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Goals

  • To study innate immune responses at population level through systems biology integration of deep immunological phenotyping with (epi)genomic, metagenomic, transcriptomic, metabolomic and proteomic information. 
  • To understand the innate immune-based mechanisms that contribute to the pathophysiology of immune-mediated diseases, particularly infections, inflammatory diseases and cancer. 
  • To improve efficacy of vaccines against several microorganisms using trained immunity. 
  • To explore and optimize the use of innate immune mechanisms (e.g. recombinant cytokines, trained immunity nanobiologics) for immunotherapy of cancer, infections and inflammatory diseases. 


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Research Research programs Innate immunity in health and diseases

Our mission

We aim to understand the function and the regulation of the innate immune system in health and disease and to perform research towards development of diagnostic and therapeutic strategies targeting innate immunity.

Goals

See some of the most important goals for this research program.

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Research groups contributing to this research program

Experimental internal medicine

Mihai Netea's research group investigates the regulation of innate immune responses in health and disease, and based on that it designs and tests new approaches of immunotherapy in infections and immune-mediated diseases.

Experimental medical parasitology

Benjamin Mordmüller's research group discusses, develops and uses human challenge models to investigate infection, pathophysiology and transmission of infectious agents with the aim to improve medical interventions.

Genomic technologies for immune-mediated and infectious diseases

Alexander Hoischen's research group focuses on the application of the latest genomic technologies to understand human disease. A particular emphasis is put on the understanding of genetic defects that explain rare disease specifically immune diseases, such as inborn errors of immunity (IEIs).

Spokesperson

prof. dr. Romana Netea-Maier

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Spokesperson

Vinod Kumar Magadi Gopalaiah

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