Research news at Radboudumc.
Field research on malaria vaccine offers unexpected surprise23 May 2022
Field research on the effectiveness of a malaria vaccine, came up with unexpected results for an international group of researchers including Benjamin Mordmüller of Radboudumc. The vaccine evokes a broader response against malaria proteins than there are in the vaccine.
Five questions about monkeypox Answered by professor Chantal Bleeker-Rovers (update)20 May 2022
In the past weeks there has been a striking number of infections with so-called monkeypox in several Western countries. The first contamination has been spotted in the Netherlands today. What kind of disease is it and should we be worried about a major outbreak?
The future of laboratory animal research More attention to living conditions of laboratory animals16 May 2022
On May 9, a meeting took place at the Radboudumc as a result of the launch of the Dutch Transparency Agreement on Animal Testing. The Radboudumc is one of the twenty signatories and has thus committed itself to openly and transparently communicate its vision and policy with regard to animal testing.
Benjamin Wendt wins the Anna Reynvaan Science Prize 2022 prize for research into application of infection prevention measures in district nursing16 May 2022
On May 12, de Dag van de Verpleging, Benjamin Wendt won the Anna Reynvaan Science Prize 2022. This prize is awarded annually for the best scientific publication by a nurse from the previous year.
Only half of young female cancer patients get a chance to preserve their fertility Receiving fertility care in cancer improves quality of life and prevents regret13 May 2022
Of young female cancer patients, only half receives a referral to a gynecologist for a discussion about preserving her fertility, such as by freezing eggs. Researchers from the Radboudumc show that receiving this care leads to a better quality of life and less decision conflict and regret.
Arthritis drug use to limit antibiotics in blood cancer Drug Anakinra strengthens gut lining and inhibits inflammation12 May 2022
Researchers from the University of Adelaide and the Radboud University Medical Center have repurposed an arthritis drug to restrict the use of antibiotics in the treatment of side effects caused by blood cancer, including leukemia, lymphoma and myeloma.
Update on the use of Graphpad No campus license possible for Graphpad10 May 2022
Graphpad Prism is user-friendly software that is often used for analyzing and visualizing data. Unfortunately, the makers of Graphpad have decided that new versions are not available on virtual environments, such as our Werkplek/VMware.
Investigators must be BROK® certified at the start of the study10 May 2022
Since April 2022, the NFU tightened the BROK course policy. Researchers should now be BROK certified at the start of the research. The previous policy, which gave researchers 6 months after the start of the research to complete the BROK, is no longer valid.
Renee Salz wins prize for best presentation10 May 2022
Renee Salz won the award for best oral presentation during the Rolduc genetics retreat, organized by the Dutch and Belgian Societies of Human Genetics in Brugge. Her presentation was titled "Variant effect prediction based on long read transcriptomes".
Donal Hollywood award for research on radiation boost in prostate cancer Linda Kerkmeijer receives award during ESTRO 20226 May 2022
Linda Kerkmeijer will receive this year's Donal Hollywood award on behalf of the FLAME consortium during the ESTRO congress in Copenhagen on May 9. The award is given for the abstract on the added value of a radiation boost for localized prostate cancer in the FLAME study.
Combining targeted radionuclide therapy and immune checkpoint inhibition for cancer treatment4 May 2022
Simone Kleinendorst, Sandra Heskamp and colleagues, theme Rare cancers, published in Clinical Cancer Research about their research on combined radionuclide therapy and immunotherapy for cancer treatment.
Research sets standard for renal function of newborn babies Abnormal kidney function is now easier to detect28 April 2022
Researchers at Radboudumc have succeeded in establishing reference values for functioning of the kidneys of newborn babies. This allows for earlier detection of kidney injury and for improved dosing of drugs handled by the kidneys.
European grants for groundbreaking Radboudumc research Professors Roshan Cools and Peter Friedl receive ERC Advanced Grant26 April 2022
The European Research Council (ERC) is awarding grants to Roshan Cools and Peter Friedl, both professors at Radboudumc. While Cools will investigate how brains control behaviour in (stressful) situations, Friedl will work on developing a new cancer therapy.
When one kidney does the work of two ... Radboud university medical center studies the causes and consequences of solitary functioning kidney21 April 2022
The vast majority of people are born with two working kidneys, but sometimes only one healthy kidney develops. The other is missing, or is not properly constructed. Radboudumc studies how a solitary functioning kidney arises and what the consequences are for patients.
Centre for Drug Design and Discovery (CD3) is looking for druggable targets21 April 2022
As a UMC/University, we are experts in finding biomolecular processes that cause of diseases. These findings can result in the discovery of new targets for therapeutic purposes. To find and further develop the therapeutics that can manipulate these targets external partners are needed.
Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation published in Cellular and Molecular Life Sciences20 April 2022
Lisa Huis in ‘t Veld, Nataschja Ho and colleagues from the team of Gosse Adema published in Cellular and Molecular Life Sciences that Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation.
Camille Le Gall reports an efficient approach for delivery of poorly soluble tumor antigens to human cDC1s20 April 2022
Camille Le Gall published about an efficient targeting of NY-ESO-1 tumor antigen to human cDC1s by lymphotactin results in cross-presentation and antigen-specific T cell expansion in the Journal of Immunotherapy of Cancer.
Covid-related contract extension rounds for 2022, 2023 and 202419 April 2022
Research has been impacted heavily by the Covid-19 crisis and ongoing preventive measures. Especially researchers with a temporary appointment have been affected. A new application round for contract extension has been started, for researchers who are severly impacted by Covid-19.
Playing games to control emotions How cognitively demanding tasks can affect emotion regulation19 April 2022
Cognitive reappraisal can help us to control our emotions. It involves recognizing negative thought patterns, and gradually changing them to more effective patterns. A new study shows how the cognitive load of reappraisal, rather than the reappraisal itself, affects our emotional processing.
Radboudumc receives grant from Nationaal Groeifonds Investments in Biotech Booster, Oncode-PACT and PharmaNL19 April 2022
The Nationaal Groeifonds awards large grants to three consortia of which the Radboudumc is a member. Oncode-PACT, PharmaNL and Biotech Booster will receive amounts ranging from 80 to 325 million euros.
Researcher Marleen van Gelder cycles to Norway Action for research on preterm births14 April 2022
A special action by colleague Marleen van Gelder, assistant professor in the Department of Health Evidence. In exactly two months' time, she will be getting on her bicycle to draw attention - and especially money - to research into premature births.
Want to be sustainable and cool? Choose fans more and aircon less Keep cool and help the environment12 April 2022
A recent published study led by the University of Sydney, has found using indoor fans more often allows people to reduce their air conditioner use without changing how hot they feel, paving a way for reducing future energy use and greenhouse gas emissions. Coen Bongers, is one of the co-authors.
A "QR code" to read metabolism inside prostate cells: labeled extra-cellular citrate12 April 2022
In a recent publication in the Proceedings of the National Academy of Sciences USA, Frits van Heijster and his colleagues describe investigations to uncover which carbon sources and metabolic pathways are used by epithelial cells of the prostate to sustain high luminal citrate levels.
Mathias Prokop appointed department head of Radiology UMCG He also remains department head of Imaging Radboudumc11 April 2022
As of May 1, Mathias Prokop will become Department Head of Radiology at UMCG. He will fulfill this role in addition to his current position as Professor and Department Head of Imaging at the Radboudumc. Jurgen Fütterer will assume the daily management of the Radboudumc clinic.
Rosella Hermens appointed professor of Person-centered oncological integrated care7 April 2022
Rosella Hermens has been appointed Professor of Person-centered oncological integrated care at Radboud university medical center/Radboud University. She investigates how care for patients with cancer can become more person-centered and better organized, while the patient remains in control.
Neolithic made us taller and more intelligent, but more prone to heart disease How modern European populations have evolved over the past 50,000 years6 April 2022
After the Neolithic, European populations showed an increase in height and intelligence, reduced skin pigmentation and increased risk of cardiovascular disease due to genetic changes that lowered concentrations of 'good' HDL cholesterol.
Aiosyn and Radboudumc are the first in the Netherlands to implement AI in the clinical pathology workflow Digital pathology slides will be screened with a quality control algorithm4 April 2022
Aiosyn, a company that develops AI-powered computational pathology analysis for clinical diagnostics, and the department of pathology of Radboudumc, will collaborate to implement an algorithm for quality control of digitized histopathology tissue slides.
Joyce Aarts and colleagues published in Scientific Reports about the role of TGF-β1 in (experimental) arthritis30 March 2022
Joyce Aarts, theme Inflammatory diseases, and her colleagues published in Scientific Reports, that local inhibition of TGF-β1 signaling improves Th17/Treg balance but not joint pathology during experimental arthritis.
Five million euro’s for joint research on rare movement disorders29 March 2022
A Dutch consortium will receive almost 5 million euro’s from NWO to jointly start an ambitious project, called CureQ, on various rare and genetic brain disorders that lead to abnormal movements. Bart van de Warrenburg was one of the main applicants of this ‘Nationale Wetenschaps Agenda (NWA)’ grant.
Donders Citylab launched at the muZIEUm in Nijmegen city centre29 March 2022
The Donders Institute and the muZIEum have launched the CityLab in the Nijmegen city centre. The Citylab aims to bring science and the general public together by combining research, entertainment and education, a schoolbook example of citizen science.
Scientists find that the impact of social media on wellbeing varies across adolescence29 March 2022
Girls and boys might be more vulnerable to the negative effects of social media use at different times during their adolescence, say an international team of scientists in a study published today in Nature Communications.