Research news at Radboudumc.
Two projects granted for experimental Rheumatology22 October 2019
Osteoarthritis is the most prevalent and debilitating joint disease worldwide but no cure has been developed yet. Recent findings show that low grade inflammation within the OA joint contributes to the pathophysiology and clinical symptoms.
Radboud Bioinformatics Xmas event 16 December21 October 2019
The CMBI is organizing the event of the year for all bioinformaticians throughout Radboud University and Radboudumc to give you the opportunity to bring forward the biggest challenges in your research to expert bioinformaticians and pave the way for real solutions.
Merel Ritskes-Hoitinga has been appointed honorary Skou professor at Aarhus University17 October 2019
Merel Ritskes-Hoitinga has been appointed honorary Skou Professor at the Dept. of Clinical Medicine, at Aarhus University. The aim is to introduce new perspectives to teaching, strengthen relations with leading research units abroad and establish joint research projects and funding applications.
KWF Roadshow 11 November 201910 October 2019
In which way(s) can KWF provide optimal support to oncological research and care? How can we maximize impact on our investments? These questions are pivotal in Ambition 2030: the vision that KWF developed in close cooperation with stakeholders in the oncological field.
More than 3000 visitors at Open Day RIHS10 October 2019
On Sunday 6 October RIHS organized an Open Day in the Weekend of Science (“Weekend van de Wetenschap”) with special guest and television presenter Klaas van Kruistum. More than 3000 visitors became a health scientist for one day and discovered how special healthcare research is.
Dorine Swinkels collaborates with winners of the Nobel Prize in Physiology or Medicine9 October 2019
The Nobel Prize in Physiology or Medicine 2019 was awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza for their discoveries of how cells sense and adapt to oxygen availability.
Scaling up nanotherapy7 October 2019
Scaling up and translating nanotherapy from pre-clinical work in small animal models to a clinical application is not trivial. Raphael Duivenvoorden, theme Renal disorders, and colleagues, published their results on translating a new nanoimmunotherapy in the journal Science Translational Medicine.
‘Smart shirt’ can accurately measure breathing and could be used to monitor lung disease3 October 2019
Denise Mannée and colleagues are developing Hexoskin, a smart shirt that can measure breathing in people. It can reliably measure breathing in healthy people while carrying out activities. This means they can now test out the smart shirts with patients who have COPD.
RIMLS 25 years jubilee festival The Future is Yesterday3 October 2019
Together with more than 250 colleagues and alumni we celebrated 25 years of research into the molecular mechanisms of disease. During this exciting and informal event, we not only took a trip down memory lane, but also looked ahead to the next 25 years and beyond…...
A coordinated analysis on the association of sedentary behaviour and cognitive function1 October 2019
In Sports Medicine Carlijn Maasakkers and colleagues present the results from a coordinated analysis in 5 cohorts on the association between total sitting time and global cognition. As no clear associations were found, they hypothesize that specific types of sitting differentially affect cognition.
New mitochondrial DNA maintenance disease uncovered1 October 2019
The group of Hans Spelbrink, theme Mitochondrial diseases, and colleagues, has identified and characterized mutations in the mtDNA maintenance gene SSBP1 in families with optic atrophy and foveopathy. This paper is now online in The Journal of Clinical Investigation.
Charity event for children with a diaphragmatic defect26 September 2019
For the third year in a row, Rotary Ridderkerk - de Waal organised a golf tournament, dinner and auction to raise research funds for children with congenital diaphragmatic hernia. At the end of the day, a cheque worth € 51,000 was handed over to Sanne Botden and Willeke Daamen.
Digital health updates Stay up to date with a podcast26 September 2019
As a researcher it is important to know the ins and outs of your research area. Despite helpful tools and filters this is often very time consuming. The Lancet Digital Health offers podcasts in which authors present the key findings and implications of their work.
The effect of an invasive approach on final infarct size and clinical outcome up to 1 year24 September 2019
Niels van Royen published in JACC: Cardiovascular Interventions, that patients with transient STEMI have limited infarction and well-preserved myocardial function in general, and delayed or immediate revascularization has no effect on functional outcome and clinical events up to 1 year.
Radboud-led collaboration generates innovative candidate drug against malaria19 September 2019
A molecule once designed to cure the skin disease psoriasis appears to be particularly effective against malaria. The antimalarial properties were revealed thanks to one researcher’s inspired hunch when the psoriasis drug discovery programme came to a dead end.
Radboud university medical center opens first healthcare AI labs19 September 2019
These are the first two ‘labs’ in the east of the Netherlands that are part of the national Innovation Center for Artificial Intelligence and the first health labs. With these two initiatives, Radboudumc and its partners are investing heavily in the application of AI to health care.
Careful prescription of addictive painkillers still necessary19 September 2019
Although the use of opioid painkillers in the Netherlands has risen over the past ten years, it is nowhere near the degree to which they are used in the United States, say Arnt Schellekens and his colleagues in an article published in The Lancet Public Health.
Radboud study on Dirty Money wins Ig Nobel Prize17 September 2019
By shaking hands we are exchanging bacteria. Does this happen without direct hand-to-hand contact, for example when paying with paper money? Andreas Voss, clinical microbiologist at Radboudumc and CWZ, and colleagues in the United States received an Ig Nobel Prize for research into dirty money.
Artificial intelligence for renal tissue assessment16 September 2019
Meyke Hermsen and Jeroen van der Laak, present an alternative approach, featuring a convolutional neural network for multi-class segmentation of periodic acid–Schiff-stained kidney tissue sections. Their work was published in the Journal of the American Society of Nephrology.
Phantomless calibration of CT scans for fracture risk assessment in cancer patients with femoral bone metastases5 September 2019
In Plos One, Florieke Eggermont, Esther Tanck and colleagues developed a calibration method, which makes clinical implementation of CT-based finite element models as tool for fracture risk assessment easier.
New technique boosts preclinical antibody research30 August 2019
Martijn Verdoes, theme Nanomedicine, and Bas van der Schoot, theme Cancer development and immune defense, developed a technique to engineer and produce antibodies quickly, easily and cheaply. The researchers published their results in the open access journal Science Advances.
Help us evaluate the improved design of the lab U-workspace in practice29 August 2019
We have built two examples of the redesigned lab U-workspaces in the Research Tower (M850) on the 6th and 7th floor. These so-called ‘mockups’ are experimental setups that enable all potential users to evaluate the re-design of the workspaces in practice.
Publication in Blood on CD37 mutations in lymphoma26 August 2019
Suraya Elfrink, in Annemiek van Spriel's research group Immune cell signaling, theme Cancer development and immune defense, published a manuscript in Blood reporting that tetraspanin CD37 is frequently mutated in patients with diffuse large B cell lymphoma occurring at immune-privileged sites.
More than 350 festival attendees learned CPR during the Lowlands Saves Lives trial26 August 2019
During the 2019 Lowlands music festival, the Lowlands Saves Lives trial was performed by the department of Cardiology. The study was a huge success as over 350 participants were randomized and learned to perform CPR.
University Teaching Prize for Joost Hoenderop26 August 2019
The prize is a reward for excellent teaching and consists of a certificate and a sum of €3000, two-thirds of which is to be spent on educational activities. The prize was awarded on Monday 2 September when the 2019-2020 Academic Year was opened.
Social media posts on medication use during pregnancy often incorrect23 August 2019
Dutch social media regularly post about the safety of medicines for pregnant women. Many pregnant women use these posts as a source of information. A new analysis shows, however, that information found on social media about the risk of medication use often does not correspond with guidelines.
Drug-induced interstitial lung disease in advanced breast cancer patients receiving everolimus22 August 2019
In Targeted Oncology, Annelieke Willemsen, Carla van Herpen and colleagues, showed that pulmonary function test with diffusion capacity of the lungs for carbon monoxide and serum biomarkers can be of aid to differentiate everolimus-related interstitial lung disease from other respiratory problems.
Publication in PNAS on dissecting EEC syndrome using single-cell RNA-seq22 August 2019
PhD candidates Eduardo Soares and Quan Xu in Jo Huiqing Zhou’s group in Molecular Developmental Biology, theme Reconstruction and regenerative medicine, have published a paper in PNAS on the disease mechanism of EEC syndrome using single-cell RNA-seq technology and patient-derived iPSCs.
NWO grant for a tissue-generating patch to close diaphragmatic defects21 August 2019
Willeke Daamen and Toin van Kuppevelt, theme Reconstructive and regenerative medicine, were recently awarded a 690 k€ grant by NWO, domain Applied & Engineering Sciences, for the development of advanced patches for closure of diaphragmatic defects in children with congenital diaphragmatic hernia.