Radboudumc to lead research team into tackling future pandemics NWO funds complexity research on pandemics5 August 2021
The Radboudumc is going to lead a study on how to deal with future pandemics, together with Radboud University and the University of Amsterdam. Rick Quax from the Informatics Institute/IAS is involved in this project.
Differences in the number of de novo mutations between individuals due to small family-specific effects and stochasticity28 July 2021
Christian Gilissen and colleagues investigated whether there is a family-specific contribution to the number of de novo mutations in the DNA of offspring and published the results in the Genome Research.
Christa Sperna Weiland, Erwin van Geenen and Joost Drenth discuss the best strategy to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis28 July 2021
Christa Sperna Weiland, Erwin van Geenen and Joost Drenth, published in Lancet Gastroenterology & Hepatology a systematic review and network meta-analysis to determine the most efficacious prophylaxis strategy to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis.
ZonMw Gender in Research competition awarded to Genderful Research World Consortium27 July 2021
Natalia Valdrighi and Esmeralda Blaney Davidson won the competition to create a plan for the dissemination of the knowledge and skills gained during the Gender in Research workshop amongst their peers, colleagues and institution, financed by ZonMw and CIHR-IGH in Canada.
Young people with colorectal cancer deserve their own treatment27 July 2021
Richarda de Voer and Marjolijn Ligtenberg's study on clinical, pathological, genetic and molecular characteristics of colorectal tumors in adolescents and adults 25 years of age or younger is published in Clinical Gastroenterology and Hepatology.
Nijmegen literally puts Digital Health on the map Flourishing ecosystem gets its own interactive overview22 July 2021
Digital Health is thriving in the Nijmegen region, where it contributes to better care and health and also creates jobs. To bring developers and end users even closer together, The Economic Board and the Radboudumc are introducing the Interactive Digital Health map.
Michiel Vermeulen and Klaas Mulder receive funding from ZonMw for a collaborative project using stem cell-based models15 July 2021
Michiel Vermeulen and Klaas Mulder, theme Cancer development and immune defense, receive funding from ZonMw for a collaborative project to develop a stem cell based model to study early human embryogenesis.
VIDI grants for researchers of Radboud university medical center14 July 2021
Several Radboudumc researchers have been awarded a VIDI grant by the Dutch Organisation for Scientific Research (NWO). They each receive a sum of 800,000 euros, which they will use over the next five years to develop their own innovative line of research and to set up a research group.
Sonlicromanol seems promising for certain cancers Khondrion announces publication in PLOS ONE of new research13 July 2021
Khondrion announces publication in PLOS ONE of new research showing normalisation of prostate cancer stem cell mPGES-1 overexpression and inhibition of cancer spheroid growth by sonlicromanol’s active metabolite.
Newborn screening in sight through the discovery of novel disease biomarkers by new technique8 July 2021
To identify new biomarkers that can be used in the newborn screening protocol, also known as the neonatal heel prick, Karlien Coene and colleagues joined forces with scientists at the Radboud University’s FELIX laser laboratory. They published their findings in The Journal of Clinical Investigation.
Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum in Nature Communcations1 July 2021
Using complexome profiling Felix Evers, Taco Kooij and colleagues unravel the composition of mitochondrial oxidative phosphorylation complexes of asexual and sexual blood-stage malaria parasites, showing abundance differences and a metabolic switch central to gametocyte development and function.
Biomarkers for pyridoxine-dependent epilepsy identified by untargeted metabolomics and infrared ion spectroscopy24 June 2021
Karlien Coene, theme Metabolic Diseases, and colleagues published in the Journal of Clinical Investigation that untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy.
ZonMw Open Competition Grant for Annemiek van Spriel and Piet Gros15 June 2021
Annemiek van Spriel, theme cancer development and immune defense, together with Piet Gros, Dept. of Chemistry, Utrecht University obtained a ZonMw Open Competition Grant to investigate IL-6 receptor structure and signalling in tumor cells.
Human microbiome could shed light on higher morbidity rate in minoritized populations The link between environmental inequities and disease may lie in the gut15 June 2021
A study published in PNAS is the first to explicitly address the gut microbiome as a pathway to understanding how environmental inequities could lead to health disparities.
A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses8 June 2021
Jeroen Creemers and Johannes Textor published in the Journal for ImmunoTherapy of Cancer that a tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery.
Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses2 June 2021
Rosanne van Deuren published her study in Genome Medicine which shows that functionally grouping common and rare genetic variants enables the elucidation IL-1-mediated biological mechanisms, specifically, for IL-1β and IL-6 cytokine responses induced by various stimuli.
European research project raises hopes in fight against rare diseases Solve-RD successfully established an innovative approach to jointly re-analyze genomic and phenotypic data from unsolved rare disease patients1 June 2021
For the first time in Europe hundreds of rare disease experts team up to actively share and jointly analyze existing data from unsolved rare disease patients.
Vaccination with immune cells boosts immune system after stem cell transplantation1 June 2021
Jesper van Eck van der Sluijs and other researchers have developed a method for growing different types of dendritic cells: the cells of the immune system that specialize in processing foreign substances (including tumor proteins) and presenting them to killer cells.
Aggressive periprocedural hydration + rectal NSAID: no reduction in incidence of post-ERCP pancreatitis1 June 2021
Aggressive fluid hydration plus non-steroidal anti-inflammatory drugs versus non-steroidal anti-inflammatory drugs alone for post-endoscopic retrograde cholangiopancreatography pancreatitis (FLUYT): a multicentre, open-label, randomised, controlled trial.