Research theme Inflammatory diseases


Inflammatory diseases About theme

Chronic inflammation is currently among the leading causes of morbidity and mortality in the Western world. Our aim is to translate results from the molecular and population level to the individual patient to improve diagnosis, disease management and treatment of (chronic) inflammatory disorders.

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Inflammatory diseases About theme

Inflammation is classically viewed as an acute response to tissue injury and more often than not resolves spontaneously. A well-controlled inflammatory response has several protective roles: it prevents the spread of infectious agents and damage to nearby tissues; it helps to remove damaged tissue and pathogens; and it assists the body’s repair processes. However, cellular stress and malfunction may trigger chronic inflammation, which, rather than benefiting health, contributes to disease and age-related deterioration. Chronic inflammation is currently among the leading causes of morbidity and mortality in the Western world.
 
Our aim is to translate results from the molecular and population level to the individual patient to improve diagnosis, disease management and treatment of (chronic) inflammatory disorders.

Objectives

  • We aim to unravel the (immune)pathogenesis of inflammatory disease processes and the efficacy and side effects of current treatments.
  • We will assess the role of tissue-specific factors in regulating local immunity and inflammation.
  • We will identify druggable genes and develop anti-inflammatory drugs.
  • We will identify biomarkers for personalized therapy and investigate treatment approaches using biomarkers as co-diagnostics.
  • We aim to capture disease severity in validated outcome measures and assess side effects of treatments in real clinical practice.
  • We will perform (pharmaco)genetic and epidemiological studies to identify risk factors associated with disease susceptibility, severity and treatment outcome.

Theme leader

Irma Joosten PhD
+31 (0)24 361 53 35
full professor

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Researchers Inflammatory diseases

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Our research Inflammatory diseases

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Research group leaders


Answers in Dutch

Information on our research can also be found in Dutch on the Nationale Wetenschapsagenda website. The information here answers questions asked by Dutch citizens.

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