Research news at Radboudumc.
Cognitive behavioral therapy effective in MD1 New treatment option for complex disease21 September 2018
Treatment with cognitive behavioral therapy helps patients with myotonic dystrophy type 1 in improving their physical abilities and social participation. This is the result of a survey of more than 250 patients in four European countries.
Successful teamwork between Neurology and Human Genetics leads to identification of two new ataxia genes19 September 2018
Thanks to close cooperation between Bart van de Warrenburg (Neurology) and Erik-Jan Kamsteeg (Humans Genetics) two new genes involved in movement disorders were identified. The genes are relevant for autosomal recessive cerebellar ataxia.
Rectal cancer staging using MRI with endorectal filling19 September 2018
In the British Journal of Radiology Rutger Stijns and colleagues, showed that using MRI with endorectal filling did not lead to an improved rectal cancer staging and that it has the potential to influence the distance to a key anatomical landmark.
Low risk of progression in persistent non-dysplastic Barrett’s esophagus19 September 2018
In Clinical Gastroenterology and Hepatology Peter Siersema and Yonne Peters showed that patients with stable persistence of non-dysplastic Barrett’s esophagus have a low risk of malignant progression and may not benefit from routine endoscopic surveillance.
Maud Graff appointed as professor of Occupational Therapy11 September 2018
Maud Graff has been appointed as professor (by special appointment) of Occupational Therapy at RadboudUMC and Radboud University. The chair – the first in the Netherlands - is financed by the Dutch Occupational Therapy Association ‘Ergotherapie Nederland’.
Muscle fibrosis in the soft palate: delivery of cells, growth factors and anti-fibrotics30 August 2018
Hans Von den Hoff, recently published an article in Advanced Drug Delivery Reviews together with Willeke Daamen and Toin van Kuppevelt, all from the theme Reconstructive and regenerative medicine.
Super-resolution correlative light and electron microscopy: Spotlight on the cells’ ultrastructure!28 August 2018
Researchers from the Dept. of Cell Biology, theme Nanomedicine, and the ‘Microscopy Imaging Center’ (MIC, a Radboudumc Technology Center), recently developed and optimized a pipeline for correlative imaging using super-resolution (SR) microscopy and scanning electron microscopy (SEM).
Microscopic imaging pierces the “black box” of cancer bone metastasis21 August 2018
Peter Friedl, theme Cancer development and immunce defense, and colleagues, have engineered a system allowing microscopic monitoring and imaging of cancer that has spread to the bone in mice so they can better understand and develop treatment for bone metastasis in humans.
Kidney filter injury further elucidated20 August 2018
Tom Nijenhuis, theme Renal disorders, and colleagues elucidated a novel mechanism that links activity of the calcium-conducting ion channel TRPC6 to structural injury of the kidney filter epithelial cell, via the calcium-dependent protease calpain-1.
Poster prize Lars Damen at 10th European Elastin Meeting17 August 2018
At the 10th European Elastin Meeting, Lars Damen, theme Reconstructive and regenerative medicine, received the early-stage researcher award for his poster entitled “Development of tools to study the sulfation pattern of heparan sulfate involved in elastic fiber biology”.
Prinses Beatrix Spierfonds grant for Rick Wansink and Frank Walboomers23 July 2018
Rick Wansink, theme Nanomedicine, and Frank Walboomers, theme Reconstructive and regenerative medicine, have been awarded a 250.000 EUR grant of the Prinses Beatrix Spierfonds towards the study and elucidation of myotonic dystrophy, in a project entitled: Harmful RNA in myotonic dystrophy.
Researchers and industry join forces to unravel and treat autism Public-private project AIMS-2 receives 110 million euros from IMI12 July 2018
In a large public-private project, supported by 110 million euros by the IMI, a large consortium of researchers will search for biomarkers with which people with autism can be divided into clear subgroups.
Biodegradable nanoreactors demonstrate ROS shielding in human-complex-I-deficient fibroblasts9 July 2018
Researchers of the Radboudumc and colleagues have successfully developed enzyme-loaded polymersomal nanoreactors capable of undergoing cellular integration in a controlled fashion and, subsequently, function as synthetic organelles.
Veterinary drug can prevent outbreaks of malaria and Zika in humans5 July 2018
Drugs that protect pets against ticks and fleas can also be used to prevent outbreaks of malaria, Zika and dengue fever in humans. This was the conclusion of an article by scientists from TropIQ Health Sciences, together with English and American colleagues, and published in the journal PNAS.
Pneumococcal DNA predicts course of infection4 July 2018
In Clinical Infectious Diseases, Radboudumc researchers describe several pneumococcal genes predicting whether a patient runs the risk of developing meningitis or dying from the disease. Use of such genetic tests can improve infection diagnostics.
Making choices in healthcare is difficult but citizens will show politics the way22 June 2018
Well-informed citizens are not just aware of the financial necessity of making choices in healthcare, they are also prepared to make these choices. They do so by providing concrete criteria and examples, which serve as guidelines for politicians.
How to measure >70 (phospho-) protein levels via sequencing DNA-tagged antibodies21 June 2018
Jessie van Buggenum and Klaas Mulder, theme Cancer development and immune defense, show in Nature Communications how immuno-detection by sequencing uses antibodies tagged with DNA barcodes and high-throughput sequencing to detect up to 70 phospho-proteins in skin stem cell.
A low cholesterol level is not a good thing21 June 2018
Research shows that low cholesterol can also be harmful. Researchers from Radboudumc and their Australian and American colleagues discovered a new metabolic defect, producing very low cholesterol levels. This causes brain anomalies, developmental delay, epilepsy and typical facial deformities.