About this research groupOur bacterial research is primarily focused on the diagnostics of bacterial infections and antibiotic resistance. Antibiotic resistance has emerged in the last decade. This is mainly caused by global misuse and overuse of antibiotics and by transmission of resistance genes between bacteria.
Our bacteriology research group aims to optimize and advance the diagnosis of bacterial infections and antibiotic resistance. As a result, an antibiotic treatment can be stopped quickly or can be correctly directed to the bacterium responsible for the infection. This will ultimately lead to better treatment of the patient, reduction of broad-spectrum antibiotic use and reduction of antibiotic resistance.
Whole genome sequencing
By using new technologies, antibiotic resistance in patients can be detected more quickly and efficiently. In recent years, whole genome sequencing has taken a prominent role in our research on bacterial resistance mechanisms. By studying the complete genome of a bacterium, we are able to discover new resistance mechanisms and are able to investigate outbreaks of resistant bacteria. It is possible to perform bacterial typing and discover transmission routes of resistant bacteria in any setting. Our goal is to implement this technique as a routine diagnostic tool in clinical practice.
Tailor-made antibiotic prophylaxis
An important factor contributing to the overuse and misuse of antibiotics in hospitals is the antibiotic prophylaxis used in surgery. Antibiotic prophylaxis is frequently continued for days after surgery and often does not adequately cover the unique bacterial flora of the patient. Due to the emergence of antibiotic resistance, standard prophylaxis regimens increasingly fail to prevent infections. In collaboration with the urology department, we will roll out a directed prophylaxis strategy based on resistance data of individual patients, thereby aiming to reduce infectious complications after surgery. This is a unique strategy that is not yet been applied in the Netherlands.