NL
DE
16 December 2019
The Board of NWO Domain Science has awarded in the NWO Open Competition Domain Science, Jenny van der Wijst, theme Renal disorders, an XS grant. The maximum funding is 50.000 euros per project. The XS category emphatically strives to encourage curiosity-driven and bold research involving a relatively quick analysis of a promising idea. As a pilot, applicants are also an assessor in the XS assessment process.
Project: Novel peptide therapeutic to fight kidney stones
Kidney stones affect around 1 in 10 people worldwide. It can be treated, but recurrence rates are high (>30%) resulting in increased risk of chronic kidney disease. An improved, possibly preventive treatment is needed. Our research aims to develop a novel drug to prevent kidney stone formation, based on our body’s calcium regulation. Calcium, obtained from our diet and essential for i.a. bone, can precipitate in our kidneys. This may lead to crystal formation, and ultimately kidney stone development. We propose to stop this process and prevent stone formation by local calcium buffering in the kidney via an original peptide-drug.
Project: Novel peptide therapeutic to fight kidney stones
Kidney stones affect around 1 in 10 people worldwide. It can be treated, but recurrence rates are high (>30%) resulting in increased risk of chronic kidney disease. An improved, possibly preventive treatment is needed. Our research aims to develop a novel drug to prevent kidney stone formation, based on our body’s calcium regulation. Calcium, obtained from our diet and essential for i.a. bone, can precipitate in our kidneys. This may lead to crystal formation, and ultimately kidney stone development. We propose to stop this process and prevent stone formation by local calcium buffering in the kidney via an original peptide-drug.
