Tjitske Kleefstra appointed endowed professor of Clinical genetics and psychopathology of rare syndromes17 September 2020
Tjitske Kleefstra has been appointed endowed professor of Clinical genetics and psychopathology of rare syndromes at the department of Neurodevelopmental disorders, with effect from 1 September.
Annette Schenck appointed professor of Translational Genetics17 September 2020
Annette Schenck has been appointed professor of Translational Genetics at the department of Neurodevelopmental disorders, with effect from 1 August. The chair will bring together fundamental and translational research in the field of brain developmental disorders.
Transfer of new anti-hepatitis C drugs across the human placenta9 September 2020
In a recent publication in American Journal of Obstetrics and Gynecology, researchers from the Departments of Pharmacology and Toxicology, Pharmacy, Obstetrics and Gynecology, Gastroenterology and Hepatology, investigated the placental passage of two such drugs for the first time.
Nanda Rommelse appointed endowed professor of Neurodevelopmental disorders8 September 2020
Nanda Rommelse has been appointed professor of Neurodevelopmental disorders with effect from 1 September. The chair will function as a bridge between the Psychiatry Department of the Radboudumc with Karakter Child and Adolescent Psychiatry.
Does the COVID-19 cytokine storm exist? Research may have an impact on the chances of success of a specific treatment4 September 2020
Following the measurement of several important cytokines in patients with COVID-19 and various other severe diseases, researchers at Radboud university medical center now show that COVID-19 is not characterized by a cytokine storm.
Effects of pathogenic fungus screened internationally new fungus Candida auris first observed in 20091 September 2020
Mariolina Bruno, Simone Kersten and Mihai Netea, and colleagues have discovered that the human immune system recognizes the fungus well. Their study has been able to pin-point the fungus' Achilles heel for new, effective drugs. This has recently been published in Nature Microbiology.
Tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture26 August 2020
Carl Figdor and colleagues showed in Nature Communications that the tumour microenvironment (TME) forms a major obstacle in effective cancer treatment and for clinical success of immunotherapy.
Interference transitions in case of invasion of breast cancer determined by cell-cell adhesion and 3D matrix confinement25 August 2020
Peter Friedl and colleagues, theme Cancer development and immune defence, published in Nature Cell Biology (NCB) the mechanisms of jamming and unjamming transitions of mammary carcinoma invasion along tossue microtracks.
Universal Tumor DNA BRCA1/2 Testing of Ovarian Cancer Prescreening PARPi Treatment and Genetic Predisposition20 August 2020
Nicoline Hoogerbrugge, Iris Nagtegaal and Marjolijn Lightenberg published that Universal Tumor BRCA1/2 testing in all newly diagnosed ovarian cancer patients is feasible and effective.
Severe oxygen deficiency corona patient seems treatable ZonMw funds follow-up research into drug effectiveness18 August 2020
Frank van de Veerdonk, Mihai Netea and Roger Brüggemann wrote in JAMA Network Open, that Corona patients with severe oxygen deficiency react positively to treatment with icatibant.
Collective invasion induced by autocrine purinergic loop through connexin-43 hemichannels13 August 2020
Peter Friedl, Paul Span and Antoine Khalil show in Journal of Cell Biology that breastcancer cells release purines into the extracellular space via connexin-43 hemichannels to control collective invasion.
TP53 allelic state is critical for diagnostic and prognostic precision in blood cancer12 August 2020
An international study, in which Joop Jansen participated, shows that a double mutaton in TP53 gene deteriotes the prognosis of a rare form of blood cancer. If there is only one mutation or no mutation, then the prognosis is better.
650,000 Euro funding for research into the phasing out of medication for leukaemia patients30 July 2020
With a 650,000 euro funding from ZonMw, researchers from the Haematology and Pharmacy departments can develop a medication phasing out strategy for patients with chronic myeloid leukaemia. This strategy will be tested in practice.
Increased role of patients after bowel cancer treatment30 July 2020
Approximately 14,000 patients get colorectal cancer every year. Almost all patients are operated on and monitored afterwards (follow-up). In 2019 Radboudumc started a new approach to follow-up research after the treatment of stage II/III colorectal cancer.
Hypatia fellowship Call is open30 July 2020
The Hypatia fellowship round with the deadline 31 May has been canceled. Therefore, the next available deadline will be 27 September 2020. Radboudumc researchers are invited to scout young potentials to fill the strategic gaps within the research themes imbedded in RIHS and RIMLS.
Mihai Netea and colleagues published two papers back-to-back in The Journal of Clinical Investigation.29 July 2020
These back-to-back articles investigated the effect of BCG vaccination on trained immunity. The first article shows that BCG vaccination inhibits systemic inflammation, depending on gender. The second article demonstrates that the circadian rhythm influences the induction of trained immunity.
Improved method for detecting lung cancer24 July 2020
Radboudumc researchers are the only ones in the Netherlands using a new method to make better lung cancer diagnoses earlier stage. Erik van der Heijden and Roel Verhoeven shows that the use of flexible imaging equipment via the natural respiratory tract contributes to a more accurate diagnosis.
Optimizing workup in head and neck cancer (HNC)23 July 2020
In the journal Cancer RIHS researcher Henrieke Schutte described the outcomes after the implementation of a fast-track multidisciplinary integrated HNC care program: time-to-treatment was significantly reduced and survival and patient satisfaction increased significantly without increasing costs.
Less registration leads to more time for the patient16 July 2020
On average, care providers spend more than 52 minutes of their working day on quality registrations. Only 36% of these registrations can be used to improve care and that the registration burden weighs on the motivation of care providers.
ATRO Medical, Radboudumc and Samaplast develop new meniscus prosthesis Consortium receives EUROSTARS grant for innovative project16 July 2020
An international consortium led by ATRO Medical, a spin-off of Radboudumc and DSM, will receive € 800,000 European funding for an innovation aimed at patients with knee osteoarthritis. These patients often suffer from cartilage wear due to a meniscus that no longer works properly.
First podcast 'AI for Life' about Artificial Intelligence in Nijmegen Podcast on medical image processing with Bram van Ginneken, Ritse Mann and Eva van Rikxoort16 July 2020
The first podcast on Artificial Intelligence (AI) in Nijmegen was released today. In this podcast on spotify and anchor Bram van Ginneken, Ritse Mann and Eva van Rikxoort talk about AI and medical image processing. The next podcast is about smart chatbots.
Cardiac function in relation to myocardial injury in hospitalised patients with COVID-1916 July 2020
In Netherlands Heart Journal RIHS researcher Frederik van den Heuvel described that in hospitalized COVID-19 patients, COVID-19 predominantly affects the respiratory system, while cardiac dysfunction occurs less often.
Rebecca Halbach receives idea generator grant to fight mosquito transmitted viruses8 July 2020
Rebecca Halbach and Pascal Miesen have investigated in a collaborative project whether the treatment of mosquitoes with antiviral drugs can prevent the transmission of mosquito-transmitted viral diseases.
Invasive fungal infections in influenza and COVID-198 July 2020
The Aspergillus fungus is found in the lungs of many COVID patients. A parallel occurs with influenza patients, who often develop a serious fungal infection. Although such a serious fungal infection seems to occur less frequently in COVID-patients, alertness remains necessary,
Online conference offers advantages for scientists2 July 2020
Flying around the world for every congress is outdated. Scientists can now choose for a more environmentally conscious option. Published in 'De Volkskrant', Radboudumc researchers Teun Bousema, Estel Collado and Julie Verhoef argue that the online congress can offer serious advantages.
Experts on metabolic diseases still an unknown major problem...1 July 2020
Six Dutch UMCs and a patient association contribute to treating and solving this major, often unknown, problem. Timely detection of metabolic diseases is vital. Therefore, Radboudumc is also part of the consortium “United for Metabolic Diseases”.
Stefan Listl member Lancet Commission on Oral Health29 June 2020
In recognition of the global public health importance, woeful neglect of oral diseases, and the need for a broader understanding and commitment to global oral health within medicine and global health agendas, The Lancet recently established a Commission on Oral Health.
Trained immunity: a tool for reducing susceptibility to and the severity of SARS-CoV-2 infection29 June 2020
In a review in Cell Mihai Netea, Frank van de Veerdonk, Reinout van Crevel and Jorge Dominguez Andres propose that induction of trained immunity by whole-microorganism vaccines may represent an important tool for reducing susceptibility to and severity of SARS-CoV-2.
Master Prizes 2018-2019 awarded for best internship reports24 June 2020
Which students have made the best reports of their scientific internship? On 18 June the Radboudumc Master Prizes were awarded, an annual tradition to reward 'remarkably good scientific work by students'. This year's presentation was virtual, given the corona conditions.