29 April 2019

Transradial intervention (TRI) may impair digital perfusion with hand dysfunction as a result. However, the effect of TRI on digital perfusion has never been investigated, including the influence of variations of the collateral arterial network and the effect on hand dysfunction.

Niels van Royen, theme Vascular damage, and colleagues, investigated the effect of TRI on digital perfusion by laser doppler perfusion imaging. They concluded in Circulation: Cardiovascular Interventions, that TRI is safe. Digital perfusion is reduced in both hands during radial access and TR band application but is not associated with future loss of hand function and variations of the arterial hand supply.

Laser Doppler perfusion imaging was performed at baseline, during radial access, TR band application, and at discharge. compared tissue perfusion of the homolateral thumb (access site) with the contralateral thumb (comparator) during radial access as primary outcome. The hand circulation was assessed with angiography. Upper extremity function was evaluated with the validated QuickDASH questionnaire at baseline and follow-up. A significant reduction of tissue perfusion was observed during radial access and TR band application in the homolateral thumb (−32%, −32%, respectively) and contralateral thumb (−34%, −21%, respectively). They detected no perfusion difference between the homolateral and contralateral thumb during radial access (217; interquartile range, 112–364 versus 209; interquartile range, 99–369 arbitrary flux units; P=0.59). Reduced perfusion of the thumb during radial access was not associated with incompleteness of the superficial palmar arch (P=0.13). Digital perfusion improved at discharge, though it remained below baseline levels (homolateral −11% and contralateral −14%). Hand dysfunction at 18 months was not associated with TRI-induced perfusion reduction (P=0.54).

Related news items


Lowering cholesterol is not enough to reduce hyperactivity of the immune system

14 June 2019

In Cell Metabolism, Siroon Bekkering, theme Vascular damage, and colleagues, provides a novel potential explanation for the residual cardiovascular risk, related to persistent activation of the immune system in patients with hypercholesterolemia who are treated with statins.

read more

A warm welcome for the new forces at RIMLS

13 June 2019

RIMLS is now on full strength by welcoming new colleagues. Let us introduce them to you and find out what they can do for you.

read more

New cause for vaginal yeast infections discovered

13 June 2019

Martin Jaeger, theme Infectious diseases and global health, and colleagues, identified SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis. Their findings were published in Science Translational Medicine.

read more

Internal KWF review procedure 2020

13 June 2019

In agreement with the existing policy the research board and Radboud Center for Oncology have decided to continue with the mandatory internal review procedure for KWF grant applications.

read more

A personal touch of Johan van der Vlag

13 June 2019

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Johan van der Vlag.

read more

Peter van der Kraan new theme leader Inflammatory diseases

13 June 2019

It is our pleasure to introduce Peter van der Kraan from the Dept. of Rheumatology, as the new leader of our theme Inflammatory diseases. As such he will be the successor of Irma Joosten who has done an outstanding job in the last years as theme leader, for which we thank her wholeheartedly.

read more