About our equipment

Optical imaging offers unique possibilities for in vitro and in vivo imaging applications, especially in the context of molecular imaging.

Applications in PRIME

The MILabs optical imaging module and the IVIS Lumina can be used for the following applications:

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Applications in PRIME

The MILabs optical imaging module and the IVIS Lumina in PRIME can be used for the following applications:

To study the physiological, pathological and molecular processes in real time and longitudinally;
For diagnostics, pharmacokinetics, pharmacodynamics, and drug screening in preclinical studies.

This imaging modules are used in PRIME for:

Tumor imaging with fluorescence imaging
Skin infection models
Wound healing
Malaria infection/immunization
Disease-inducible promoters for inflammation
Rheumatoid arthritis and osteoarthritis models

More information

Sanne van Lith

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IVIS Lumina Caliber

Standard fluorescent filter sets

Filter set	Label	Background Passband (nm)	Excitation Passband (nm)	Emission Passband (nm)	Dyes, Fluorescent proteins, and Quantum dots
1	Green	410-440	445-490	515-575	GFP, EGFP, FITC
2	Red	460-490	500-550	575-650	DsRed, PKH26, Qdot® 605
3	Far-red	580-610	615-665	695-770	Cy5.5, Alexa Fluor, Qdot®705
4	NIR	665-695	705-780	810-885	ICG, Qdot® 800

Optical Imaging unit MILabs

The MILabs OI units can be used for bioluminescence, fluorescence and Cherenkov imaging, and it can even be combined with the MILabs U-SPECT-6/CT at our facility, to do multimodal imaging. Researchers at PRIME use it for a wide variety of applications to answer their research questions, such as ex vivo imaging of luminescent cells seeded in bone disks, in vivo follow-up of tumor growth through luminescence imaging, or in vivo biodistribution of fluorescently labeled compounds.