31 January 2018

In PLoS ONE Carlijn Hooijmans and colleagues describe how the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, the most widely used framework to rate the certainty in the evidence and strength of health care recommendations, could be used to rate the certainty in the evidence of preclinical animal studies in the context of therapeutic interventions.

Laboratory animal studies are used in a wide range of human health related research areas, such as basic biomedical research, drug research, experimental surgery and environmental health. The results of these studies can be used to inform decisions regarding clinical research in humans, for example the decision to proceed to clinical trials. If the research question relates to potential harms with no expectation of benefit (e.g., toxicology), studies in experimental animals may provide the only relevant or controlled data and directly inform clinical management decisions. Systematic reviews and meta-analyses are important tools to provide robust and informative evidence summaries of these animal studies. Rating how certain we are about the evidence could provide important information about the translational probability of findings in experimental animal studies to clinical practice and probably improve it. Evidence summaries and certainty in the evidence ratings could also be used (1) to support selection of interventions with best therapeutic potential to be tested in clinical trials, (2) to justify a regulatory decision limiting human exposure (to drug or toxin), or to (3) support decisions on the utility of further animal experiments. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach is the most widely used framework to rate the certainty in the evidence and strength of health care recommendations. Here we present how the GRADE approach could be used to rate the certainty in the evidence of preclinical animal studies in the context of therapeutic interventions. We also discuss the methodological challenges that we identified, and for which further work is needed. Examples are defining the importance of consistency within and across animal species and using GRADE's indirectness domain as a tool to predict translation from animal models to humans.

Carlijn Hooijmans is assistant professor within the theme of Cancer development and immune defense
 
Publication
Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies. Hooijmans CR, de Vries RBM, Ritskes-Hoitinga M, Rovers MM, Leeflang MM, IntHout J, Wever KE, Hooft L, de Beer H, Kuijpers T, Macleod MR, Sena ES, Ter Riet G, Morgan RL, Thayer KA, Rooney AA, Guyatt GH, Schünemann HJ, Langendam MW; GRADE Working Group. PLoS One. 2018 Jan 11;13(1):e0187271.

 
SYstematic Review Center for Laboratory animal Experimentation

Related news items


Lowering cholesterol is not enough to reduce hyperactivity of the immune system

14 June 2019

In Cell Metabolism, Siroon Bekkering, theme Vascular damage, and colleagues, provides a novel potential explanation for the residual cardiovascular risk, related to persistent activation of the immune system in patients with hypercholesterolemia who are treated with statins.

read more

New cause for vaginal yeast infections discovered

13 June 2019

Martin Jaeger, theme Infectious diseases and global health, and colleagues, identified SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis. Their findings were published in Science Translational Medicine.

read more

Internal KWF review procedure 2020

13 June 2019

In agreement with the existing policy the research board and Radboud Center for Oncology have decided to continue with the mandatory internal review procedure for KWF grant applications.

read more

A personal touch of Johan van der Vlag

13 June 2019

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Johan van der Vlag.

read more

Peter van der Kraan new theme leader Inflammatory diseases

13 June 2019

It is our pleasure to introduce Peter van der Kraan from the Dept. of Rheumatology, as the new leader of our theme Inflammatory diseases. As such he will be the successor of Irma Joosten who has done an outstanding job in the last years as theme leader, for which we thank her wholeheartedly.

read more

RIHS PhD candidates visit Philips Healthcare

13 June 2019

On 7 June the RIHS PhD council organized an excursion to Philips Healthcare in Best.

read more