27 August 2018

Paulo Urbano and Hans Koenen, theme Inflammatory diseases, recently published an article in the Journal of Allergy and Clinical Immunology (JACI).

Publication in J Allergy Clin Immunol.: link.
Editorial article: link.

The article provides evidence that the anti-inflammatory ubiquitin editing enzyme TNFα induced protein 3 (TNFAIP3), also known as A20, acts as a master switch for the expression of IL-17A in human CD4+ T cells derived from Inflammatory Bowel disease (IBD) patients. Due its relevance in the field a JACI editorial article was also published highlighting Urbano and Koenen’s findings. ArticleTNF-α-induced protein 3 (TNFAIP3)/A20 acts as a master switch in TNF-α blockade-driven IL-17A expression.

Paulo Urbano and Hans Koenen are member of the theme Inflammatory diseases.

 

Related news items


Dutch Society of Clinical Chemistry Science & Innovation Award for the team of Hans Jacobs

14 June 2022 The team of Hans Jacobs pioneers on the development of personalized diagnostics to measure minimal residual disease in patients with multiple myeloma. read more

Joyce Aarts and colleagues published in Scientific Reports about the role of TGF-β1 in (experimental) arthritis

30 March 2022 Joyce Aarts, theme Inflammatory diseases, and her colleagues published in Scientific Reports, that local inhibition of TGF-β1 signaling improves Th17/Treg balance but not joint pathology during experimental arthritis. read more

New EU Research project ImmUniverse

27 February 2020 In this project (31 mEURO), RIMLS and RIHS researchers collaborate with 25 European partners on dissecting common disease mechanisms of Ulcerative Colitis and Atopic Dermatitis. read more

Researchers investigate how stem cells affect the immune system

18 February 2020 RIMLS researchers Irma Joosten and Renate van der Molen, participating in an European study into the treatment of brain damage in premature babies. Is it possible to limit or even partly repair the damage with stem cells? They focus primarily on the effect of those stem cells on the immune system. read more

It is raining Horizon 2020 grants for RIMLS researchers

15 August 2019 Horizon 2020 is the biggest EU Research and Innovation programme ever with nearly €80 billion of funding available and running from 2014 to 2020. This summer, no less than 8 proposals for the Radboudumc have been accepted, 4 of them even as a coordinator. read more

Endometrial natural killer cells remember previous pregnancy

11 February 2019 Dorien Feyaerts, theme Inflammatory diseases, showed that pregnancy induces a memory phenotype on endometrial natural killer cells. However, previous CMV infection is a prerequisite for this memory induction. They published their findings in Cellular and Molecular Immunology. read more