About Experimental internal medicine
We investigate the regulation of innate immune responses in health and disease, and based on that we design and test new approaches of immunotherapy in infections and immune-mediated diseases.
Research programs
Programs that are connected to this research group.
Publications
See the publication list of the research group leader on Web of Science.
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- Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial. - Giamarellos-Bourboulis, E. J., Kotsaki, A., Kotsamidi, I., Efthymiou, A., Koutsoukou, V., …, Ntaganou, M., Gkeka, E., Bauer, M., Mouloudi, E. & Netea, M. G.; ImmunoSep Study Group – 2026 (JAMA)
- Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory. - Ziogas, A., Novakovic, B., Ventriglia, L., Galang, N., Tran, K. A., Li, W., …, Martens, J. H. A., Li, Y., Divangahi, M., Joosten, L. A. B., Mhlanga M. M., & Netea, M. G. – 2025 (Cell)
- Transmission of trained immunity and heterologous resistance to infections across generations. - Katzmarski, N., Domínguez-Andrés, J., Cirovic, B., Renieris, G., Ciarlo, E., Le Roy, …, Walter, J., Schultze, J. L., Roger, T., Giamarellos-Bourboulis, E. J., Schlitzer, A., & Netea, M. G.- 2021 (Nature immunology)
- Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly - Giamarellos-Bourboulis, E. J., Tsilika, M., Moorlag, S., Antonakos, N., Kotsaki, A., Domínguez-Andrés, J., …, Koenen, H., van Crevel, R., Droggiti, D. I., Renieris, G., Papadopoulos, A., & Netea, M. G. - 2020 (Cell)
- Metabolic Induction of Trained Immunity through the Mevalonate Pathway. - Bekkering, S., Arts, R. J. W., Novakovic, B., Kourtzelis, I., van der Heijden, C. D. C. C., Li, Y., …, Chavakis, T., Joosten, L. A. B., van der Meer, J. W. M., Stunnenberg, H., Riksen, N. P., & Netea, M. G. - 2018 (Cell)
- Host and Environmental Factors Influencing Individual Human Cytokine Responses - Ter Horst, R., Jaeger, M., Smeekens, S. P., Oosting, M., Swertz, M. A., Li, Y., …, Dinarello C. A., Pavelka, N., Wijmenga, C., Notebaart, N.A., Joosten, L. A. B. & Netea, M. G. - 2016 (Cell)
- Trained immunity: A program of innate immune memory in health and disease. - Netea, M. G., Joosten, L. A., Latz, E., Mills, K. H., Natoli, G., Stunnenberg, H. G., O'Neill, L. A., & Xavier, R. J. - 2016 (Science)
- mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity . - Cheng, S. C., Quintin, J., Cramer, R. A., Shepardson, K. M., Saeed, S., Kumar, V., … Ng, A., Joosten, L. A., Wijmenga, C., Stunnenberg, H. G., Xavier, R. J., & Netea, M. G. - 2014 (Science)
- STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. - van de Veerdonk, F. L., Plantinga, T. S., Hoischen, A., Smeekens, S. P., Joosten, L. A., Gilissen, C., Arts, P., ... , Smits-van der Graaf, C. A., Kullberg, B. J., van der Meer, J. W., Lilic, D., Veltman, J. A., & Netea, M. G. - 2011 (The New England Journal of Medicine)
Our members
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Ioannis Morianos postdoc Interne Geneeskunde
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Leonie Helder staff researcher
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Vasiliki Matzaraki biostatisticus
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Jeroen Deckers wetenschappelijk onderzoeker