The JPI-AMR grant ‘Diagnostics and surveillance of antimicrobial resistance: development of tools, technologies and methods for global use’ has been awarded to Quirijn de Mast and Marien de Jonge, theme Infectious diseases and global health, the Charles University Prague and the Kilimanjaro Christian Medical Centre in Moshi, Tanzania. The project entitled: ‘Prevention of antibiotic resistance by TARGEted Treatment of pneumonia in children (TARGET)’ will be coordinated by Marien de Jonge.
Lower respiratory tract infections (LRTI), such as pneumonia, are a leading cause of death especially in children below the age of 5 years. Low and middle-income countries (LMIC) have the highest burden of childhood pneumonia. Most LRTIs are caused by viruses, but differentiating viral from bacterial causes is mostly impossible due to the lack of accurate diagnostics. As a consequence, most cases are treated empirically leading to overuse and misuse of antibiotics, which is an important driver of the global epidemic of antimicrobial resistance. In this project a newly developed diagnostic device, which is based on the entrapment of aerosols from the lower respiratory tract will be used to identify the etiological agent in children with LRTI.
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