3 February 2021

How do people with reduced immunity, especially kidney patients, react to a COVID-19 vaccination? And how can patients with peripheral arterial disease be helped by DNA testing? Two different studies at the Radboudumc will try to find answers to these two questions. These studies are made possible by ZonMw.

COVID-19 vaccination in people with impaired immune system

Researchers Renate van der Molen, theme Inflammatory diseases and Dimitri Diavatopoulos, theme Infectious diseases and global health and Marije Baas and Luuk Hilbrands, both theme Renal disorders are going to collaborate with all the Dutch umc's to study the safety and efficacy of the corona vaccine for people with impaired immune system. ZonMw has made a sum of 3.2 million euros available for this. The study in which the Radboudumc participates, the RECOVAC study (led by UMC Groningen), looks at kidney patients. For them, COVID-19 is extra dangerous and an effective and safe vaccine is of great importance. Vaccine developers' clinical trials have almost never not included patients with severe renal failure and transplant patients. Therefore, two issues are now being investigated. Firstly, the immune system response and the clinical course after vaccination in patients with severe kidney damage (kidney function less than 30 percent), in dialysis patients and in kidney transplant patients. In addition, the long-term efficacy and side effects of the vaccines in a group of dialysis and kidney transplant patients will be investigated.

Better prescription of blood thinners based on DNA research in patients with peripheral arterial vascular disease

Physician-researchers and PhD candidates Loes Willems and Josephine Kranendonk will initiate the GENPAD study together with vascular and transplant surgeon Michiel Warlé, also principal investigator. For the GENPAD study, they have received a grant of 600K euros from ZonMw. The GENPAD study is a study into better prescription of blood thinners on the basis of DNA research in patients with peripheral arterial disease (arteriosclerosis of the legs). Peripheral arterial vascular disease increases the risk of heart attack, stroke and other cardiovascular diseases. To prevent these complications as much as possible, patients are routinely prescribed a blood thinner, the drug Clopidogrel. In patients with certain DNA changes, Clopidogrel works less well. The GENPAD study will see whether patients suffer fewer complications if the treatment with the blood thinner is adapted to the results of the patient's DNA test. Should this treatment lead to better results, the study will also look at whether this method is cost-effective. This will possibly lead to changes in the current guidelines.

 

Related news items


Call Dutch L’Oréal UNESCO for Women in Science fellowships

12 May 2021

The Fondation L’Oréal and UNESCO invite you to nominate eminent women scientists for the 2022 L’Oréal-UNESCO For Women in Science International Awards. Deadline 31 May 2021.

read more

Dried pepper and video games: novel proteins to generate small RNAs

11 May 2021

Joep Joosten and colleagues determined the composition of PIWI protein complexes to provide novel insights into the piRNA pathway of virus-transmitting mosquitoes. They published this recently in Cell reports.

read more

Four NWO Open Competition Grants for Radboud researchers

11 May 2021

Four researchers from Radboud University and Radboudumc receive a NWO Open Competion grant from the NWO Domain Social Sciences and Humanities.

read more

Miniaturized microfluidic platform for automated epigenetic profiling

6 May 2021

Together with Fluidigm, a US-based company focusing on microfluidics, the team of Hendrik Marks publishes in Genome Research the development of a powerful plug and play ChIP-seq platform for minute amount of cells, such as embryonic specimens or small biopsies.

read more

Broken teeth coronastress poses a danger to our teeth

6 May 2021

Teeth grinding and molars on top of each other: stress from corona causes an increase in dental damage. That's what they noticed at the department of dentistry at Radboudumc.

read more

Annual Paper Awards of Research Theme Tumors of the Digestive Tract

4 May 2021

The annual Paper Awards session of the Research Theme Tumors of the Digestive Tract took place at the 22nd of April. The selected candidates prepared wonderful informative movies, that were judged by the public of the RRR and by our patient representatives.

read more