Research news at Radboudumc.
Valentine’s day spectacle at the Radboud Research Rounds21 February 2019
This year’s Valentine’s day in the Radboudumc was focused on the RRR of the Tumors of the Digestive Tract. In the biannual Paper Award session the big prize went to Daniel Garza from the Center for Molecular and Biomolecular Informatics, for his paper on “the environmental metabolome”.
Ultrahigh-resolution MRI reveals structural brain differences in serotonin transporter knockout rats after sucrose and cocaine self-administration20 February 2019
In Addiction Biology Peter Karel and Judith Homberg showed that rats lacking the serotonin transporter show increased cocaine, but unaltered sucrose, self-administration.
Standing balance capacity is easily overestimated in well-recovered stroke survivors20 February 2019
In Neurorehabilitation and Neural Repair Jolanda Roelofs and Sander Geurts showed that well-recovered persons in the chronic phase after stroke with clinically no (or only very limited) motor impairment of the affected leg may still show substantial problems with standing balance control.
Imprinted genes during early embryonic development18 February 2019
René Dirks, with other members from the lab of Hendrik Marks, theme Cancer development and immune defense, show in a paper in Epigenetics & Chromatin that genomic imprinting (genes expressed from the paternal or maternal allele only) is often lost in cultured embryonic stem cells.
The first Radboud Nanomedicine community networking event14 February 2019
On 7 February 2019 the first Radboud Nanomedicine community networking event took place. The goal of the event was to bring together all those working in the field of nanomedicine at the Radboud University and Radboudumc, irrespective of the theme in which the research is performed.
Gene involved in colorectal cancer also causes breast cancer14 February 2019
Judith Grolleman, Nicoline Hoogerbrugge and Richarda de Voer, theme Tumors of the digestive tract, published in Cancer Cell that mutations in the NTHL1 gene, previously associated with colorectal cancer, also cause breast cancer and other types of cancer.
Endometrial natural killer cells remember previous pregnancy11 February 2019
Dorien Feyaerts, theme Inflammatory diseases, showed that pregnancy induces a memory phenotype on endometrial natural killer cells. However, previous CMV infection is a prerequisite for this memory induction. They published their findings in Cellular and Molecular Immunology.
ZonMw TOP grant to uncover the dormancy of malaria parasites7 February 2019
Richard Bartfai, theme Infectious diseases and global health, and Clemens Kocken (BPRC) received 675,000 euros from ZonMw to uncover the molecular mechanisms underlying dormancy of malaria parasites, a major obstacle to efficient treatment of P. vivax malaria.
Stress hormone may improve exposure therapy for patients suffering from PTSD7 February 2019
Exposure therapy is effective in about half of the patients with PTSD. This percentage may possibly increase due to the targeted use of cortisol in the right patients. Benno Roozendaal received a TOP subsidy from ZonMw to investigate this.
Determinants for variation in Integrated Head and Neck Cancer7 February 2019
In National Comprehensive Cancer Network Lydia van Overveld and Rosella Hermens described the quality of current integrated head and neck cancer care using evidence-based quality indicators, the variation between Dutch hospitals, and the influence of patient and hospital characteristics.
Poster Award for Florieke Eggermont et al.7 February 2019
At the 7th Dutch conference on Bio-Medical Engineering on 24 and 25 January 2019, the award for best poster presentation was received by Florieke Eggermont, Yvette van der Linden, Loes Derikx, Marianne de Jong, An Snyers, Tom Rozema, Nico Verdonschot and Esther Tanck.
Nature Methods paper on GPCR structure determination5 February 2019
The most recent addition to the GPCR database is a web tool to make the design of crystal constructs easier. CMBI Master's student Janne Bibbe was part of this project, and is now co-author of the paper "An online resource for GPCR structure determination and analysis" in Nature Methods.
KNAW Ammodo Award for Teun Bousema1 February 2019
Each of the laureates of this prestigious award for top researchers in the Netherlands receive a monetary prize of 300,000 euro. The funds can be used to explore new directions in pure scientific research. Bousema is one of the eight laureates of 2019.
How to approach a patient with refractory or recurrent benign esophageal stricture31 January 2019
In Gastroenterology Peter Siersema described the currently used treatment modalities for complex esophageal strictures, based on underlying cause and symptom duration, but also focusing on future treatment perspectives.
Julia van Tol-Geerdink appointed member Dutch Health Council31 January 2019
Julia van Tol-Geerdink is appointed as member of the Dutch Health Council (Gezondheidsraad). She is now member of the permanent committee on Population screening and of the temporary committee on AAA screening (Abdominal Aorta Aneurysm).
€180k for Orthopaedic Research Laboratory31 January 2019
Researchers of the Orthopaedic Research Laboratory of the Radboudumc, together with the LUMC, received a grant of €180k from the Innovatiefonds Zorgverzekeraars for clinical implementation of patient-specific computer models for fracture risk prediction in patients with bone metastases.
Patient has an important role in reducing inappropriate care31 January 2019
A national research program conducted by the university medical centers has shown that it is both feasible and responsible to reduce inappropriate healthcare. Responsible researchers are Simone van Dulmen, Tijn Kool and Eva Verkerk.
A band aid to prevent blindness a solution in the fight against Stargardt disease25 January 2019
You cut your finger? Patch it up with a band aid and let the healing begin. How convenient would it be if this would work in an eye. If you can cure blinding eye diseases with a band aid, or at least slow them down.
The master regulatory role of the transcription factor p63 in skin disease24 January 2019
PhD candidate Jieqiong Qu from Jo Huiqing Zhou’s group in Molecular Developmental Biology, theme Reconstructive and regenerative medicine, has published a paper in Cell Reports on the master regulatory role of the transcription factor p63 in skin disease.
Psychosocial consequences of living kidney donation24 January 2019
In Nephrology Dialysis Transplantation Lieke Wirken described that longer term health-related quality of life of living kidney donors was generally comparable to baseline, but fatigue levels were elevated up to one year after donation.
Doing research with an intellectual disability New guideline for inclusive health research24 January 2019
Patients are increasingly participating in scientific research into their condition. But how do you do that with people with intellectual disabilities? Tessa Frankena figured it out, with the help of two colleagues who have an intellectual disability themselves.
LEO Foundation grant for Ellen van den Bogaard and Patrick Zeeuwen17 January 2019
LEO Foundation ‘Open competition grants’ are given to support the best dermatology research projects worldwide that improve the understanding of the underlying medicinal, biological, chemical, or pharmacological mechanisms of dermatological diseases and their symptoms.
Exergaming as an effective method to engage people with dementia in physical exercise11 January 2019
In Alzheimers Research & Therapy Esther Karssemeijer and Roy Kessels from the departments of Geriatrics and Medical Psychology showed that a 12-week exergame and aerobic training improve psychomotor speed in people with dementia.
Radboudumc fertility treatments have highest success rate in the Netherlands10 January 2019
In 2017 the probability of a successful pregnancy after fertility treatment was greatest at Radboudumc. In that year, Radboudumc had the best outcomes of all fertility clinics in the Netherlands, not only for regular IVF and ICSI treatments, but also for cryogenic treatments.