28 January 2020

In Annals of Oncology, the TIRED trial study group including former RIHS PhD candidate Hanneke Poort, Marlies PetersWinette van der Graaf, Ria Nijhuis-van der Sanden and colleagues described the results of a RCT assessing the effects of cognitive behavioral therapy (CBT) or graded exercise therapy (GET) on fatigue in patients with advanced cancer during treatment with palliative intent in nine centers in The Netherlands.
 
Adult patients  (n=134, 57 % female) with locally advanced or metastatic cancer who reported severe fatigue during treatment were randomly assigned to either 12 weeks of CBT or GET, or usual care (1 : 1: 1, computer-generated sequence). Primary outcome was CIS-fatigue severity at 14 weeks. Secondary outcomes included fatigue measured with the European Organisation for Research and Treatment of Cancer-Quality of Life Questionnaire (EORTC-QLQ-C30), quality of life, emotional functioning, physical functioning, and functional impairments at baseline, 14, 18, and 26 weeks. A total of 126 participants completed assessment at 14 weeks. Compared with usual care, CBT significantly reduced fatigue, whereas GET reduced fatigue, however effects were not significant compared with usual care. Moreover CBT improved also the secondary outcomes, while GET did not. No significant improvements in emotional functioning and functional impairments were observed. The TIRED trial study team concluded that a CBT intervention was more effective than usual care for reducing severe fatigue. Following GET, patients reported lower fatigue, but results were not significant, probably due to a smaller sample size and lower adherence than anticipated.

Publication
Cognitive behavioral therapy or graded exercise therapy compared with usual care for severe fatigue in patients with advanced cancer during treatment: a randomized controlled trial.
Poort H, Peters MEWJ, van der Graaf WTA, Nieuwkerk PT, van de Wouw AJ, Nijhuis-van der Sanden MWG, Bleijenberg G, Verhagen CAHHVM, Knoop H.

 
 

Related news items


RIHS Awards Ceremony five winners

19 February 2020

On 18 February the RIHS 'Koek & Zopie' event took place. In front of an audience of more than 125 colleagues, RIHS awardees accepted their awards for the best PhD thesis, the research product with the highest impact on society, the best peer-reviewed publication and the Supervisor of the year 2019.

read more

Preserved specific force in facioscapulohumeral muscular dystrophy

19 February 2020

Remaining muscle fibers in FSHD patients maintain normal muscle strength, even in severely affected muscles

read more

Researchers investigate how stem cells affect the immune system

18 February 2020

RIMLS researchers Irma Joosten and Renate van der Molen, participating in an European study into the treatment of brain damage in premature babies. Is it possible to limit or even partly repair the damage with stem cells? They focus primarily on the effect of those stem cells on the immune system.

read more

Lowlands Science call for projects

17 February 2020

Researchers pay attention! Lowlands is looking for research teams to participate in Lowlands Science 2020. It’s a great way to reach a large audience, do unique experiments with and on them, and to have a memorable experience with your colleagues.

read more

Five ZonMw ‘Off Road’ grants for Radboudumc researchers

17 February 2020

Benoit Besson, Annemarie Boleij, Jonne Doorduin, Jorik Nonnekes and Sara Roig Merino have each received an ZonMw ‘Off Road’ grant of €100,000. The grants are intended for biomedical health researchers who dare to go off the beaten track in their search for new insights and unexpected breakthroughs.

read more

Dutch Kidney Foundation PhD grant for Johan van der Vlag and Tom Nijenhuis

14 February 2020

Johan van der Vlag and Tom Nijenhuis, theme Renal disorders, received this grant for their joint research project “Targeting a novel paracrine signaling pathway between glomerular endothelium and podocytes to treat glomerular injury”.

read more