Research Research groups Pharmacology and toxicology

About this research group

This research group develops computational models that predict fetal-maternal drug exposure in pregnancy and brain penetration of drugs in adults and children.

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About this research group

Our main achievements and examples of research: Advances from our transporter research have led to an increased understanding of renal and hepatic drug excretion and toxicity, drug transfer across the placenta, intestine and blood brain barrier, and the role of efflux transporters in signal transduction and multidrug resistance in infectious diseases.

By applying a systems pharmacology approach, computational models have been developed to predict fetal-maternal drug exposure in pregnancy and brain penetration of drugs in adults and children. Novel mechanisms of drug-induced mitochondrial toxicity were identified in muscle and kidney. The above efforts have contributed significantly to assuring drug safety without animal testing.


Research group leader

prof. dr. Frans Russel

+31 (0)24 361 36 91
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Aims

Our group has several aims.

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Aims

Research interests include the role of transporters in drug efficacy and safety, pharmacokinetic modelling and systems pharmacology of therapeutic and off-target bioenergetic drug effects. An important goal is to translate molecular-based knowledge of drug exposure and action to the clinical setting, to assist in the development of more effective and safer personalized drug therapies.