Research news at Radboudumc.
High school science education program Immunology and Programming23 April 2019
International PhD candidates Joshua Gillard, Dorien Feyaerts and Yessica Rodriguez of the Laboratory of Medical Immunology (LMI), recently developed and implemented an exciting 4-day science challenge to teach vaccinology, immunology, and programming at the Lorenz Lyceum high school in Arnhem.
Prophylactic antibiotics reduce hospitalisations and cost in head and neck cancer patients18 April 2019
In European journal of cancer Janneke Ham and colleagues showed that prophylactic antibiotics in locally advanced head and neck cancer patients treated with chemoradiotherapy did not reduce the incidence of (aspiration) pneumonias, but did reduce hospitalisations and tended to be cost-effective.
Nontuberculous mycobacteria and fungal co-infections Bonnie and Clyde?18 April 2019
In The European respiratory journal Jakko van Ingen and Sanne Zweijpfenning showed that 40% of patients diagnosed with nontuberculous mycobacterial pulmonary disease also meet diagnostic criteria for chronic pulmonary aspergillosis.
Dosing anticancer drugs in patients with renal or hepatic impairment11 April 2019
Renal or hepatic impairment is a common comorbidity for patients with cancer either because of the disease itself, toxicity of previous anticancer treatments, or because of other factors affecting organ function, such as increased age.
Judith Prins appointed scientific director of RIHS a.i.5 April 2019
Judith Prins, full professor of Medical Psychology and prominent principal investigator, has been appointed scientific director ad interim (a.i.) of the RIHS as of 1 April. She succeeds Bart Kiemeney after his RIHS directorship of more than seven years.
Interacting non-specific immunological effects of BCG and Tdapf vaccinations5 April 2019
In a randomized trial Mihai Netea and colleagues aim to investigate the non-specific immunological effects of BCG and DTP-containing vaccines on the immune response to unrelated pathogens. They have published their findings in Clinical Infectious Diseases.
Pim Assendelft on NFU report ‘Research and innovation with and for a healthy region’5 April 2019
On 1 April the report ‘Research and innovation with and for a healthy region; think globally, act locally’ was handed by the Federation of University Medical Centers (NFU) to Minister Bruins of Healthcare.
Size matters: Miniaturised interaction proteomics with ultra-low input requirements4 April 2019
Cristina Furlan and René Dirks from the groups of Michiel Vermeulen and Hendrik Marks, theme Cancer development and immune defense, teamed up to develop a low-input interaction proteomics platform, called on-chip AP-MS. They published these findings in Nature Communications.
800k Euro for research project effectiveness ‘Healthy School’4 April 2019
The Dutch government has started the project ‘Gezonde school’ (‘Healthy School’). Schools can achieve this vignette if they devote time and attention to the health and healthy lifestyle of students on the basis of the ‘Healthy school approach’.
Coronary angiography after cardiac arrest without ST-segment elevation2 April 2019
Niels van Royen, theme Vascular damage, found out and published in NEJM, that among patients who had been successfully resuscitated after out-of-hospital cardiac arrest and had no signs of STEMI, a strategy of immediate angiography was not found to be better than a strategy of delayed angiography.
A robot for health data acquisition among older adults1 April 2019
In BMJ Quality & Safety Roel Boumans and colleagues from the department of Geriatrics showed that social robots may effectively and acceptably assist healthcare professionals by interviewing older adults on their perceived health status.
Impulsivity and infectious diseases among female prisoners in Indonesia Knowledge transfer alone not sufficient for controlling infectious diseases28 March 2019
Unprotected sexual contact and intravenous drug use are important routes of infection for infectious diseases such as HIV, hepatitis B and C and syphilis.
Walking ability in Parkinson patients improves with the clever use of self-discovered compensation strategies26 March 2019
Losing the ability to walk normally is a widespread problem for people with Parkinson's disease. However, patients themselves frequently discover innovative compensation strategies to circumvent their walking problems.
Sarah Verhoeff wins audience award Radboud Talks Jury chose neuroscientist as overall winner26 March 2019
The winner of the fifth edition of scientific pitch competition Radboud Talks is Suhas Vijayakumar, PhD candidate at the Faculty of Social Sciences and the Donders Institute. Research physician Sarah Verhoeff, Radboud Institute for Health Sciences, won the audience award.
Biomaterials-aided mandibular reconstruction using in vivo bioreactors22 March 2019
In a collaborative effort, John Jansen en Jeroen van den Beucken, theme Reconstructive and regenerative medicine, have demonstrated in PNAS the feasibility of an in vivo bioreactor-based strategy to generate vascularized bony tissue and its use for mandibular reconstruction.
eHealth Apps Replacing or Complementing Health Care Contacts21 March 2019
In the Journal of Medical Internet Research, Pim Assendelft and colleagues from the University of Applied sciences Arnhem Nijmegen showed that still relatively little is known about the adverse effects of health apps when used to replace or complement contacts with doctors or nurses.
How a gene called G9a regulates the energy supply for stress18 March 2019
In order to survive, all organisms must be able to detect (threatening) changes in their environment and respond to them adequately and quickly. However, such stress responses (e.g., escape from a predator or immune response to an infection) are very energy-consuming.
Importance of prospective studies in pregnant and breastfeeding women living with HIV14 March 2019
In Clinical Infectious Diseases Angela Colbers, Stein Schalkwijk and David Burger give considerations on how to effectively evaluate aspects of clinical pharmacology required for safe and effective treatment to optimize pharmacotherapy during pregnancy and breastfeeding.
Higher prevalence of coronary atherosclerosis among runners versus cyclists14 March 2019
Physical activity and exercise training are effective strategies to reduce the risk for cardiovascular events, but researchers from Radboudumc, UMC Utrecht and Meander MC previously found a higher burden of coronary atherosclerosis among the most active athletes.
Grant to study mitochondrial morphofunction in Parkinson’s disease14 March 2019
Werner Koopman, theme Mitochondrial diseases, received 400,000 euro as a member of the PD-MitoQUANT consortium. The latter is an EU-funded Innovative Medicines Initiative research project that will improve our understanding of Parkinson’s so that better treatments can be developed in the future.