27 August 2018

Paulo Urbano and Hans Koenen, theme Inflammatory diseases, recently published an article in the Journal of Allergy and Clinical Immunology (JACI).

Publication in J Allergy Clin Immunol.: link.
Editorial article: link.

The article provides evidence that the anti-inflammatory ubiquitin editing enzyme TNFα induced protein 3 (TNFAIP3), also known as A20, acts as a master switch for the expression of IL-17A in human CD4+ T cells derived from Inflammatory Bowel disease (IBD) patients. Due its relevance in the field a JACI editorial article was also published highlighting Urbano and Koenen’s findings. ArticleTNF-α-induced protein 3 (TNFAIP3)/A20 acts as a master switch in TNF-α blockade-driven IL-17A expression.

Paulo Urbano and Hans Koenen are member of the theme Inflammatory diseases.

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