Research group Molecular immunology

Aims

Gosse Adema's research group focuses on the molecular analysis of professional antigen presenting dendritic cells and Myeloid and T-regulatory cells, and their function in the immune system in health and disease, especially in cancer. Major current projects include:

• analysis of the Siglec/Sialic Acid axis in immunology and cancer;
• pre-clinical and clinical studies on cancer ablation by Radiotherapy or HIFU to create in situ cancer vaccines to induce systemic immunity;
•  development of immune-combination therapies aiming to induce anti-tumor immune responses and to reverse the immune suppressive tumor microenvironment, including blockade of the Siglec-Sialic acid axis and HDAC inhibition.

The knowledge gathered in the fundamental immunological studies is translated into clinical immunotherapy studies.

Publications

See the publication list of the research group leader on Web of Science.