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Aims

Gosse Adema's research group focuses on the molecular analysis of professional antigen presenting dendritic cells and Myeloid and T-regulatory cells, and their function in the immune system in health and disease, especially in cancer. Major current projects include:

  • analysis of the Siglec/Sialic Acid axis in immunology and cancer;
  • pre-clinical and clinical studies on cancer ablation by Radiotherapy or HIFU to create in situ cancer vaccines to induce systemic immunity;
  •  development of immune-combination therapies aiming to induce anti-tumor immune responses and to reverse the immune suppressive tumor microenvironment, including blockade of the Siglec-Sialic acid axis and HDAC inhibition.

The knowledge gathered in the fundamental immunological studies is translated into clinical immunotherapy studies.


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Research Research groups Molecular immunology

About Molecular immunology

We aim to achieve long-term survival for cancer patients by bridging the medical physics of ablative interventions and immunotherapy to enable individualized cancer care.

Research group leader

prof. dr. Gosse Adema

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