Research Research programs Innate immunity in health and diseases

Our purpose

We aim to understand the function and the regulation of innate immune system in health and disease, and to perform research towards development of diagnostic and therapeutic strategies targeting innate immunity.


See some of the most important goals for this research program.

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  • To study innate immune responses is at population level, through the integration of deep immunological phenotyping with various layers of omics: genomics, epigenomics, transcriptomics, metabolomics, proteomics. 
  • To understand the innate immune-based mechanisms that contribute to the pathophysiology of diseases (infections, inflammatory diseases, such as atherosclerosis, gout, and cancer).
  • To improve efficacy of vaccines against several microorganisms using trained immunity.
  • To explore optimize the use of innate immune mechanisms (e.g. recombinant cytokines, trained immunity) for immunotherapy of cancer, infections and inflammatory diseases. 

Research groups contributing to this research program


prof. dr. Leo Joosten

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