About this research group
Our research group focuses on the application of latest genomic technologies to understand human disease. A particular emphasis is put in the understanding of genetic defects that explain immune diseases, in particular primary immunodeficiencies (PIDs).
The immuno-genomics group combines expertise in genomics and immunology. This research group is affiliated with the Department of Human Genetics and the Department of the Internal Medicine of the RadboudUMC and also affiliated with the RIMLS.
AlumniFormer group members
- Dr Peer Arts, former PhD student, now postdoc in Adelaide
- Dr Rocío Acuna Hidalgo, former PhD student, now postdoc in Berlin
- Dr Wybrich Cnossen former PhD student (co-supervised with Prof Dr Joost Drenth and Prof Dr Joris A Veltman)
- Dr Clara Serra Juhé; former PhD student and visiting scientist, current position: University Popeu Fabra, Barcelona, Spain
- Dr Gael Nicolas (visiting scientist 2016/2017); current affiliation: Department of Genetics and CNR-MAJ Normandie Univ, UNIROUEN, Rouen University Hospital, Normandy Center for Genomic and Personalized Medicine, France
- Hilal Sengül (master student 2016/2017)
- Elanur Yilmaz (visiting scientist 2016)
- Nehir Kurtas (master student 2015/2016)
- Tan Bo (visiting scientist 2014); State Key Laboratory of Medical Genetics, Central South University
- Dr Kerstin Ludwig (visiting scientist 2015); University Bonn, Institute of Human Genetics, Department of Genomics
- Dr Benjamin Rodriguez-Santiagio (visiting scientist 2011/2012); QGenomics
See most recent grants.
- X-omics: The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.
- RIMLS Radboudumc junior researcher (PhD) position on “Functional genomics of primary immunodeficiencies – towards personalized medicine in PIDs” Co-supervised with Mihai Netea and Frank van de Veerdonk [Radboudumc junior researcher (PhD) position]
- SOLVE-RD: EU H2020 grant to identify causes of rare disease and develop diagnostic tests of the future: read press release in Dutch or English
- UNPIN - Unraveling pimary immunodeficiencies by Sigrid Juselius (personal grant for Tuomo Mantere)
- RIMLS Radboudumc junior researcher (PhD) position on “Solving the Unsolved – Integrated DNA and RNA - Analysis to Unravel the Causes of Primary Immunodeficiencies”
See most recent publications.
- Exome sequencing in routine diagnostics: a generic test for 254 patients with primary immunodeficiencies. Arts et al. Genome Medicine. 2019 11:38. See publication
- Editorial: NGS: Gestern, heute und morgen [in German]. Bolz and Hoischen. Medizinische Genetik in press. See publication
- Long-Read Sequencing Emerging in Medical Genetics. Mantere, Kersten, Hoischen Front Genet. 2019 May 7;10:426. See publication
- Somatic variants in autosomal dominant genes are a rare cause of sporadic Alzheimer's disease. Nicolas et al. Alzheimers Dement. 2018 Dec;14(12):1632-1639. See publication
- A genotype-first approach identifies an intellectual disability-overweight syndrome caused by PHIP haploinsufficiency. Jansen, Hoischen et al. Eur J Hum Genet. 2018 Jan; 26(1):54-63. See publication
- Ultra-sensitive Sequencing Identifies High Prevalence of Clonal Hematopoiesis-Associated Mutations throughout Adult Life. Acuna-Hidalgo et al. Am J Hum Genet. 2017 Jul 6;101(1):50-64. See publication
- Quantification of differential gene expression by multiplexed targeted resequencing of cDNA. Arts et al. Nat Commun. 2017 May 5;8:15190. See publication
See most recent press releases.
In the media
- KAS Paper: Medizinische Genomsequenzierung: Bedeutung für Krankenversorgung und Genomforschung
- GlobeNewswire News: Bionano Genomics’ Saphyr® System is Adopted by GeneDx for the Clinical Detection of Genetic Variants in Muscular Dystrophies, Developmental and Reproductive Disorders
- Radboudumc News: Alexander Hoischen appointed as associate professor
- Radboudumc Grants overview: RIMLS highlights 2018
- GlobeNewswire News: Results Presented at ESHG 2019 Showcase the Advantages of Saphyr over Traditional Cytogenetics Methods for the Detection of Structural Variants in Patients with Genetic Disease and Cancer
- GlobeNewswire News: Global Adoption of Bionano Genomics’ Saphyr® System Accelerating for Clinical Genomics Applications
- Genomeweb News: Radboudumc, NimaGen Partner to Develop Targeted Sequencing Kits
- Genomweb Interview: Long-Read Sequencing May Help Resolve Complex Structural Variants to Diagnose Rare Diseases
- Nature.com Webcast: Sequencing Structural Variants for Disease Gene Discovery and Population Genetics
- Genomeweb Interview: Team Modifies Molecular Inversion Probes to Capture Kilobase-Sized DNA for Cloning, Sequencing
- Genomeweb Expert-opinion on new technology
- Science Feature: Killer clones
- The Scientist News: Mosaic Mutations May Not Be Rare
- Radboudumc News: Timing of mutation determines the outcome