20 March 2018

Jan van Zelst and Ritse Mann showed in European Radiology that using an intelligent MinIP that comprehensively shows and enhances suspicious areas in automated 3D breast ultrasound volumes obtained in women with dense breasts increases reading efficiency without sacrificing sensitivity, thus improving the clinical utility of the technique.

Objectives 
To determine the effect of computer-aided-detection (CAD) software for automated breast ultrasound (ABUS) on reading time (RT) and performance in screening for breast cancer.
 
Material and methods
Unilateral ABUS examinations of 120 women with dense breasts were randomly selected from a multi-institutional archive of cases including 30 malignant (20/30 mammography-occult), 30 benign, and 60 normal cases with histopathological verification or ≥ 2 years of negative follow-up. Eight radiologists read once with (CAD-ABUS) and once without CAD (ABUS) with > 8 weeks between reading sessions. Readers provided a BI-RADS score and a level of suspiciousness (0-100). RT, sensitivity, specificity, PPV and area under the curve (AUC) were compared.
 
Results
Average RT was significantly shorter using CAD-ABUS (133.4 s/case, 95% CI 129.2-137.6) compared with ABUS (158.3 s/case, 95% CI 153.0-163.3) (p < 0.001). Sensitivity was 0.84 for CAD-ABUS (95% CI 0.79-0.89) and ABUS (95% CI 0.78-0.88) (p = 0.90). Three out of eight readers showed significantly higher specificity using CAD. Pooled specificity (0.71, 95% CI 0.68-0.75 vs. 0.67, 95% CI 0.64-0.70, p = 0.08) and PPV (0.50, 95% CI 0.45-0.55 vs. 0.44, 95% CI 0.39-0.49, p = 0.07) were higher in CAD-ABUS vs. ABUS, respectively, albeit not significantly. Pooled AUC for CAD-ABUS was comparable with ABUS (0.82 vs. 0.83, p = 0.53, respectively).
 
Conclusion
CAD software for ABUS may decrease the time needed to screen for breast cancer without compromising the screening performance of radiologists.
 
Key points
• ABUS with CAD software may speed up reading time without compromising radiologists' accuracy.
• CAD software for ABUS might prevent non-detection of malignant breast lesions by radiologists.
• Radiologists reading ABUS with CAD software might improve their specificity without losing sensitivity.

Publication
Dedicated computer-aided detection software for automated 3D breast ultrasound; an efficient tool for the radiologist in supplemental screening of women with dense breasts. van Zelst JCM, Tan T, Clauser P, Domingo A, Dorrius MD, Drieling D, Golatta M, Gras F, de Jong M, Pijnappel R, Rutten MJCM, Karssemeijer N, Mann RM. Eur Radiol. 2018 Feb 7. doi: 10.1007/s00330-017-5280-3.

Ritse Mann (left) and Jan van Zelst (right) are members of the theme Women's cancers.

 

Related news items


Water as a new tool for cardiac screening for chest pain

2 March 2021

Patients with chest pain not caused by a narrowing of the coronary arteries often do not know the cause of their symptoms. Scientists at the Radboudumc have successfully used a new technique to investigate other causes in the coronary arteries of the heart.

read more

Reducing sitting time improves blood flow in the brain and in the legs

2 March 2021

During a regular day, the average person sits for 8-10 hours. These high levels of sitting time seem linked to an increased risk for both cardiovascular and cerebrovascular diseases.

read more

Vulnerable Nijmegen citizens less likely to visit GP physically due to corona

23 February 2021

The COVID-19 pandemic in 2020 in Nijmegen and the surrounding area led to a substantial decrease in GP consultations for patients with chronic physical health problems.

read more

New Physical, Mental, and Cognitive Problems 1-year Post-ICU

18 February 2021

Half of the Intensive Care Unit (ICU) survivors suffer from new physical, mental and/or cognitive problems one year after ICU admission. This is evident from the large-scale MONITOR-IC study led by the Radboudumc.

read more

Less inflammation with a traditional Tanzanian diet than with a Western diet

18 February 2021

Study shows differences between western and traditional diet.

read more

Trained immunity: a tool for reducing susceptibility to and the severity of SARS-CoV-2 infection

17 February 2021

In a review in Cell Mihai Netea, Frank van de Veerdonk, Reinout van Crevel and Jorge Dominguez Andres propose that induction of trained immunity by whole-microorganism vaccines may represent an important tool for reducing susceptibility to and severity of SARS-CoV-2.

read more