Research news at Radboudumc.
Cost-effectiveness of mpMRI in active surveillance of prostate cancer25 June 2019
In European Urology Oncology Sejal Patel and colleagues evaluated the potential cost-effectiveness of including mpMRI in active surveillance for men diagnosed with low-risk prostate cancer in comparison to the standard monitoring program.
The gap in mortality between older and younger CRC patients has been bridged25 June 2019
In European Journal of Cancer, Nelleke Brouwer, Thea Zonneveld-Heil and colleagues showed that differences in postoperative mortality between older and younger patients with stage I-III colorectal cancer decreased. 1-year postoperative RS was almost equal for older and younger patients in 2015-2016.
Surgery to straighten a deviated septum improves quality of life20 June 2019
Patients with a deviated septum breathe more easily after a septoplasty and their quality of life improves. Specialists have long debated its benefits. Machteld van Egmond, Maroeska Rovers, and Niels van Heerbeek have ended the controversy with a publication in The Lancet.
Development of nationwide recommendations to support prenatal counseling in extreme prematurity20 June 2019
In Pediatrics Rosa Geurtzen et al described the development of a nationwide, evidence-based framework for prenatal counseling in extreme prematurity. It contains recommendations and tools for personalization in the domains of organization, decision-making, content, and style of prenatal counseling.
Radboudumc Master Prize for Mark van Goor18 June 2019
Mark van Goor, theme Renal disorders, received the Radboudumc Master Prize for his MSc thesis entitled “High-resolution structure of the renal calcium channel TRPV5 revealed with cryo-EM”, which was based on his internship at the lab of Prof. Yifan Cheng, USA.
Exome sequencing in routine diagnostics: a generic test for 254 patients with primary immunodeficiencies18 June 2019
Exome sequencing may provide a genetic diagnosis in a significant number of patients in a single genetic test. Alexander Hoischen and Mihai Netea, theme Infectious diseases and global health, and colleagues, published their results in Genome Medicine.
Lowering cholesterol is not enough to reduce hyperactivity of the immune system14 June 2019
In Cell Metabolism, Siroon Bekkering, theme Vascular damage, and colleagues, provide a novel potential explanation for the residual cardiovascular risk, related to persistent activation of the immune system in patients with hypercholesterolemia who are treated with statins.
A personal touch of Johan van der Vlag13 June 2019
In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Johan van der Vlag.
Peter van der Kraan new theme leader Inflammatory diseases13 June 2019
It is our pleasure to introduce Peter van der Kraan from the Dept. of Rheumatology, as the new leader of our theme Inflammatory diseases. As such he will be the successor of Irma Joosten who has done an outstanding job in the last years as theme leader, for which we thank her wholeheartedly.
Intake of a reduced dose of pazopanib with food the effect on pharmacokinetics, patient safety and preference13 June 2019
In Clinical Pharmacology & Therapeutics Floor Lubberman and colleagues showed that the intake of 600mg pazopanib with food resulted in a bioequivalent exposure and was preferred over a standard pazopanib dose without food.
Developing malaria gametocytes under attack6 June 2019
In Science Translational Medicine, researchers from the group of Teun Bousema and international colleagues have revealed previously unknown targets of natural human antibody responses that are found on the surfaces of red blood cells infected with malaria parasites.
The XN-30 hematology analyzer for rapid sensitive detection of malaria a diagnostic accuracy study6 June 2019
In BMC Medicine Annelies Post, Berenger Kaboré, Isaie Reuling and colleagues described a new method of malaria detection using whole blood: the XN-30 is a new hematology analyzer which simultaneously provides a complete blood count and quantification of malaria parasitemia, allowing rapid treatment.
Barrett oesophagus6 June 2019
In Nature Reviews Disease Primers Yonne Peters and Ali Al-Kaabi provided a global overview of Barrett oesophagus and outlined key open research questions. This primer covered epidemiology, disease mechanism, diagnose, screening, prevention, management, and quality of life.
Jeroen Hasselaar elected board member European Association for Palliative Care6 June 2019
On 24 May at the congress for palliative care in Berlin, Jeroen Hasselaar has been elected as a board member of the European Association for Palliative Care (EAPC), for the period 2019-2023. Jeroen was nominated on behalf of the Dutch association for palliative care (Palliactief).
Ingenious solution, but what was the problem?29 May 2019
In Value in Health Anouck Kluytmans, Marcia Tummers, Gert Jan van der Wilt and Janneke Grutters found, using a mixed methods approach, that although a recently developed medical technology was deemed ingenious by stakeholders, there was no underlying problem it could solve in its intended context.
Studying the function of liver cancer genes in mini-organs24 May 2019
Michiel Vermeulen, theme Cancer development and immune defense, and colleagues, have developed a human model in which they use organoids, or mini organs, to study the function of specific genes that are mutated in liver cancer. Their results were published in the scientific journal Cell Stem Cell.
Three VIDI grants for RIMLS researchers24 May 2019
Matthijs Jore, Daniele Tauriello and Johannes Textor are each to receive up to 800,000 euros to develop an innovative research theme and to build up their own research group. NWO is awarding the Vidi grant as part of the Innovational Research Incentives Scheme.
Graduate school news Adjusted PhD guidelines23 May 2019
It should be emphasized that the quality, and not the number of chapters, determines the assessment by the manuscript committee. To avoid the wrong emphasis on quantity, it is not recommended to have more than three publishable chapters in the thesis.
Stress among PhD candidates23 May 2019
Do you struggle with too much stress at work or with your PhD project and is there a high workload? Are there problems with your supervisor or a colleague that you cannot resolve? Do you miss a balance between work and private life? Then make an appointment with one of our Radboudumc counselors.
How do we keep new technology affordable to improve the lives of people?16 May 2019
Improving healthcare by means of new technological developments? We need to change the entire approach for evaluating the true impact , says Maroeska Rovers. By bringing together all stakeholders from the beginning, millions of euros can be saved.
Algorithm calculates the presence and aggressiveness of prostate tumors14 May 2019
A computer program that analyzes MRI images can reliably map the presence and even the aggressiveness of a prostate tumor. This is what Radboudumc researchers and international colleagues have published in the scientific journal Investigative Radiology.
Universal tumor BRCA1/2 testing of ovarian cancer13 May 2019
Marjolijn Ligtenberg, Janet Vos and Nicoline Hoogerbrugge, assessed the feasibility of a workflow for universal tumor DNA BRCA1/2 testing of all newly diagnosed OC patients as prescreen for PARPi treatment and cancer predisposition testing. They have published their findings in the JNCI.
Association of gestational weight gain with adverse maternal and infant outcomes13 May 2019
An individual participant meta-analysis published in JAMA showed that pregnancy BMI is related stronger to maternal and infant complications than to gestational weight gain. The PRIDE Study, with coauthors Marleen van Gelder and Nel Roeleveld, was one of the participating cohorts.
A cozy relationship; the enhancer landscape of embryonic stem cells13 May 2019
In Nature Cell Biology, Yaser Atlasi, Wout Megchelenbrink and colleagues from the group of Henk Stunnenberg, theme Cancer development and immune defense, published a combination of experimental and bioinformatic approaches to study enhancer regulation in different states of embryonic stem cells.