The awarded research projects of Michiel Vermeulen, Jolanda de Vries, Gerty Schreibelt, Martijn Verdoes and colleagues will initiate new research lines and collaborations between various research groups. Amongst other things, these projects will work on improving immune therapies against cancer and the role of genes in ageing processes.
The, in total 12, awarded projects will jointly receive over nine million euros from this first round of the ZonMw Open Competition. This programme aims to create opportunities for outstanding curiosity-driven (groundbreaking) research. The funding enables excellent research groups to renew their research lines that contribute to health research. Another important requirement is that they realize new collaborations between various research groups.
Defining H3K9 methylation regulatory pathways in monocyte and macrophage function in cardiovascular disease
More information about this project will follow soon.
Jolanda de Vries, Gerty Schreibelt and Martijn Verdoes
Optimizing the design of dendritic cell vaccine immunotherapies
In recent years, vaccination has sprouted as an extremely promising new therapeutic strategy to combat cancer. Many clinical trials are based on the vaccination of cancer patients with peptides corresponding to cancer antigens with the aim of raising anti-cancer cytolytic T lymphocytes (CTL) responses. The efficacy of immune vaccines depends on how effective the peptide is cross-presented by dendritic cells (DCs) to activate CTLs. Goal of this project is to optimize the cross-presentation efficiency of cancer-specific MHC-I-binding epitopes by chemical modifications. We propose to unravel the cell-biological basis of cross-presentation of different antigen vaccine modalities by a combination of novel chemical approaches with state-of-the- art cell biology, microscopy and immunology. We envision that this study will lead to a universal strategy for designing optimal peptide-based anti-cancer vaccines. This novel directed approach will lead to a detailed understanding of CTL cross-priming and thereby allow for smart design strategies to optimize anti-cancer vaccination.
More information: link.
Lowlands Science call for projects17 February 2020
Researchers pay attention! Lowlands is looking for research teams to participate in Lowlands Science 2020. It’s a great way to reach a large audience, do unique experiments with and on them, and to have a memorable experience with your colleagues.Read more
Five ZonMw ‘Off Road’ grants for Radboudumc researchers17 February 2020
Benoit Besson, Annemarie Boleij, Jonne Doorduin, Jorik Nonnekes and Sara Roig Merino have each received an ZonMw ‘Off Road’ grant of €100,000. The grants are intended for biomedical health researchers who dare to go off the beaten track in their search for new insights and unexpected breakthroughs.Read more
Dutch Kidney Foundation PhD grant for Johan van der Vlag and Tom Nijenhuis14 February 2020
Johan van der Vlag and Tom Nijenhuis, theme Renal disorders, received this grant for their joint research project “Targeting a novel paracrine signaling pathway between glomerular endothelium and podocytes to treat glomerular injury”.Read more
KNAW Early Career Award for Geert Litjens13 February 2020
Twelve young researchers received the Early Career Award from KNAW on 4 february. One of them is RIHS researcher Geert Litjens. The Award is aimed at researchers in the Netherlands at the start of their career who are capable of developing innovative and original research ideas.Read more
Interactive career day for Postdocs and PhD candidates13 February 2020
45 Postdocs and PhD candidates attended the first Interactive career day organised by Janssen Pharmaceutica, to learn more about career perspectives and R&D activities that on the longer term can lead to ideas and potential future collaboration.Read more