17 May 2021

Jenneke Leentjens, Saskia Middeldorp, and colleagues, published a review on the current knowledge of COVID-19 associated coagulopathy and the role of antithrombotic therapies in the Lancet Haematology.

COVID-19 is associated with a high incidence of thrombotic complications, which can be explained by the complex and unique interplay between coronaviruses and endothelial cells, the local and systemic inflammatory response, and the coagulation system. Empirically, often an intensified dose of pharmacological thrombosis prophylaxis is being used in patients admitted to hospital with COVID-19. Several guidelines on this topic have been published, with varying and weak recommendations as a result of the lack of high quality and direct evidence .

In this viewpoint they summarize the pathophysiology of COVID-19 coagulopathy in the clinical context of patients, i.e. those who are ambulant, admitted to hospital (critically ill or non-critically ill), and those post-discharge from hospital. The researchers also review data from emerging randomized controlled trials in the past year of antithrombotic therapy in COVID-19 patients, and they focus on the unique international collaboration in large platform trials that have yielded the first high quality data that guide clinicians to optimize anticoagulant prophylaxis and to treat COVID-associated coagulopathy. The first-ever trial in non-critically ill patients who were admitted to hospital has shown that a therapeutic dose of low-molecular-weight heparin might improve clinical outcomes in this population. In critically ill patients, this same treatment does not improve outcomes and prophylactic dose thromboprophylaxis is recommended. In the upcoming months they expect numerous data from the ongoing antithrombotic COVID-19 studies to guide clinicians at different stages of the disease.

Related news items


Technology saves lives! 1.9 million euros from the Heart Foundation for developing smart watches

17 November 2021

Niels van Royen is proud to be part of this consortium, initiated by Judith Bonnes, to develop a wrist band for early detection of cardiac arrest. Together with Erasmus, Reinier de Graaf and Corsano Health.

read more

Turbo Grants for four medical-technical research projects

19 October 2021

Four TURBO grants were recently awarded to new technical-medical research proposals. The grants are part of the TURBO program, a collaboration between the University of Twente (TechMed Centre) and the Radboudumc.

read more

First volunteers vaccinated with Radboudumc malaria vaccine

20 May 2021

Today a new vaccine against malaria, largely developed in Nijmegen, is being tested for the first time in volunteers at Radboudumc.

read more

Royal decorations for Nicoline Hoogerbrugge, Jolanda de Vries, Koos van der Velden and Jan Buitelaar

28 April 2021

Nicoline Hoogerbrugge, Jolanda de Vries, Koos van der Velden and Jan Buitelaar are appointed by His Majesty as Knight in the Order of the Dutch Lion, a highly prestigious decoration on 26 April 2021.

read more

Trained immunity: a tool for reducing susceptibility to and the severity of SARS-CoV-2 infection

17 February 2021

In a review in Cell Mihai Netea, Frank van de Veerdonk, Reinout van Crevel and Jorge Dominguez Andres propose that induction of trained immunity by whole-microorganism vaccines may represent an important tool for reducing susceptibility to and severity of SARS-CoV-2.

read more

Transfer of new anti-hepatitis C drugs across the human placenta

9 September 2020

In a recent publication in American Journal of Obstetrics and Gynecology, researchers from the Departments of Pharmacology and Toxicology, Pharmacy, Obstetrics and Gynecology, Gastroenterology and Hepatology, investigated the placental passage of two such drugs for the first time.

read more