Uncovering the molecular mechanisms of kidney diseases, along with developing innovative functional assays to evaluate calcium, magnesium, sodium, and water transport, is crucial for diagnosing and understanding mineral-wasting tubulopathies. We believe patient-specific models will drive future research into disease mechanisms. Personalized drug screening will set a new standard in treating rare diseases by tailoring therapies to individual patient needs.
Cardiovascular complications are the leading cause of death in patients with chronic kidney disease. Our research focus on the role of calciprotein particles in vascular calcification and shows that targeted interventions may help prevent cardiovascular disease in chronic kidney disease. We believe that a deeper understanding of the mechanisms driving vascular calcification is key to developing effective strategies to lower cardiovascular risk in this population.
We will use advanced urine collection and optical sensing technologies developed in collaboration with OnePlanet, capable of detecting urea, creatinine, turbidity, and specific gravity. By the use of Smart Bathroom technology, health data can be collected. This platform will incorporate novel urine metabolites identified through metabolomics and based on this information, diseases can be detected early and possible (dietary) interventions can be made.
Welcome to Research
We aim to study electrolyte disorders by combining patient genetics with cell, organoid, and animal models to explore kidney mineral regulation and its disruption in cardiovascular and kidney disease.
prof. dr. Joost Hoenderop
Programs that are connected to this research group.
