News Research

Miniaturized microfluidic platform for automated epigenetic profiling

Together with Fluidigm, a US-based company focusing on microfluidics, the team of Hendrik Marks publishes in Genome Research the development of a powerful plug and play ChIP-seq platform for minute amount of cells, such as embryonic specimens or small biopsies.

Broken teeth coronastress poses a danger to our teeth

Teeth grinding and molars on top of each other: stress from corona causes an increase in dental damage. That's what they noticed at the department of dentistry at Radboudumc.

Dutch Children's Formulary now also in use abroad Drug database for pediatric dosing available online for German, Austrian and Norwegian physicians

The Kinderformularium, developed in the Netherlands, now also provides pediatricians and pharmacists abroad with a database of drug dosage recommendations specifically aimed at treating children.

Foundation Fighting Blindness Awards 1.4 million dollars for Rob Collin and Carel Hoyng

Two researchers from the Radboudumc have received a prestigious award from the Translational Research Acceleration Program of the Foundation Fighting Blindness USA.

Radboud university medical center appoints thirteen female professors

Their fields of expertise cover the entire (bio-)medical field, ranging from fundamental and translational to clinical research, education and patient care.

Embryonic development and magnesium homeostasis is regulated by Cyclin M2

Gijs Franken and colleagues, theme Renal disorders, published in Scientific Reports that Cyclin M2 (CNNM2) is vital for embryonic development and magnesium homeostasis.

Higher education does not influence how the brain ages

Contrary to popular belief, a new study from the Lifebrain consortium at the University of Oslo finds that higher education does not slow brain aging. Radboudumc and Donders Institute researcher Rogier Kievit is also part of this study.

Medication for the body's malfunctioning energy system in the works

Radboudumc’s spin-off company Khondrion is developing the promising drug sonlicromanol for treating energy metabolism diseases. Founder of the company Jan Smeitink, theme metabolic disorders, explains.

E-learning avoids gastroscopy in patients with stomach complaints

Many patients with stomach complaints who are referred for a gastroscopy actually do not need that unpleasant examination. Thanks to an e-learning module, they become more aware of their complaints and many of them refrain from such an examination.

Royal decorations for Nicoline Hoogerbrugge, Jolanda de Vries, Koos van der Velden and Jan Buitelaar

Nicoline Hoogerbrugge, Jolanda de Vries, Koos van der Velden and Jan Buitelaar are appointed by His Majesty as Knight in the Order of the Dutch Lion, a highly prestigious decoration on 26 April 2021.

Chronic malaria infections produce more and more infectious gametocytes

In a recent article in Nature Communications, researchers from the department of Medical Microbiology uncovered intriguing dynamics in the production of the transmission stages of malaria parasites, gametocytes.

Same shades of gray but different protein compositions

Maaike van Bergen, theme Cancer development and immune defence, and co-workers published in Blood about specific proteome changes in platelets from individuals with certain bleeding disorders.

Clara van Karnebeek receives a European grant for CHARLIE project

Clara van Karnebeek has received a European grant of 1.88 million Euros for the CHARLIE consortium: an international collaboration to use genetic and stem cell technology to develop new treatments for the neurometabolic diseases GA1 and PDE.

Major EU grants for groundbreaking research into transplant organ rejection

Willem Mulder receives ERC Grant of 2,5 million euros

Sleep researcher Martin Dresler new member FENS-Kavli Network of Excellence

Martin Dresler has been appointed member of the prestigious FENS-Kavli Network of excellence. The sleep researcher will be one of the 30 members of the network, of which 15 members are newly selected every 2 years.

Grants for science communication at Radboudumc

Scientists at the Radboudumc have received two KNAW grants, each worth 10,000 euros, for science communication. With the new fund, KNAW underlines importance of making science accessible.

Obesity increases risk of death in uterine cancer PhD defense of Hannah Donkers on 22 April

Research by Hannah Donkers shows that obesity causes a worse survival rate in women with uterine cancer. In addition, it appears that lower socioeconomic class and anemia also contribute.

Taco Kooij appointed as member Works Council

The interim Works Council election of Radboudumc is now closed, the votes are counted and they have announced the results.

Brain region controls pathological aggression but leaves context-appropriate aggresion intact

In recent work published in Current Biology, researchers from Radboudumc and Donders Institute, as well as other international collaborators, showed that in mice, anterior cingulate cortex dials down excessive aggression, but leaves context-appropriate aggression intact.

Lack of evidence for genetic defects in previously implicated gene in patients with male infertility

In a letter to Cell, researchers from the department of Human Genetics at Radboudumc have raised concerns about the claimed role of PIWIL1 D-box region mutations in human male infertility in an earlier publication in the same journal.

Towards the real-time monitoring of patient resilience

Research in the Department of Geriatrics has explored how quantifying a patient’s physical resilience – the ability to resist functional decline and recover physical health following a stressor – can support clinical intuition and decision-making. Results are published in Experimental Gerontology.

Patients who are obese or overweight are at risk for a more severe course of COVID-19

International study shows risk of mortality does not increase

Nico Sommerdijk appointed professor of Bone Biochemistry

New way of diagnostics detects 'undetectable' genetic defects

Research provides guidance for global application

Vici grant for Michiel Vermeulen Reading the epitranscriptome

Michiel Vermeulen, theme Cancer development and immune defense, has been awarded a Vici grant from the Netherlands Organisation for Scientific Research (NWO), one of the largest personal scientific awards in the Netherlands.

2.5 million Euros for cancer research into ovarian cancer and immunotherapy

The Radboudumc receives 2.5 million Euros from the Dutch Cancer Society (KWF) for three studies to ensure oncological progress during COVID-19 period.

COVID-19 regulations for nursing homes have varying effects

On May 11th 2020, the Dutch Government allowed 26 nursing homes to welcome one visitor per resident, after two months of lockdown. An in-depth Radboudumc study monitored the feasibility of the regulations and the impact on the well-being of residents, their visitors, and healthcare staff.

Anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity

Cell reports publication by Charles Dinarello and Mihai Netea and colleagues, theme Infectious diseases and global health, shows that the anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity.

ADHD-related alterations in brain organization based on different brain profiles

Structural differences between the brains of people with and without ADHD are extensively reported. In accordance with earlier (ENIGMA) studies, and using a large cohort, a newly published study builds upon these by showing differences in brain organization that is based on different brain profiles.

Cross communication between nephron segments by extracellular vesicles

In the FASEB Journal, Joost Hoenderop and other researchers, theme Renal disorders, demonstrated that purinergic signaling and αENaC mRNA expression is controlled by extracellular vesicles flowing along the nephron segments.

Seven million cases of Parkinson's disease The fastest growing brain disease in the world

Over seven million people worldwide have Parkinson's disease, and it is the fastest growing brain disease in the world. Different forms of personalized treatment plans are needed. This is what Radboudumc neurologist Bas Bloem writes in a review article published in The Lancet.

Autoantibody profiles in systemic sclerosis a comparison of diagnostic tests

The research of Ruben Smeets and colleagues in Autoimmunity showed high concordance of prevalent SSc-specific autoantibodies between different diagnostic assays. Further standardisation for low prevalent SSc-specific and SSc-associated autoantibodies is needed.

Academic Alliance Fund (AAF) grant for Florian Krause

He received 100 kEuro for their project “Getting Trauma Under Control: Learning to Self-Regulate PTSD Brain Networks Through Prospective Neurofeedback Training".

Jan Bollen wins the Gauke Kootstra Award

Jan Bollen received the Gauke Kootstra Award, during the annual Boat Congress of the Dutch Transplant Association. Jan Bollen is a final-year resident of the department of anesthesiology at the Radboudumc, but also completed several law studies.

Millions of euros for study of laser treatment for glioblastoma

A research group from Radboudumc and UMC Utrecht is to investigate laser treatment of a rare brain tumor, glioblastoma. 3.9 million euros has been made available for the research by Zorginstituut Nederland and ZonMw, under the auspices of the Subsidy Scheme for Promising Care.

Research on treatment for therapy-resistant obsessive-compulsive disorder

The Radboudumc is participating in a study, led by Amsterdam UMC, into a new, promising treatment for therapy-resistant obsessive-compulsive disorder. A sum of 2.8 million euros has been made available, with several other hospitals and mental healthcare institutions also participating.

RIMLS PhD retreat. Save the date(s)! 8 & 9 July or 14 & 15 Oct 2021

How much are we all longing for an old-fashioned RIMLS PhD retreat full of science, workshops and fun! In normal years, the RIMLS 2-day PhD retreat is held in April. This year, however, it is not yet definitive. Final decision will follow in May.

Promising aftercare for vulnerable patients in ICU

ICU researchers Mark van den Boogaard and Marieke Zegers will receive a ZonMw/ZIN grant of 1.6 million euros for their research into cost-effectiveness of multidisciplinary, structured and personalized post-ICU care.

One drop of blood brings progression of multiple myeloma into better view

Sensitive test opens door to personalized therapy

Rare and complex urology: Clinical overview of ERN eUROGEN

Wout Feitz and colleagues, theme Reconstructive & Regenerative Medicine, Department of Urology, Division of Pediatric Urology (Radboudumc Amalia Children’s Hospital) publish an article in European Urology which well indicates the impact of ERN developments.

Immunomodulatory aged neutrophils are augmented in blood and skin of psoriasis patients

A new study by Radboudumc researchers show that Psoriatic patients have a unique neutrophil profile in circulation, and two distinct neutrophils subsets are present in psoriatic skin. The results are published in the Journal of Allergy and Clinical Immunology on the 19th of March. 

Marie Curie Fellowship for Elena Macías Sánchez

Elena Macías Sánchez has been awarded with a MSCA-IF to develop her project in the department of Biochemistry, RIMLS.

High blood pressure variability a potential target for prevention of post-stroke dementia?

Radboudumc researchers investigated whether blood pressure levels and blood pressure variability influence the risk of post-stroke dementia, in an attempt to find a potential target for prevention of post-stroke dementia. Findings are published in Journal of Hypertension.

‘Mind the gap‘ between clinician-based and patient-relevant outcome measures.

Radboudumc researchers evaluated health-related quality of life, depressive symptoms, fatigue, and physical activity in patients with spinocerebellar ataxia. The results of this study, conducted at the Radboudumc Expert Center for Rare and Genetic Movement Disorders, is published in The Cerebellum.

Skin reconstruction: one operation is enough

In patients undergoing skin reconstruction after a burn, a single operation can be enough to replace both the lower and upper skin.

Hidden genetic defects contain real risks for serious diseases Genome test for consanguineous couples makes sense

For the first time researchers from Hebrew University of Jerusalem, Radboudumc, Maastricht UMC+ and international colleagues have gained insight into the "hidden genetic defects" of the general European population.

Intensive writing week - online from Radboud in'to Languages

This course is for early-career researchers, such as PhD candidates and postdocs, who are writing an article or thesis.

Michiel Schreuder appointed Professor of Pediatric Nephrology

Michiel Schreuder appointed full professor of Pediatric Nephrology as of 16 January 2021.

Phase I/II COVID-19 vaccine trial in humans

Benjamin Mordmüller starts this clinical research at Radboudumc with a European Commission-funded ABNCoV2 vaccine research project.

Joining forces with patient communities to drive FAIR data

Nawel van Lin created a new animation, which was presented during the event on Duchenne data sharing to spread awareness of the benefits of FAIR.