11 December 2019

Carl Figdor and colleagues, theme Cancer development and immune defense, provide insights into the initiation of T cell responses in the spleen and their consequences for T cell differentiation. They have published their results in Proceedings of the National Academy of Sciences USA.

Mounting an effective immune response relies critically on the coordinated interactions between adaptive and innate compartments. How and where immune cells from these different compartments interact is still poorly understood. They demonstrated that the cross-talk between invariant natural killer T cells (iNKT) and CD8+ T cells in the spleen, essential for initiating productive immune responses, is biphasic and occurs at 2 distinct sites. Codelivery of antigen and adjuvant to antigen-presenting cells results in: 1) initial short-lived interactions (0 to 6 h), between CD8+ T cells, dendritic cells (DCs), and iNKT cells recruited outside the white pulp; 2) followed by long-lasting contacts (12 to 24 h) between iNKT cells, DCs, and CD8+ T cells occurring in a 3-way interaction profile within the white pulp. Both CXCR3 and CCR4 are essential to orchestrate this highly dynamic process and play nonredundant in T cell memory generation. While CXCR3 promotes memory T cells, CCR4 supports short-lived effector cell generation. 

Related news items


Biomarkers found in COVID-19 patients support bradykinin hypothesis

29 May 2020

A study into inflammatory substances in the blood of COVID-19 patients supports the hypothesis that kinins could play a role in the respiratory problems experienced by critically ill COVID-19 patients in IC. This discovery, published at MedRxiv, could lead to the development of new treatments.

read more

Introducing OnePlanet Research Center webinar 5 June, 16:00 hrs.

29 May 2020

OnePlanet Research Center develops digital technologies to create a society in which everyone can live a healthy life and has access to healthy and sustainable food. Radboudumc and Radboud University are amongst the founding partners. Find out what OnePlanet can do for you in this online session.

read more

The impact of sex and gender in the COVID-19 pandemic

29 May 2020

The case study of Sabine Oertelt-Prigione, developed by the European Commission’s H2020 Expert Group to update and expand "Gendered Innovations/Innovation through Gender", examines the impact of sex and gender in the current COVID-19 pandemic.

read more

Terrestrial bacteria can grow on nutrients from space

26 May 2020

Researchers from the Radboudumc describe in an article in Astrobiology that bacteria can survive on an 'extraterrestrial diet', which affected their pathogenic potential.

read more

The new front line: big data podcast

22 May 2020

What role do big data and technology play in the fight against corona? What data can help save lives? How do you ensure that your personal health data is used safely? Among others, Peter-Bram 't Hoen explains.

read more

OARSI Basic Science Award for Peter van der Kraan

22 May 2020

Purpose of this Basic Science Award of the Osteoarthritis Research Society International (OARSI) is to stimulate fundamental research in the field of osteoarthritis. Congratulations Peter.

read more