Johannes Textor, theme Cancer development and immune defense, has been awarded a program grant of 1 million US dollars by The Human Frontier Science Program (HFSP), together with his team members Judith Mandl (McGill University, Montreal, Canada) and Daniel Parisi (Buenos Aires institute of Technology, Argentina).
The T cells of the adaptive immune system are constantly on the move, can enter most tissues, and operate inlarge crowds. Millions of densely packed T cells roam the lymphatic organs in search of foreign antigen while activated T cells divide vigorously and flock to tissues where they mount local immune responses to pathogens or cancer cells.
The HFSP project combines expertise in immunology, computational biology, and pedestrian dynamics to shed light how T cell crowds remain motile with such remarkable efficiency in many conditions and what it would take to disrupt their smooth flow
HFSP grants are highly competitive awards intended for basic research at the frontier of human knowledge. They are open to applicants from all nations, and awardees are selected through a rigorous year-long review process. From more than 700 proposals that were initially submitted by scientists based in more than 50 different countries, only the top 4% were funded, and Johannes Textor's propasal was ranked third overall. Johannes Textor was the only scientist from a Dutch instutition to be selected.
Related news items
What does the shingles vaccine teach us about other vaccines? Investigating the role of trained immunity27 January 2022
The vaccine for shingles, a condition that causes itching, pain, and blisters, is 90% effective, even in elderly. This is remarkable, since most vaccines offer less protection in elderly. Radboudumc is investigating why this vaccine works so well and how it might help us to develop better vaccines.read more
Most COVID-19 ICU survivors experience symptoms one year after ICU admission Publication in JAMA25 January 2022
75% of the COVID-19 survivors who were treated in the Intensive Care Unit (ICU) experience physical, mental and/or cognitive problems one-year post ICU. This shows the large-scale MONITOR-IC study led by Radboudumc.read more
Laurens Verscheijden awarded doctorate degree 'cum laude'19 January 2022
Laurens Verscheijden of the Department of Pharmacology and Toxicology, defended his PhD thesis, entitled "Mechanistic models for the prediction of brain drug exposure and response in the paediatric population: A virtual child reaching maturation.read more