The Board of NWO Domain Science has awarded in the NWO Open Competition Domain Science, Jenny van der Wijst, theme Renal Disorders, the ENW KLEIN grant of 350,000 Euro. KLEIN grants offer researchers the possibility to realize curiosity-driven, fundamental research and elaborate creative and risky ideas.
The project “Calmodulation of the epithelial calcium channels TRPV5 and TRPV6: Untangle a dual-faced mechanism” is centered on how the calcium binding protein calmodulin conditions the ion channels’ physiology by exploiting our recently obtained structural data of the TRPV5-calmodulin complex. The TRPV5 and TRPV6 channels form a specific category within the large TRP family of ion channels as they are selectively permeable for calcium ions and play important roles in systemic calcium homeostasis. Using a combination of electrophysiology and advanced fluorescence microscopy, we aim to decipher the calcium-dependency of the TRPV5/6-calmodulin interaction and connect this to changes in channel activity, to provide a so-called ‘calmodulation’ model for these calcium-selective TRP channels.
Outcomes of this project will advance our understanding of the molecular machinery controlling calcium homeostasis. Moreover, it may open up studies for other TRP family members, which is highly relevant to move towards the complete comprehension of TRP channel (patho)physiology.
Related news items
New research through grants for Radboudumc researchers14 January 2021
Several researchers at the Radboudumc have received grants to start new studies, including on rare diseases, liver disease and cancer metastases. These are grants from the Dutch Research Council, European Joint Programme on Rare Diseases and the Gastric Liver Disease Foundation.read more
Should we prepare for a corona-related depression wave? Indira Tendolkar and Eric Ruhé talk about their research projects13 January 2021
Since the outbreak of the SARS-CoV-2, many of us have been staying at home in order to limit our social interactions, to keep ourselves and others safe from the virus. Yet, there’s also concern about what social distancing and anxiety generated by media reports are doing to people's mental health.read more
RIMLS online award ceremony proudly presenting the winners13 January 2021
In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony.read more
Cooling vests alleviate perceptual heat strain perceived by COVID-19 nurses11 January 2021
Wearing cooling vests during a COVID-19 shift ensures that nurses experience less heat during their work. The cooling vests offer such effective cooling that they are now part of the standard work clothing for nurses in the COVID nursing departments at Radboudumc.read more
Koen van den Dries received ENW-XS grant from the NWO7 January 2021
Koen van den Dries has received an ENW-XS grant from the NWO for his project titled: Small differences, large impact: how actin variants differentially control cancer cell migration.read more