28 January 2019

Siroon Bekkering, theme Vascular damage, obtained a Dekker grant (209k euro) of the Dutch Heart Foundation. This competitive grant allows Siroon to perform her project 'Trained innate immunity at the level of bone marrow progenitors as driver of atherosclerosis development'.

Siroon Bekkering studies how atherosclerosis progresses through the activation of the immune system. Cholesterol and other inflammatory molecules can activate the innate immune system and make it hyperactive (a process called trained immunity). These hyperactive immune cells are found in the circulation of patients with cardiovascular disease. In this project starting in March 2020 (in the research groups of Mihai Netea and Niels Riksen) Siroon will study specific subtypes and progenitors of innate immune cells and dive into the molecular mechanisms of this hyperactivity. 

In 2018 Siroon obtained a Rubicon grant with her project: Young and obese: does inflammation cause the earlier onset of cardiovascular disease? For this project Siroon is now living in Australia and working at the Murdoch Children’s Research Institute, Royal Children’s Hospital, Melbourne, Australia (Department of Internal Medicine).

About her stay in Australia you can follow her vlog, which she has made for NWO.


Related news items

COVID-19 associated coagulopathy - lessons after 1 year

17 May 2021 Jenneke Leentjens, Saskia Middeldorp, and colleagues, published a review on the current knowledge of COVID-19 associated coagulopathy and the role of antithrombotic therapies in the Lancet Haematology. read more

Set7 regulates enhanced cytokine production in trained immunity in vitro

28 April 2020 Postdoc Sam Keating and colleagues from the group of Niels Riksen, theme Vascular damage, revealed Set7 as a key regulator of trained immunity. They have published their findings in Cell Reports.  read more

Catecholamines induce trained immunity in monocytes in vitro and in vivo

10 April 2020 Niels Riksen and colleagues contributed data in Circulation Research, to the understanding of pathways driving inflammatory changes in conditions characterized by high catecholamine levels, and proposed that trained immunity underlies the increased cardiovascular event rate in PHEO patients. read more

Dutch National Postdoc award for Siroon Bekkering

29 November 2019 Siroon Bekkering, theme Vascular damage, will use the prize money (€10,000) for her follow-up research into the memory of the innate immune system of patients with cardiovascular diseases. read more

RIMLS PhD grants awarded to eight RIMLS (j)PI's

12 September 2019 Recently, RIMLS held an internal call for Radboudumc junior researcher (PhD) positions. Congratulations for all the awardees and all the best in conducting the research projects. read more

Lowering cholesterol is not enough to reduce hyperactivity of the immune system

14 June 2019 In Cell Metabolism, Siroon Bekkering, theme Vascular damage, and colleagues, provide a novel potential explanation for the residual cardiovascular risk, related to persistent activation of the immune system in patients with hypercholesterolemia who are treated with statins. read more