Research news at Radboudumc.
Miniaturized microfluidic platform for automated epigenetic profiling6 May 2021
Together with Fluidigm, a US-based company focusing on microfluidics, the team of Hendrik Marks publishes in Genome Research the development of a powerful plug and play ChIP-seq platform for minute amount of cells, such as embryonic specimens or small biopsies.
Dutch Children's Formulary now also in use abroad Drug database for pediatric dosing available online for German, Austrian and Norwegian physicians30 April 2021
The Kinderformularium, developed in the Netherlands, now also provides pediatricians and pharmacists abroad with a database of drug dosage recommendations specifically aimed at treating children.
Higher education does not influence how the brain ages28 April 2021
Contrary to popular belief, a new study from the Lifebrain consortium at the University of Oslo finds that higher education does not slow brain aging. Radboudumc and Donders Institute researcher Rogier Kievit is also part of this study.
E-learning avoids gastroscopy in patients with stomach complaints28 April 2021
Many patients with stomach complaints who are referred for a gastroscopy actually do not need that unpleasant examination. Thanks to an e-learning module, they become more aware of their complaints and many of them refrain from such an examination.
Royal decorations for Nicoline Hoogerbrugge, Jolanda de Vries, Koos van der Velden and Jan Buitelaar28 April 2021
Nicoline Hoogerbrugge, Jolanda de Vries, Koos van der Velden and Jan Buitelaar are appointed by His Majesty as Knight in the Order of the Dutch Lion, a highly prestigious decoration on 26 April 2021.
Clara van Karnebeek receives a European grant for CHARLIE project28 April 2021
Clara van Karnebeek has received a European grant of 1.88 million Euros for the CHARLIE consortium: an international collaboration to use genetic and stem cell technology to develop new treatments for the neurometabolic diseases GA1 and PDE.
Sleep researcher Martin Dresler new member FENS-Kavli Network of Excellence22 April 2021
Martin Dresler has been appointed member of the prestigious FENS-Kavli Network of excellence. The sleep researcher will be one of the 30 members of the network, of which 15 members are newly selected every 2 years.
Brain region controls pathological aggression but leaves context-appropriate aggresion intact21 April 2021
In recent work published in Current Biology, researchers from Radboudumc and Donders Institute, as well as other international collaborators, showed that in mice, anterior cingulate cortex dials down excessive aggression, but leaves context-appropriate aggression intact.
Lack of evidence for genetic defects in previously implicated gene in patients with male infertility20 April 2021
In a letter to Cell, researchers from the department of Human Genetics at Radboudumc have raised concerns about the claimed role of PIWIL1 D-box region mutations in human male infertility in an earlier publication in the same journal.
Towards the real-time monitoring of patient resilience20 April 2021
Research in the Department of Geriatrics has explored how quantifying a patient’s physical resilience – the ability to resist functional decline and recover physical health following a stressor – can support clinical intuition and decision-making. Results are published in Experimental Gerontology.
Vici grant for Michiel Vermeulen Reading the epitranscriptome15 April 2021
Michiel Vermeulen, theme Cancer development and immune defense, has been awarded a Vici grant from the Netherlands Organisation for Scientific Research (NWO), one of the largest personal scientific awards in the Netherlands.
COVID-19 regulations for nursing homes have varying effects14 April 2021
On May 11th 2020, the Dutch Government allowed 26 nursing homes to welcome one visitor per resident, after two months of lockdown. An in-depth Radboudumc study monitored the feasibility of the regulations and the impact on the well-being of residents, their visitors, and healthcare staff.
Anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity14 April 2021
Cell reports publication by Charles Dinarello and Mihai Netea and colleagues, theme Infectious diseases and global health, shows that the anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity.
ADHD-related alterations in brain organization based on different brain profiles14 April 2021
Structural differences between the brains of people with and without ADHD are extensively reported. In accordance with earlier (ENIGMA) studies, and using a large cohort, a newly published study builds upon these by showing differences in brain organization that is based on different brain profiles.
Cross communication between nephron segments by extracellular vesicles13 April 2021
In the FASEB Journal, Joost Hoenderop and other researchers, theme Renal disorders, demonstrated that purinergic signaling and αENaC mRNA expression is controlled by extracellular vesicles flowing along the nephron segments.
Seven million cases of Parkinson's disease The fastest growing brain disease in the world13 April 2021
Over seven million people worldwide have Parkinson's disease, and it is the fastest growing brain disease in the world. Different forms of personalized treatment plans are needed. This is what Radboudumc neurologist Bas Bloem writes in a review article published in The Lancet.
Autoantibody profiles in systemic sclerosis a comparison of diagnostic tests8 April 2021
The research of Ruben Smeets and colleagues in Autoimmunity showed high concordance of prevalent SSc-specific autoantibodies between different diagnostic assays. Further standardisation for low prevalent SSc-specific and SSc-associated autoantibodies is needed.
Millions of euros for study of laser treatment for glioblastoma2 April 2021
A research group from Radboudumc and UMC Utrecht is to investigate laser treatment of a rare brain tumor, glioblastoma. 3.9 million euros has been made available for the research by Zorginstituut Nederland and ZonMw, under the auspices of the Subsidy Scheme for Promising Care.
Research on treatment for therapy-resistant obsessive-compulsive disorder1 April 2021
The Radboudumc is participating in a study, led by Amsterdam UMC, into a new, promising treatment for therapy-resistant obsessive-compulsive disorder. A sum of 2.8 million euros has been made available, with several other hospitals and mental healthcare institutions also participating.
RIMLS PhD retreat. Save the date(s)! 8 & 9 July or 14 & 15 Oct 20211 April 2021
How much are we all longing for an old-fashioned RIMLS PhD retreat full of science, workshops and fun! In normal years, the RIMLS 2-day PhD retreat is held in April. This year, however, it is not yet definitive. Final decision will follow in May.
Rare and complex urology: Clinical overview of ERN eUROGEN25 March 2021
Wout Feitz and colleagues, theme Reconstructive & Regenerative Medicine, Department of Urology, Division of Pediatric Urology (Radboudumc Amalia Children’s Hospital) publish an article in European Urology which well indicates the impact of ERN developments.
Immunomodulatory aged neutrophils are augmented in blood and skin of psoriasis patients24 March 2021
A new study by Radboudumc researchers show that Psoriatic patients have a unique neutrophil profile in circulation, and two distinct neutrophils subsets are present in psoriatic skin. The results are published in the Journal of Allergy and Clinical Immunology on the 19th of March.
High blood pressure variability a potential target for prevention of post-stroke dementia?24 March 2021
Radboudumc researchers investigated whether blood pressure levels and blood pressure variability influence the risk of post-stroke dementia, in an attempt to find a potential target for prevention of post-stroke dementia. Findings are published in Journal of Hypertension.
‘Mind the gap‘ between clinician-based and patient-relevant outcome measures.24 March 2021
Radboudumc researchers evaluated health-related quality of life, depressive symptoms, fatigue, and physical activity in patients with spinocerebellar ataxia. The results of this study, conducted at the Radboudumc Expert Center for Rare and Genetic Movement Disorders, is published in The Cerebellum.
Hidden genetic defects contain real risks for serious diseases Genome test for consanguineous couples makes sense19 March 2021
For the first time researchers from Hebrew University of Jerusalem, Radboudumc, Maastricht UMC+ and international colleagues have gained insight into the "hidden genetic defects" of the general European population.