2 May 2019

Nathan W. Kucko and Sónia de Lacerda Schickert, theme reconstructive and regenerative medicine, and colleagues, recently published a study in ACS Biomaterials Science and Engineering in which they showed that the incorporation of poly (vinyl alcohol) fibers in calcium phosphate bone cements (CPCs) substantially improves their strength and toughness while maintaining their ostecompatibility, which could dramatically increase CPCs clinical applicability to load-bearing sites.

Pubication: link. 

Injectable, self-setting calcium phosphate cements (CPCs) are favorable bone substitutes due to their osteocompatibility. However, due to their brittleness and low toughness, their clinical application is limited to non-load-bearing sites. The incorporation of poly(vinyl alcohol) (PVA) fibers into cementitious materials is a successful strategy in civil engineering for improving the mechanical performance of cements. However, PVA fibers in particular have not yet been applied to reinforce CPCs. 

Therefore, the aim of this study is to investigate the effect of PVA fibers on the mechanical properties of CPCs. Second, the in vitro cytocompatibility of these fibers is studied using cell culture tests. Finally, the in vivo osteocompatibility of PVA fiber-reinforced CPCs is studied after a 6 and 12 week implantation period in the femoral condyle of rabbits. Results reveal that the incorporation of PVA fibers into CPCs is a highly effective strategy to strengthen and toughen CPCs, since the flexural strength and toughness of CPCs increased by more than 3-fold and 435-fold, respectively, upon reinforcement with PVA fibers. In vitro cytocompatibility tests indicate that PVA fibers are cytocompatible, which is furtherconfirmed by the in vivo results that show that PVA fibers do not compromise the excellent osteocompatibility of CPCs.
  • Want to know more about these subjects? Click on the buttons below for more news.


Related news items

A tunable and injectable local drug delivery system for personalized periodontal application

11 May 2020 In Journal of Controlled Release, Fang Yang and colleagues, have designed and formulated a local delivery system by loading the PLGA-drug microspheres into PIC hydrogel. This system exhibited appropriate injectability, long-term structural stability, and no obvious in vivo inflammatory response. read more

Three Vici grants for Radboudumc researchers

20 February 2020 Christian Beckmann, Sander Leeuwenburgh and Annette Schenck each receive a 1.5 million euro Vici research grant from NWO. read more

NWO grant to develop new biomaterials for improved regeneration of bone defects

20 August 2019 Sander Leeuwenburgh, theme Reconstructive and regenerative medicine, and Roland Brock, theme Nanomedicine, were recently awarded with a grant of 581 k€ by NWO, domain Applied & Engineering Sciences, to develop new biomaterials for improved regeneration of bone defects. read more

H2020 Grant for Frank Walboomers and Ronald Bartels

23 May 2019 Frank Walboomers and Ronald Bartels, theme Reconstructive and regenerative medicine, have received a € 500,000 grant for research into graphene biomaterials from the Europan Union Horizon 2020 FET Open programme. read more

Sónia Schickert represents the Netherlands at the XVI Conference of the European Ceramic Society

9 May 2019 Sónia Schickert, theme Reconstructive and regenerative medicine, will represent the Netherlands at the XVI conference of the European Ceramic Society in Torino, Italy. read more

Biomaterials-aided mandibular reconstruction using in vivo bioreactors

22 March 2019 In a collaborative effort, John Jansen en Jeroen van den Beucken, theme Reconstructive and regenerative medicine, have demonstrated in PNAS the feasibility of an in vivo bioreactor-based strategy to generate vascularized bony tissue and its use for mandibular reconstruction. read more