Inflammatory diseases About theme

Chronic inflammation is currently among the leading causes of morbidity and mortality in the Western world. Our aim is to translate results from the molecular and population level to the individual patient to improve diagnosis, disease management and treatment of (chronic) inflammatory disorders.

read more

Inflammatory diseases About theme

Inflammation is classically viewed as an acute response to tissue injury and more often than not resolves spontaneously. A well-controlled inflammatory response has several protective roles: it prevents the spread of infectious agents and damage to nearby tissues; it helps to remove damaged tissue and pathogens; and it assists the body’s repair processes. However, cellular stress and malfunction may trigger chronic inflammation, which, rather than benefiting health, contributes to disease and age-related deterioration. Chronic inflammation is currently among the leading causes of morbidity and mortality in the Western world.
 
Our aim is to translate results from the molecular and population level to the individual patient to improve diagnosis, disease management and treatment of (chronic) inflammatory disorders.

Objectives

  • We aim to unravel the (immune)pathogenesis of inflammatory disease processes and the efficacy and side effects of current treatments.
  • We will assess the role of tissue-specific factors in regulating local immunity and inflammation.
  • We will identify druggable genes and develop anti-inflammatory drugs.
  • We will identify biomarkers for personalized therapy and investigate treatment approaches using biomarkers as co-diagnostics.
  • We aim to capture disease severity in validated outcome measures and assess side effects of treatments in real clinical practice.
  • We will perform (pharmaco)genetic and epidemiological studies to identify risk factors associated with disease susceptibility, severity and treatment outcome.

Theme leader

Irma Joosten PhD
full professor

+31 (0)24 361 53 35

send an email

News and agenda

Organisation


Researchers Inflammatory diseases

See the researchers related to this theme.

read more

Answers in Dutch

Information on our research can also be found in Dutch on the Nationale Wetenschapsagenda website. The information here answers questions asked by Dutch citizens.

Nationale Wetenschapsagenda

Research group leaders

Affiliated institutes and centers

Radboud Institute for Health Sciences

Ideally, every procedure in clinical practice and public health should take place based on proof, instead of intuition or 'experience'. Our aim is to improve clinical practice and public health.

read more

Radboud Institute for Molecular Life Sciences

Our main aim is to achieve a greater understanding of the molecular mechanisms of disease. By integrating fundamental and clinical research, we obtain multifaceted knowledge of (patho)physiological processes.

read more

Technology centers

The Radboudumc technology centers are an access point for technological expertise, high-end equipment and biobanks. We can support a wealth of research questions.

read more
  • Go to