Technology center Stem cells


Stem cells Expertise and services

Our technology center assists investigators in performing innovative research, ranging from molecules to man. It connects a broad range of research groups that have expertise in different stem cell fields with a focus on human induced Pluripotent Stem Cell (iPSC) technology.

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Stem cells Expertise and services

The Radboudumc Stem Cell Technology Center assists investigators in performing innovative research, ranging from molecules to man. It connects a broad range of research groups that have expertise in different stem cell fields with a focus on human induced Pluripotent Stem Cell (iPSC) technology. This provides a state-of-the-art service to reprogram different cell types into iPSCs that enable the development of an unlimited source of any type of human cell needed for study or therapeutic purposes.

Aims

  • To generate experimentally validated human iPSCs: reprogrammed iPSCs are analysed for their stemness by quantitative reverse transcription and immunocytochemistry, and the characterisation can be extended to genomic integrity and differentiation capacities into the three germ layers.
  • iPSC culture training and consultancy
  • Consultancy of iPSC differentiation methods
  • Consultancy on other stem cell cultures: human haematopoietic stem cells, human epidermal stem cells, human organoids, mouse embryonic stem cells (serum and 2i conditions)
  • Joint expertise in different research fields: cell biology, genomics and epigenomics.
  • Research projects based on collaboration

Areas of expertise

  • Different stem cell fields with a focus on human iPSC technology
    • Dermatology
    • Epigenetics
    • Genetics
    • Haematology
    • Neurobiology
    • Tissue regeneration

Services

  • Lentiviral transduction of human fibroblasts with pluripotency transcription factors to generate iPSCs
  • Episomal nucleofection of several cell types for iPSC generation
  • iPSCs pluripotency analysis by quantitative reverse transcription and immunocytochemistry

How can we help enhance your research?

Silvia Albert PhD
+31 (0)24 366 73 80
Technology center representative

send an email

How can we help enhance your research?

Jo Zhou PhD
+31 (0)24 361 68 50
Technology center representative

send an email

Application of stem cell technology

Human induced Pluripotent Stem Cells (iPSC) can be used to study disease mechanisms.

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Application of stem cell technology

iPSCs can be used to study disease mechanisms. For example, patient-derived iPSCs can be differentiated into cells, tissues and organs that are normally not available from patients, to identify genetic (e.g. at the mRNA level) and cellular defects in patients. They also provide a platform for developing therapeutic approaches, such as drug screening, gene correction and cell-based strategies, for an individual or a large number of patients.
  • Stem Cell Applications
  • Fundamental studies of development
  • Genetic studies of diseases
  • Disease modelling
  • Drug screening
  • Regenerative medicine

Our experts


Research groups Stem cells

Discover some of our research that is related to stem cells.

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