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Goals

  • To build and integrate advanced imaging and reporter technologies for monitoring cell function in 3D tissues. 
  • To identify molecular mechanisms of cell and tissue organization under homeostatic and pathological conditions, using state-of-the-art 3D model systems.  
  • To interrogate these models by testing clinically relevant mechanisms and targets, using molecular and genetic interference technologies across disease types in vitro and in vivo. 


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Research Research programs 3D biology and disease mechanisms

Our mission

We aim to enhance the fundamental understanding of single-cell function an multicellular integration in health and disease.

Goals

See some of the most important goals for this research program.

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Research groups contributing to this research program

Advanced bioengineering and therapeutics

Jai Prakash's research group develops engineered therapeutics and bioengineered 3D tumor models to target the tumor microenvironment, improve cancer therapies, and accelerate translation of innovative technologies to the clinic.

Biochemistry of integrative systems

Roland Brock's research group focuses on the targeted delivery of nanomedicines including mRNA antisense oligonucleotides and therapeutic proteins making intensive use of microfluidic tissue-on-a-chip systems and microscopy.

Bone biochemistry

Nico Sommerdijk's research group investigates the mechanisms of collagen assembly and mineralization in health and disease, with focus on processes in bone formation and heart valve calcification.

Spokesperson

prof. dr. Alessandra Cambi

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Spokesperson

prof. dr. Peter Friedl

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Spokesperson

prof. dr. Jack Schalken

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