Human challenge models

Research Research programs Human challenge models

Our mission

We aim to strengthen the capacity, broaden the scope and increase the impact of Radboudumc's research on health in the field of in vivo human models.

Goals

See some of the most important goals for this research program.

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Goals

To develop new challenge models (e.g. P. vivax, B. pertussis), improve methodology (study designs, simulation and mathematical modeling, biomarker development) and validate challenge models with real world data.
To use existing synergies to identify and close gaps in human capacity and infrastructure to further increase international visibility and to apply for external funding.
To establish and assess the program's governance models.

Research groups contributing to this research program

Experimental internal medicine

Mihai Netea's research group investigates the regulation of innate immune responses in health and disease, and based on that it designs and tests new approaches of immunotherapy in infections and immune-mediated diseases.

Experimental medical parasitology

Benjamin Mordmüller's research group discusses, develops and uses human challenge models to investigate infection, pathophysiology and transmission of infectious agents with the aim to improve medical interventions.

Infection and immunity

Marien de Jonge's research group conducts research on mucosal immunity in the respiratory tract and aims to unravel host-pathogen interactions to improve diagnosis and protection against airway infections.

Spokesperson

prof. dr. Benjamin Mordmüller

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