Biochemical recurrence occurs in >20% of treated prostate cancer patients, mainly due to metastatic disease (>80%). In the multicenter clinical study ADOPT, 280 men with oligo-recurrent prostate cancer from 10 participating hospitals in the Netherlands are randomized to receive standard metastasis-targeted radiotherapy or metastasis-targeted radiotherapy in combination with 6 months of ADT. Biomaterial from eligible ADOPT patients will be used to establish the ADOPT biobank. Patients eligible for the ADOPT study will be asked to consent to blood collection prior to treatment and during 6 and 12 month follow-up. The ADOPT biobank plans to use new technology to identify and validate circulating tumor DNA (ctDNA) and extracellular vesicle (EV) biomarker. These will then be used as predictive and prognostic tools to improve the timing of clinical treatment and to more accurately monitor treatment response.
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