Testicular adrenal rest tumors (TARTs) mostly occur in patients with congenital adrenal hyperplasie (CAH) one of the most common congenital adrenal diseases.
In recent studies, an overall TART prevalence of 40% (range 14-89%) in classic CAH-patients is found. Reported differences are mainly caused by the method of detection, and the selected patient population. Biochemically, histologically, and molecularly TARTs exhibit particular adrenal characteristics and were therefore thought to originate from aberrant adrenal cells. More recently TART has been found to also exhibit testicular characteristics. This has led to the hypothesis of pluripotent cells as the origin of TART. High concentrations of adrenocorticotropic hormone (ACTH) could cause hyperplasia of these pluripotent cells, as TART appears to be associated with poor hormonal control with concomitant elevated ACTH. Unfortunately, as yet there are no methods to prevent the development of TART, nor are there guidelines to treat patients with TART. Intensified glucocorticoid treatment could improve fertility status in some cases, although studies report contradicting results. TART can also lead to irreversible testicular damage, therefore semen cryopreservation could be offered to patients with TART.
Further research should focus on the etiology and pharmacological treatment to prevent TART development or to treat TART and improve fertility status of patients with TART.
Related news items

Grants for heart and kidney research Two awards to Radboudumc in Open Competition ENW-XS
21 July 2022Two researchers from the Radboudumc receive a grant from the NWO within the Open Competition of the Exact and Natural Sciences. They are Thijs Eijsvogels, who studies the heart, and Pieter Leermakers, who studies the kidneys.
read more
Veni grants for RIMLS researchers
16 December 2021 NWO has awarded 89 promising young scientists Veni funding of up to 280,000 euros. Three of them are from Radboud Institute of Molecular Life Sciences (RIMLS). They can develop their own research ideas over a period of three years. read more.aspx?width=439&height=263&ext=.png&type=BlockColumn1Zoom1)
Vote for the RIMLS Supervisor of the year
7 December 2021This is your chance to vote for your favourite candidate for supervisor of the year! Support and promote your ideal supervisor from the three nominees: Siroon Bekkering, Gerald Verhaegh and Jo Zhou. Please submit your vote the 20th of December 2021 at the latest.
read more
Technology saves lives! 1.9 million euros from the Heart Foundation for developing smart watches
17 November 2021 Niels van Royen is proud to be part of this consortium, initiated by Judith Bonnes, to develop a wrist band for early detection of cardiac arrest. Together with Erasmus, Reinier de Graaf and Corsano Health. read more
Tiny blood vessels, big problems Radboudumc receives grant for international collaboration
3 November 2021 The Radboudumc, together with the University of Cambridge, receives a grant of €1.8M from three collaborating cardiac foundations for international research into the small blood vessels in the brain. This study will be led by Neurologist Frank-Erik de Leeuw and internist Niels Riksen. read more