on the master regulatory role of the transcription factor p63 in skin disease.
COPAL reveals remodeling of mitochondrial protein complexes in Barth syndrome
21 January 2019Martijn Huijnen, theme Mitochondrial diseases, and colleagues developed COmplexome Profiling ALignment (COPAL) to systematically asses the effect of Barth syndome on mitochondrial protein complexes. They published their findings in Bioinformatics.
A personal touch of Febrina Meutiawati
20 January 2019In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t! This week: Febrina Meutiawati.
LEO Foundation grant for Ellen van den Bogaard and Patrick Zeeuwen
17 January 2019LEO Foundation ‘Open competition grants’ are given to support the best dermatology research projects worldwide that improve the understanding of the underlying medicinal, biological, chemical, or pharmacological mechanisms of dermatological diseases and their symptoms.
Diversity in Neutrophils Extracellular Traps
11 January 2019Johan van der Vlag, theme Renal disorders, and colleagues, developed a novel method that allows the discrimination of NETs generated through NOX-dependent or NOX-independent pathways. Their findings were published in Annals of the Rheumatic Diseases.
Radboud university medical center treats metastatic liver cancer with holmium microspheres MRI imaging during surgery can improve the outcome
4 January 2019For the first time Radboud university medical center has treated a patient with liver metastases by using holmium radio-embolization. With this technique, radioactive holmium microspheres are injected via a catheter into the liver artery.
Ciliopathies paper in American Journal of Human Genetics
19 December 2018Miriam Schmidts, theme Renal disorders, and colleagues, discovered that recessive DNAH9 loss-of-function mutations cause laterality defects and subtle respiratory ciliary-beating defects. Their exciting findings are published in the American Journal of Human Genetics.
A personal touch of Dimitri Diavatopoulos
13 December 2018In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t! This week: Dimitri Diavatopoulos.
Five RIMLS researchers in top 1 percent by citations
13 December 2018Bas Dutilh, Leo Joosten, Jos van der Meer, Mihai Netea and Henk Stunnenberg made it to this year’s list of highly cited researchers. Researchers in this list are selected for their exceptional research performance and are regarded to have had a major impact on fellow scientists.
