27 June 2019

My name is Jeroen Creemers and I am currently working as a clinical PhD candidate in the Computational Immunology group at the Department of Tumor Immunology, theme Cancer development and immune defense.

When you were a kid what did you want to be when you grew up? Can you tell us something about your child years. 

I was born and raised in Nijmegen and was very active as a child: I liked to play outside in nature, did a lot of sports (judo and swimming) and liked music. As a kid I had many future aspirations: I wanted to live in the tropical rain forests as an explorer, but I also wanted to become a doctor (especially in sports medicine) and an architect. I am glad that I ended up in medicine, which has allowed me to combine a fascination for complex patho-/physiological processes with contact with patients.

What was your previous academic training, where did you study and why that study? 

First, I studied Medical Biology at the Faculty of Science of the Radboud University. It was a really interesting bachelor program which provided an excellent overview of fundamental biological principles. In particular the alterations in signal transduction pathways that lead to unrestrained proliferation of cells during carcinogenesis fascinated me. Although interesting, I noticed that I would like to do more than research alone: I wanted to apply knowledge and encounter complex pathophysiological problems in practice. Therefore, I finished the bachelor program and switched to the master program Medicine at the Radboudumc. My preference for oncology remained and because I would like to combine clinical care for patients with research, I started as a PhD candidate at the Department of Tumor Immunology.

The RIMLS motto is: ‘Today’s molecules for tomorrow’s medicine’. What does this mean for you? 

I think that it describes the pursuit of unravelling the molecular and thereby mechanistic basis of disease to find new therapeutic options for patients.

Who is your great example as scientists? And please give a motivation why.

There are so many great scientists, that I cannot pick just one of them! Already in ancient times there were brilliant minds with great ideas (e.g. Hippocrates), but also more recently we have known giants who have transformed academia. Some great examples in my view are Darwin and Wallace with their ideas on evolution, Watson, Crick and Franklin who unravelled the DNA structure and Kaplan, Meier and Cox who contributed to the current analysis and representation of time-to-event data as published in nearly all clinical studies today.
The similarity between these minds might originate from the fact that they were able to ‘think outside of the box’ and show perseverance during times when others were sceptical.

Which research discovery that you have made has made you most proud? 

The topics that I am currently working on, studying the consequences of conventional clinical trial design in immuno-oncology and implementing new mechanism-based methods to improve clinical trial design, make me proud. The clinical trial industry is a multi-billion dollar industry with (sadly) in terms of patient benefit more setbacks than breakthroughs. Being able to contribute to this field and pursuing an improvement for patients with cancer in these (research) settings provides a great motivation.

Given unlimited finance what experiment would you perform?

Given unlimited finance I would dream bigger than a single experiment! In that case, I would like to set up a state-of-the-art clinical research unit focussing on oncology in which clinicians work alongside fundamental biomedical scientists and data scientists to improve cancer care. The primary focus would be on the translational implementation of fundamental biomedical knowledge in patient care and mechanism-based/data-driven optimisation of clinical trials.

What does your working area (desk, office) look like and what does it say about you (or your research)? 

I share an office with several colleagues on the 5th floor facing the Nijmegen city center. My desk is (often) clean and organized in order to focus as optimal as possible and reduce potential distractions.

Nominate a colleague to be in the spotlight and what would you like to ask him or her?

I would like to nominate Shabaz Sultan, a fellow PhD candidate in our group with a totally different background (informatics/computational modelling). What are the prerequisites for an optimal collaboration between clinicians and data/computer scientists to work together productively and what can both fields learn from one another?

What type of person are you, quick insights:

a) Mac or PC?                                : Both have their strengths and weaknesses 
b) Theater or cinema?                 : Cinema
c) Dine out or dine in?                 : Dine out
d) Ferrari or Fiat?                         : Lamborghini
e) Shopaholic or chocoholic?     : Shopaholic
f) Culture or Nature                     : Nature

Related news items


Social media posts on medication use during pregnancy often incorrect

23 August 2019

Dutch social media regularly post about the safety of medicines for pregnant women. Many pregnant women use these posts as a source of information. A new analysis shows, however, that information found on social media about the risk of medication use often does not correspond with guidelines.

read more

Hans van Bokhoven newly elected in Academia Europaea

22 August 2019

The Academia Europaea is a functioning European Academy of Humanities, Letters and Sciences, composed of individual members.

read more

Drug-induced interstitial lung disease in advanced breast cancer patients receiving everolimus

22 August 2019

In Targeted Oncology, Annelieke Willemsen, Carla van Herpen and colleagues, showed that pulmonary function test with diffusion capacity of the lungs for carbon monoxide and serum biomarkers can be of aid to differentiate everolimus-related interstitial lung disease from other respiratory problems.

read more

Publication in PNAS on dissecting EEC syndrome using single-cell RNA-seq

22 August 2019

PhD candidates Eduardo Soares and Quan Xu in Jo Huiqing Zhou’s group in Molecular Developmental Biology, theme Reconstruction and regenerative medicine, have published a paper in PNAS on the disease mechanism of EEC syndrome using single-cell RNA-seq technology and patient-derived iPSCs.

read more

Patient trust and participation in cell biological research

21 August 2019

Alessandra Cambi and Gert Olthuis, discuss key ethical issues inherent in the development and the value of building trust and trustworthiness.

read more

NWO grant for a tissue-generating patch to close diaphragmatic defects

21 August 2019

Willeke Daamen and Toin van Kuppevelt, theme Reconstructive and regenerative medicine, were recently awarded a 690 k€ grant by NWO, domain Applied & Engineering Sciences, for the development of advanced patches for closure of diaphragmatic defects in children with congenital diaphragmatic hernia.

read more