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Achievements

  1. We have developed improved dosing algorithms for rare complement-mediated diseases.
  2. We have enabled lung cancer chemoimmunotherapy in lung cancer patients with renal impairment and implemented this in practice.
  3. We have developed novel biomarkers for lung cancer immunotherapy.
  4. We have designed phase 2 clinical trials for a novel antimalarial drug using academic model-informed drug development.
  5. We have developed and implemented bedside model-informed precision dosing.


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Research Research groups Applied pharmacometrics

About

We develop and apply mathematical models describing clinical pharmacology processes to interpret clinical trial data, perform clinical trial simulations, support drug development decisions, and optimize therapy in the clinic.

Research group leader

dr. Rob ter Heine

Aims

See our most important goals.

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Aims

It is our ambition to:

  • maximize impact of research by making optimal use of preclinical information and longitudinal clinical data through model-based analyses;
  • facilitate use of advanced pharmacometric methodology in clinical care;
  • support other research groups with population pharmacokinetic-pharmacodynamic data analysis and physiologically based mechanistic modeling;
  • be a center of excellence in pharmacometrics and to train the next generation of researchers.


Achievements

See our impact.

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Profile page

See the group leader's profile.

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Internationally we are also known as

Radboud applied pharmacometrics

Our members

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